DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and DIP-theta

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	165/426 - (38%)
Similarity:	245/426 - (57%)	Gaps:	48/426 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LNIVVEE--PEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRI 168
            :|.:.|:  |:|.|.::|||||..|...|.|.|.||.:||:||:..:...|||:.|||||:|.|:
  Fly   121 VNAIPEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRM 185

  Fly   169 SVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVRE 233
            |:||.:   .|.|.|.|.:|.|.|:|.|||||||...|:|.|||:|||||:|.|..:|:|:::||
  Fly   186 SITHAE---KRAWILRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPDILDYPTSTDMVIRE 247

  Fly   234 GANISLRCRASGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGV 298
            |:|::|:|.|:|||.|.|.|:|:....|.:........:.|..|.|.:::||:|||||||||||:
  Fly   248 GSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGI 312

  Fly   299 PPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGPIIHDSHKYKV 363
            |||||||:.:.|.||||:.|.:|||||....|:|:||.:||:|.|:|||.:.: .||....::..
  Fly   313 PPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKND-TIIVPGERFVP 376

  Fly   364 EATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDGIIRLY--------VSYPPTTASSG 420
            |....  .||..|:|||..|...|.|.|:|||||..|:|||.|:||        .:..||.:.:.
  Fly   377 ETFES--GYKITMRLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINT 439

  Fly   421 I------YSTDTHWG--ENGINNNYAYGGPDSTRSIYAQDKNTRYQ-------------SNLNEI 464
            :      |:.:..:|  :|...|.|.:...:|       .:||:.|             |.||.:
  Fly   440 VPVVLVKYNKEQRYGSSQNSNTNPYNFNPGNS-------QQNTKLQRGKSNSKGSDQSPSGLNNV 497

  Fly   465 GLSEQKSFLDKTQNPLLANGNANEADAESNGARGHN 500
            .:....|..:...:    :.:::.:.:.|:..|.|:
  Fly   498 FVGATSSLWNSQDH----HSSSSSSSSASSRGRDHH 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	49/95 (52%)
		Ig	130..200	CDD:143165	33/69 (48%)
		I-set	226..310	CDD:254352	40/83 (48%)
		IGc2	233..298	CDD:197706	29/64 (45%)
		Ig	313..410	CDD:299845	45/104 (43%)
		IG_like	325..410	CDD:214653	37/92 (40%)
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	49/95 (52%)
		IG_like	137..230	CDD:214653	49/95 (52%)
		IG_like	240..324	CDD:214653	40/83 (48%)
		IGc2	247..310	CDD:197706	27/62 (44%)
		Ig	327..419	CDD:299845	43/94 (46%)
		IG_like	343..420	CDD:214653	34/79 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11903
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102333at6960
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	9	8.970