DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-zeta and ttn-1

DIOPT Version :10

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001346715.1	Gene:	ttn-1 / 266969	WormBaseID:	WBGene00006436	Length:	15188	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	87/349 - (24%)
Similarity:	135/349 - (38%)	Gaps:	68/349 - (19%)

- Green bases have known domain annotations that are detailed below.

Fly 87 VGSNGVIVAGGGANVPTSNLNIVVEE----PEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWM 147
||.|.. |.....:.|.:|:.: |.|.:.:.:|.......:||..:::...:.::.|.
Worm 13098 VGKNAF-----GECESEAKLTVVIPDGQYAPSFGKQLSDVKCSESDILKLEVNIQANPAPEINWF 13157

Fly 148 HFEQSAILTVHNHVITRNPRISVTHDKHDRHR------TWYLHINNVHEEDRGRYMCQINTVTAK 206
..|. .:.|.:|.|.: .:.|.|.:.:.||.|.|.| .||
Worm 13158 RNES-----------------EIEHSQHHRLQFDDGSGNYSLTIIDAYAEDSGEYKC-----VAK 13200

Fly 207 TQFGYLNVVVPPNIDDSLSS-SDVI-----------------VREGANISLRCRASGSPRPIIKW 253
.:.|..:.|....|::.||. |..| |.:||:::|.|..||:|.|.|||
Worm 13201 NKIGKAHTVCCVRIEELLSKRSKKIDGSKAPRFRMQLPTPREVPQGADLTLVCSVSGTPHPNIKW 13265

Fly 254 KRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASN--GVPPTVS-KRIKVSVD---F 312
.:||.. |.::...:.:|....||.|......|.|.|:|.|.| ||..:.| ..||.:|| .
Worm 13266 TKDDKP-IDMSNKQVRHENGVCTLHIIGARDDDQGRYVCEAENIHGVAQSFSVVEIKEAVDKDHV 13329

Fly 313 PPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGPIIHDSHKYKVEATVGLPAYKTHMK 377
.|..|.|.......||..:.:||.....|.....|.:....:|.::...:.....|: .:
Worm 13330 RPKFLEPLVNCSTCEGNEMVLECCVTGKPIPTITWYKDGLKLIIENRMLQYTDRKGV------SR 13388

