DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and Prtg

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001032740.2	Gene:	Prtg / 315806	RGDID:	1307157	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	102/442 - (23%)
Similarity:	164/442 - (37%)	Gaps:	114/442 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ANVPTSNLNIVVEEPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVIT 163
            |::..|.::.....|..||      ||.|...:..|.:.:.....:.| .|.::|:....:..:|
  Rat   121 AHLTLSTISAFEVHPVSTE------VPEGGVARFSCKISSTPPAVITW-EFNRTALPMTMDSRVT 178

  Fly   164 RNPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVTAK---------------TQFGYLN 213
            ..|             :..|.|.:...||.|:|.|...|...|               |:..|:.
  Rat   179 ALP-------------SGVLQIYDAGPEDAGKYRCVAATHAHKRKSMEASLTIVPANETRSFYMP 230

  Fly   214 VVV--PPNIDDSLSSSDVIVREGANISLRCRASGSPRPIIKWKRDD-------NSRIAINKNHIV 269
            .::  |.|:..||..:         :.|.|.|:|.|:|||.|.|.|       |:|:..|.|.|:
  Rat   231 TIIASPQNVTASLHQT---------VVLECMATGYPKPIISWSRLDHKSIDVFNTRVLGNGNLII 286

  Fly   270 NEWEGDTLEITRISRLDMGAYLCIASNGVPPTVSKRI---KVSVDFPPMLLIPHQLVGAPEGFNV 331
            ::          :.....|.|:|.|:  .|.|.:..:   .::|..||..:...:.:..|.....
  Rat   287 SD----------VKLQHAGVYVCRAT--TPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTA 339

  Fly   332 TIECFTEAHPTSLNYWTRGEGPIIHDSHKYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAK 396
            ...|..|..|:....|.: .|..||.:.:.|:        |.:  ||.|..:...||.||:|:|:
  Rat   340 RFVCQAEGIPSPKMSWLK-NGRRIHSNGRIKM--------YNS--KLVINQIIPEDDAIYQCMAE 393

  Fly   397 NPRGETDGIIRL------------YVSYPPTTASSGI--------YSTD------THWGE-NGIN 434
            |.:|......||            |..:..|.:||.|        |::|      .|:.: .|:|
  Rat   394 NSQGSVLSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLN 458

  Fly   435 NN--YAYGGPDSTRSI---YAQDKN-TRYQSNLNEIGLSEQKSFLDKTQNPL 480
            |.  ....|.|:|..|   ...|.| |.|......:|.|:....:  |||.|
  Rat   459 NEEYQVVLGNDTTHYIIDDLEPDSNYTFYIVAYMPMGASQMSDHV--TQNTL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	20/110 (18%)
		Ig	130..200	CDD:143165	13/69 (19%)
		I-set	226..310	CDD:254352	22/93 (24%)
		IGc2	233..298	CDD:197706	20/71 (28%)
		Ig	313..410	CDD:299845	25/108 (23%)
		IG_like	325..410	CDD:214653	23/96 (24%)
Prtg	NP_001032740.2	Ig	32..124	CDD:416386	1/2 (50%)
		Ig strand A	32..35	CDD:409353
		Ig strand A'	38..44	CDD:409353
		Ig strand B	48..58	CDD:409353
		Ig strand C	62..68	CDD:409353
		Ig strand C'	70..73	CDD:409353
		Ig strand D	78..83	CDD:409353
		Ig strand E	85..91	CDD:409353
		Ig strand F	103..110	CDD:409353
		Ig strand G	114..124	CDD:409353	1/2 (50%)
		Ig	131..218	CDD:416386	21/106 (20%)
		Ig strand B	146..150	CDD:409353	0/3 (0%)
		Ig strand C	159..163	CDD:409353	1/4 (25%)
		Ig strand E	183..187	CDD:409353	1/3 (33%)
		Ig strand F	197..202	CDD:409353	2/4 (50%)
		Ig strand G	211..214	CDD:409353	0/2 (0%)
		Ig_3	230..302	CDD:404760	23/90 (26%)
		Ig strand B	247..251	CDD:409353	1/3 (33%)
		Ig strand C	260..264	CDD:409353	2/3 (67%)
		Ig strand E	282..286	CDD:409353	1/3 (33%)
		Ig strand F	296..301	CDD:409353	2/4 (50%)
		I-set	322..407	CDD:400151	24/95 (25%)
		Ig strand C	352..357	CDD:409353	1/4 (25%)
		Ig strand C'	359..362	CDD:409353	1/2 (50%)
		Ig strand D	367..371	CDD:409353	1/11 (9%)
		Ig strand E	373..378	CDD:409353	2/6 (33%)
		Ig strand F	387..394	CDD:409353	4/6 (67%)
		Ig strand G	398..407	CDD:409353	2/8 (25%)
		FN3	414..507	CDD:238020	23/94 (24%)
		FN3	512..605	CDD:238020
		fn3	619..694	CDD:394996
		FN3	721..809	CDD:238020
		FN3	816..906	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100