DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and Kirrel1

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_006232737.1	Gene:	Kirrel1 / 310695	RGDID:	727883	Length:	805	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	101/431 - (23%)
Similarity:	158/431 - (36%)	Gaps:	89/431 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EPEFTEYIENVTVPAGRNVKLGCSVKN---------------LGSYKVAWMHFEQSAILTVHNHV 161
            :..|::...:.||.||....|.|.:.|               :|....||
  Rat    52 QTRFSQEPADQTVVAGHRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAW--------------- 101

  Fly   162 ITRNPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSS 226
                ||..|........  :.|.|.:....|...|.||......:::...|.|::||. |..:..
  Rat   102 ----PRYRVVGSADAGQ--YNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPE-DTRIDG 159

  Fly   227 SDVI-VREGANISLRCRA-SGSPRPIIKWKRDDNSRI-AINKNHIVNEWEGDTLEITRI----SR 284
            ..|| ::.|...:|.||| :..|...|.|.||...:. |:....::.:.:.:| .|:::    :.
  Rat   160 GPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRET-TISQLLIQPTD 223

  Fly   285 LDMG-AYLCIASN-GVPPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNY- 346
            ||:| .:.|.:.| .:|......|::.|..||.:.:..:.....||..|...|...|:|..|.|
  Rat   224 LDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYR 288

  Fly   347 WTRGEGPIIHDSHKYKVEATVGLPAYKTHMKLTIIN-VSSGDDGIYKCVAKNPRGETDGIIRLYV 410
            |.:| |.:|.|:|:.:.|..|....:...:...:.| |.|.:......|...||         .|
  Rat   289 WAKG-GFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPR---------IV 343

  Fly   411 SYP-PTTASSGIYSTDT-HWGENGINNNYAYGGPDSTRSIYAQDKN--TRYQSNLNEIGLSEQKS 471
            .|| |||...|...|.| .|          .|.|..|.:...:|.|  .|...:..|..||.|
  Rat   344 VYPKPTTTDIGSDVTLTCVW----------VGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQ-- 396

  Fly   472 FLDKTQNPLLANGN------ANEADAESNGARGHNPSMAIA 506
                    :|:|.|      ..:|||.:...|...|.:.:|
  Rat   397 --------VLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVA 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	21/110 (19%)
		Ig	130..200	CDD:143165	14/84 (17%)
		I-set	226..310	CDD:254352	22/92 (24%)
		IGc2	233..298	CDD:197706	18/72 (25%)
		Ig	313..410	CDD:299845	24/98 (24%)
		IG_like	325..410	CDD:214653	22/86 (26%)
Kirrel1	XP_006232737.1	I-set	54..148	CDD:254352	21/114 (18%)
		Ig	57..148	CDD:299845	20/111 (18%)
		Ig2_KIRREL3-like	170..251	CDD:143236	19/81 (23%)
		I-set	255..336	CDD:254352	20/81 (25%)
		Ig_2	259..337	CDD:290606	19/78 (24%)
		Ig_2	340..437	CDD:290606	31/119 (26%)
		IG_like	346..437	CDD:214653	27/104 (26%)
		Ig5_KIRREL3	439..536	CDD:143306
		IG_like	451..536	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900