Fly 378 LTIINVSSGDDGIYKCVAKNPRGE 401
|.|:||...|||.|.|.|.|..|:
Worm 13389 LNIMNVVMNDDGEYTCEAVNSLGK 13412

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	18/101 (18%)
		Ig strand B	130..134	CDD:409405	2/3 (67%)
		Ig strand C	143..147	CDD:409405	0/3 (0%)
		Ig strand E	178..185	CDD:409405	1/12 (8%)
		IgI_1_MuSK	218..310	CDD:409562	35/112 (31%)
		Ig strand A	218..221	CDD:409562	0/2 (0%)
		Ig strand A'	226..231	CDD:409562	2/22 (9%)
		Ig strand B	237..244	CDD:409562	2/6 (33%)
		Ig strand C	250..255	CDD:409562	3/4 (75%)
		Ig strand C'	257..259	CDD:409562	1/1 (100%)
		Ig strand D	267..270	CDD:409562	0/2 (0%)
		Ig strand E	275..281	CDD:409562	3/5 (60%)
		Ig strand F	288..295	CDD:409562	3/6 (50%)
		Ig strand G	302..310	CDD:409562	3/8 (38%)
		IG_like	325..410	CDD:214653	20/77 (26%)
		Ig strand B	331..335	CDD:143207	0/3 (0%)
		Ig strand C	344..348	CDD:143207	0/3 (0%)
		Ig strand E	376..380	CDD:143207	1/3 (33%)
		Ig strand F	390..395	CDD:143207	2/4 (50%)
		Ig strand G	403..406	CDD:143207
ttn-1	NP_001346715.1	IG_like	105..177	CDD:214653
		Ig strand B	107..111	CDD:409353
		Ig strand C	120..124	CDD:409353
		Ig strand E	146..150	CDD:409353
		Ig strand F	157..162	CDD:409353
		Ig_3	205..280	CDD:464046
		Ig	406..493	CDD:472250
		Ig strand B	424..428	CDD:409353
		Ig strand C	437..441	CDD:409353
		Ig strand E	462..466	CDD:409353
		Ig strand F	474..479	CDD:409353
		Ig strand G	487..490	CDD:409353
		Ig	821..914	CDD:472250
		Ig strand B	838..842	CDD:409353
		Ig strand C	851..855	CDD:409353
		Ig strand E	880..884	CDD:409353
		Ig strand F	894..899	CDD:409353
		Ig strand G	907..910	CDD:409353
		Ig	962..1030	CDD:409353
		Ig strand B	962..966	CDD:409353
		Ig strand C	975..979	CDD:409353
		Ig strand E	1000..1005	CDD:409353
		Ig strand F	1015..1020	CDD:409353
		Ig	1135..1215	CDD:472250
		Ig strand B	1152..1156	CDD:409353
		Ig strand C	1165..1169	CDD:409353
		Ig strand E	1190..1194	CDD:409353
		Ig strand F	1204..1209	CDD:409353
		Ig strand G	1217..1220	CDD:409353
		I-set	1679..1767	CDD:400151
		Ig strand B	1696..1700	CDD:409353
		Ig strand C	1709..1713	CDD:409353
		Ig strand E	1734..1738	CDD:409353
		Ig strand F	1748..1753	CDD:409353
		IG_like	1789..>1844	CDD:214653
		Ig strand B	1789..1793	CDD:409353
		Ig strand C	1801..1805	CDD:409353
		Ig strand E	1829..1833	CDD:409353
		Ig strand F	1843..1847	CDD:409353
		Ig strand G	1856..1859	CDD:409353
		PHA03247	<1957..2285	CDD:223021
		Ig	2381..2468	CDD:472250
		Ig strand B	2398..2402	CDD:409353
		Ig strand C	2411..2415	CDD:409353
		Ig strand E	2437..2441	CDD:409353
		Ig strand F	2451..2456	CDD:409353
		Ig strand G	2464..2467	CDD:409353
		Ig	2489..2578	CDD:472250
		Ig strand B	2507..2511	CDD:409353
		Ig strand C	2520..2524	CDD:409353
		Ig strand E	2544..2548	CDD:409353
		Ig strand F	2558..2563	CDD:409353
		Ig strand G	2573..2576	CDD:409353
		Ig	2631..2717	CDD:472250
		Ig strand B	2647..2651	CDD:409353
		Ig strand C	2660..2664	CDD:409353
		Ig strand E	2685..2689	CDD:409353
		Ig strand F	2698..2703	CDD:409353
		Ig strand G	2711..2714	CDD:409353
		Ig	2749..2806	CDD:472250
		Ig strand B	2749..2752	CDD:409353
		Ig strand C	2761..2765	CDD:409353
		Ig strand E	2784..2787	CDD:409353
