DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and SDK2

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	503	Identity:	109/503 - (21%)
Similarity:	187/503 - (37%)	Gaps:	139/503 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LPPSWH----LIGALLVLAATAGDSTNKIILPQILNGGGGGGGVGTAQGKHPSGSKTVATGVVPN 62
            :|||..    |...|::|:..|.|:....:  |.:|...|..  .|:|         ..|..|.|
Human   154 IPPSSRIAITLENTLVILSTVAPDAGRYYV--QAVNDKNGDN--KTSQ---------PITLTVEN 205

  Fly    63 FGGAAGNGAGGGGPVAGS-----GTGSTVVGS-----------------------NGVIVAGG-- 97
            .||.|       .|:|.:     ...|.|.|:                       :||:::||
Human   206 VGGPA-------DPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS 263

  Fly    98 --------------------------GANVPT----SNLNIVVEEPEFTEYIE-NVTVPAGRNVK 131
                                      .::||:    :.|: |:|.|:|.:..| ::|....:.|.
Human   264 DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS-VLEPPQFVKEPERHITAEMEKVVD 327

  Fly   132 LGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDRHRTWYLHINNVHEEDRGRY 196
            :.|..|.:....:.|  ::.:|::.|..  :||      ...::|..    |.|:.:..:|.|.:
Human   328 IPCQAKGVPPPSITW--YKDAAVVEVEK--LTR------FRQRNDGG----LQISGLVPDDTGMF 378

  Fly   197 MCQINTVTAKTQFG-YLNVV-VPPNIDDSLSSSDVIVREGANISLRCRASGSPRPIIKWKRDDNS 259
            .|.......:.|.. ||.|. :.|||......|.||  :|.::.|.|..||:|||.|.|::.:
Human   379 QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI--DGMSVVLACETSGAPRPAITWQKGE-- 439

  Fly   260 RIAINKNHIVNEW---EGDTLEITRISRLDMGAYLCIASN--GVPPTVSKRI---KVSVDFPPML 316
            ||..:.:..:..:   |..:|.|:.....|.|.|.|:|:|  ||....:..:   :..:..||
Human   440 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPP-- 502

  Fly   317 LIPHQLVGAPEGFNVTIECFTEAHP-TSLNY-WTRGEGPIIHDSH-KYKVEATVGLPAYKTHMKL 378
                |.....:|...::.|.....| .::.| |.:....:..:|| :.:::....|     |:..
Human   503 ----QDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSL-----HISQ 558

  Fly   379 TIINVSSGDDGIYKCVAKNPRGETDGIIRLYV-------SYPPTTASS 419
            |    .|||.|.|.|...:..|.......|.|       .:|..|.|:
Human   559 T----WSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLST 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	20/98 (20%)
		Ig	130..200	CDD:143165	14/69 (20%)
		I-set	226..310	CDD:254352	26/91 (29%)
		IGc2	233..298	CDD:197706	21/69 (30%)
		Ig	313..410	CDD:299845	21/99 (21%)
		IG_like	325..410	CDD:214653	18/87 (21%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	14/61 (23%)
		Ig	132..210	CDD:299845	18/68 (26%)
		IG_like	222..304	CDD:214653	10/82 (12%)
		IGc2	233..286	CDD:197706	4/52 (8%)
		I-set	308..397	CDD:254352	21/102 (21%)
		Ig	326..394	CDD:143165	15/81 (19%)
		I-set	402..492	CDD:254352	29/93 (31%)
		Ig	416..492	CDD:299845	23/77 (30%)
		Ig	502..586	CDD:299845	20/98 (20%)
		IG_like	502..586	CDD:214653	20/98 (20%)
		FN3	590..681	CDD:238020	3/13 (23%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810