DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and ush2a

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	502	Identity:	106/502 - (21%)
Similarity:	158/502 - (31%)	Gaps:	170/502 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GGGGGGVGTAQGKHPSGSKTVATGVVPNFGGAAGNGAGGGGPV---AGSGTGSTVVGSNGVIVAG 96
            ||...||     .||:.:|   ..::..|||...:.....|||   |...:.:..|..:|.:.|.
Zfish  1861 GGVPPGV-----THPALNK---HSLLHGFGGCIRDVRLARGPVVSLAAVSSSAVRVNLDGCLSAD 1917

  Fly    97 GGANVPTSNLNIVVE------------EPEFTEYIENV--------------------TVPAGRN 129
            ...|. ..|.:|:|.            :| ||||:..|                    |||....
Zfish  1918 TSVNC-RGNDSILVYTGRDRSAEDLTLQP-FTEYLYRVMASGEGGWIGGPWQRGRSRETVPQSVL 1980

  Fly   130 VKLGCSVKNLGSYKVAWMHFEQSAIL--TVHNHVITRNPR-------ISVTHDKHDRHRTWYLHI 185
            ........|..|.:|:|   |:.|.:  .:..:|:....|       ||.|. .|.:|.|..|
Zfish  1981 PPSRVGSVNGSSVEVSW---EEPAEVRGVIEKYVLKAYSRDRPSSSPISATF-PHSQHLTGTL-- 2039

  Fly   186 NNVHEEDRGRYMCQINTVTAKTQFGY--------LNV------VVPPNIDDSLSSSDVIVREGAN 236
                 .....:.....|:||.||.|.        .|.      .|||....|..:
Zfish  2040 -----SGLAPFSSYSITLTACTQAGCSESPFATGFNTPQEAPEEVPPPAAVSYPN---------- 2089

  Fly   237 ISLRCRASGSPRP---IIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYL------- 291
             ||....:..|:|   ||::       |....|.::......:..||     |:|.:.
Zfish  2090 -SLSVHWNHPPKPNGIIIQY-------ILYKNNTVLYRGNSTSFNIT-----DVGVFTPHKLLLS 2141

  Fly   292 ------CIASNGV-------PPTVSKRIKVSVDFPPMLLI-----PHQLVGAPEGFNVTIECFTE 338
                  |..|..|       |||..:        ||:|.:     .|....||...|..:|.:|
Zfish  2142 ACTEAGCTNSTQVTLFTGQLPPTYVE--------PPILTVLDARSIHIQWAAPVEVNGLLEFYT- 2197

  Fly   339 AHPTSLNYWTRGEGP-IIHDSHKYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGET 402
                 |:.|..||.| |:::|.             :.....|:.|:..|...:::..|....|.|
Zfish  2198 -----LHQWALGEEPLIVYNSS-------------ELFQDYTVRNLVPGSTYLFQIAACTGGGCT 2244

  Fly   403 ---DGIIRLYVSYPPTTASSGIYSTDTH-----W----GENGINNNY 437
               ....|...|.|....:..|.|...|     |    ..||:.::|
Zfish  2245 LSDPSTARTEESSPEEVPAPNILSLSPHSLHLSWTPPRKPNGVISSY 2291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	26/138 (19%)
		Ig	130..200	CDD:143165	15/78 (19%)
		I-set	226..310	CDD:254352	18/106 (17%)
		IGc2	233..298	CDD:197706	14/80 (18%)
		Ig	313..410	CDD:299845	23/105 (22%)
		IG_like	325..410	CDD:214653	19/88 (22%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058	10/36 (28%)
		FN3	1981..2071	CDD:238020	21/100 (21%)
		FN3	2163..2253	CDD:238020	24/116 (21%)
		FN3	2258..2341	CDD:238020	8/34 (24%)
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900