DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-zeta and klg

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	108/409 - (26%)
Similarity:	178/409 - (43%)	Gaps:	42/409 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VVPNFGGAAGNGAGGGG---PVAGSGTGSTVVGSNGVIVAGGGANVPTSNLNIVVEEPEFTEYIE 120
            :|.:.|......||.||   ..|.|..||.....:.|..:...|:..|:.|      |.|.....
  Fly    50 IVISLGWLLHAHAGSGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATL------PRFLSRGH 108

  Fly   121 NVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDRHRTWYLHI 185
            ......|..:.|.|.|:|||::.:.|.  ..:.:||..|.::||:.|:.:...       :.|.|
  Fly   109 TYRAVVGDTLVLPCQVENLGNFVLLWR--RGTNVLTASNIMVTRDERVRLIDG-------YNLEI 164

  Fly   186 NNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRCRASGSPRPI 250
            :::..:|.|.|:|||:....:.|...:.::|||::....:|..:..|:|..|:|.|:.||:|.|.
  Fly   165 SDLEPQDAGDYVCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPS 229

  Fly   251 IKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGVPPTVSKRIKVSVDFPPM 315
            |.|.:...:    ||: .....:|..|.:.::.|...|.|.|.|.|||...|:..:::.|.:||.
  Fly   230 IYWTKKSGA----NKS-TARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPD 289

  Fly   316 LLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGPIIHDSHKYKVEATVGLPAYKTHMKLTI 380
            :.:....:.:.|||...:.|...|.|.:...|.:...||  .|...::.||    ....|| |||
  Fly   290 IQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPI--QSTDRRIMAT----RANRHM-LTI 347

  Fly   381 INVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPPTTASSGIYSTDTHWGENGINNNY-----AYG 440
            .::...|.|.|.|||.|..|.:    |.|:.......::..||  ..||.:..:.|.     :|.
  Fly   348 RHIQQEDFGNYSCVADNSLGRS----RKYMELSGRPGAAEFYS--PKWGRSPDSYNLTWKIDSYP 406

  Fly   441 GPDSTRSIYAQ-DKNTRYQ 458
            ..:..|.:|.: ..|..||
  Fly   407 PLEEVRLLYRRVQMNETYQ 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	23/95 (24%)
		Ig	130..200	CDD:143165	19/69 (28%)
		I-set	226..310	CDD:254352	25/83 (30%)
		IGc2	233..298	CDD:197706	20/64 (31%)
		Ig	313..410	CDD:299845	28/96 (29%)
		IG_like	325..410	CDD:214653	26/84 (31%)
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	16/66 (24%)
		IG_like	109..195	CDD:214653	23/94 (24%)
		Ig	118..191	CDD:143165	22/81 (27%)
		IG_like	205..274	CDD:214653	24/73 (33%)
		IGc2	213..273	CDD:197706	21/64 (33%)
		IGc2	301..367	CDD:197706	24/72 (33%)
		FN3	392..486	CDD:238020	7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442838
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	4	3.740