		Ig strand F	2795..2800	CDD:409353
Ig strand B	2836..2846	CDD:409353
Ig	<2848..2913	CDD:472250
Ig strand C	2855..2859	CDD:409353
Ig strand E	2877..2881	CDD:409353
Ig strand F	2893..2898	CDD:409353
Ig strand G	2906..2909	CDD:409353
Ig	2924..3007	CDD:472250
rne	<3161..3303	CDD:236766
rne	<3356..3556	CDD:236766
rne	<3506..3673	CDD:236766
rne	<3595..3803	CDD:236766
rne	<3722..3912	CDD:236766
rne	<3875..4073	CDD:236766
PRK10263	<4014..>4556	CDD:236669
rne	<4346..4567	CDD:236766
rne	<4525..4723	CDD:236766
rne	<4746..4936	CDD:236766
rne	<4858..5044	CDD:236766
PRK10263	<4960..>5541	CDD:236669
PTZ00121	<5525..6250	CDD:173412
PTZ00121	<6198..6681	CDD:173412
tolA	<6559..>6683	CDD:236545
Ig	7448..7535	CDD:472250
Ig strand B	7466..7470	CDD:319246
Ig strand C	7479..7483	CDD:319246
Ig strand E	7502..7506	CDD:319246
FN3	<7516..7762	CDD:442628
Ig strand F	7516..7521	CDD:319246
Ig strand G	7529..7532	CDD:319246
FN3	7540..7630	CDD:238020
PTZ00121	<7944..8780	CDD:173412
Ig	8875..>8935	CDD:472250
Ig strand B	8884..8887	CDD:409353
Ig strand C	8895..8899	CDD:409353
Ig strand E	8921..8925	CDD:409353
FN3	9052..9142	CDD:238020
PTZ00121	<9210..9875	CDD:173412
PTZ00121	<9583..10392	CDD:173412
IG_like	10597..>10662	CDD:214653
Ig strand B	10608..10612	CDD:409353
Ig strand C	10622..10626	CDD:409353
Ig strand E	10647..10651	CDD:409353
Ig strand F	10661..10666	CDD:409353
Ig strand G	10670..10673	CDD:409353
Ig	<10711..10773	CDD:472250
Ig strand C	10712..10716	CDD:409353
Ig strand E	10739..10743	CDD:409353
Ig strand F	10753..10758	CDD:409353
FN3	<10754..>10967	CDD:442628
Ig strand G	10766..10769	CDD:409353
FN3	10984..11070	CDD:238020
Ig	11077..11165	CDD:472250
Ig strand B	11094..11098	CDD:409353
Ig strand C	11107..11111	CDD:409353
Ig strand E	11133..11137	CDD:409353
Ig strand F	11147..11152	CDD:409353
Ig strand G	11160..11163	CDD:409353
Ig	11183..11254	CDD:472250
Ig strand B	11190..11194	CDD:409353
Ig strand C	11202..11206	CDD:409353
Ig strand E	11227..11231	CDD:409353
Ig strand F	11241..11246	CDD:409353
Ig strand G	11250..11253	CDD:409353
Ig	11264..11350	CDD:472250
Ig strand B	11282..11286	CDD:409353
Ig strand C	11294..11298	CDD:409353
Ig strand E	11317..11324	CDD:409353
Ig strand G	11345..11348	CDD:409353
Ig	11368..11446	CDD:472250
FN3	<11450..>11657	CDD:442628
Ig	11823..11903	CDD:472250
Ig	11918..11996	CDD:472250
Ig strand B	11926..11930	CDD:409353
Ig strand C	11938..11942	CDD:409353
Ig strand E	11963..11968	CDD:409353
Ig strand F	11978..11983	CDD:409353
FN3	<11979..12306	CDD:442628
Ig strand G	11991..11994	CDD:409353
Ig	12335..12411	CDD:472250
Ig strand B	12338..12342	CDD:409353
Ig strand C	12351..12356	CDD:409353
Ig strand E	12377..12381	CDD:409353
Ig strand F	12391..12396	CDD:409353
Ig strand G	12404..12407	CDD:409353
FN3	12415..12503	CDD:238020
Protein Kinases, catalytic domain	12566..12815	CDD:473864
I-set	12894..12985	CDD:400151
Ig strand B	12912..12916	CDD:409353
Ig strand C	12925..12929	CDD:409353
Ig strand E	12951..12955	CDD:409353
Ig strand F	12965..12970	CDD:409353
Ig	13024..13114	CDD:472250	5/20 (25%)
Ig strand B	13041..13045	CDD:409353
Ig strand C	13054..13058	CDD:409353
Ig strand E	13080..13084	CDD:409353