DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and DIP-kappa

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	181/416 - (43%)
Similarity:	250/416 - (60%)	Gaps:	34/416 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDR 177
            |.|.|.|.||||..||:..:.|.|:||..|||||:..:...||::|::||::|.|||:|::.
  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYND--- 135

  Fly   178 HRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRCR 242
            ||:|||||..|.|.|||.||||:||...:::.|||.|||||.|.:.|:|:|::||||.||||.|:
  Fly   136 HRSWYLHIKEVEETDRGWYMCQVNTDPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCK 200

  Fly   243 ASGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGVPPTVSKRIK 307
            |.|.|.|.:.|:|:|...:.|...| ||..:|:.|.||::|||.|.||||:|||||||::|||:.
  Fly   201 ARGYPEPYVMWRREDGEEMLIGGEH-VNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVH 264

  Fly   308 VSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGP-IIHDS----HKYKVEATV 367
            :.|.|||||.||:||.||..|.:|.:||.|||:|.|:||||...|. ||.|:    .||:..:||
  Fly   265 LRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTSTV 329

  Fly   368 GLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPPTTASSGIYSTDTHWGENG 432
            .  .|..:|||.|..|...|.|.|:|||||..|||||.|:|.....||||.....|.
  Fly   330 S--GYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTPTTAIISEMSL-------- 384

  Fly   433 INNNYAYGGPDSTRSIYAQDKNTRYQSN-LNEIGLSEQKSFLDKTQ-NPLLANGNANEADAESNG 495
            :|.:|     |..|    :.:|....:| |.:.|:.|.:   |..| |....||:.|:....:..
  Fly   385 LNRSY-----DGKR----RHRNKFDSANALPDYGVEEWR---DGAQGNNAGNNGDNNQTPVRNPP 437

  Fly   496 ARGHNPSMAIAWLFVVIATLLLTIRS 521
            ...||.:.::| ...::|.::|.|::
  Fly   438 GAFHNSAGSLA-QHNLLAKIMLGIKT 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	47/95 (49%)
		Ig	130..200	CDD:143165	34/69 (49%)
		I-set	226..310	CDD:254352	44/83 (53%)
		IGc2	233..298	CDD:197706	33/64 (52%)
		Ig	313..410	CDD:299845	52/101 (51%)
		IG_like	325..410	CDD:214653	43/89 (48%)
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	47/94 (50%)
		IG_like	82..174	CDD:214653	47/94 (50%)
		IG_like	184..267	CDD:214653	44/83 (53%)
		IGc2	191..255	CDD:197706	33/64 (52%)
		IG_like	282..368	CDD:214653	42/87 (48%)
		Ig	288..367	CDD:143165	39/80 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442842
Domainoid	1	1.000	56	1.000	Domainoid score	I10955
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102261at50557
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	9	8.850