DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and Kirrel2

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	337	Identity:	80/337 - (23%)
Similarity:	129/337 - (38%)	Gaps:	72/337 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PEFTEYIENVTVPAGRNVKLGCSVKNLGSYK--VAWMHFEQSAILTVHNHVITRNP-RISVTHDK 174
            |.|.:..|::.|..|...:|.|:   ||:|:  |.|                |::. .:....|.
Mouse    21 PHFLQQPEDMVVLLGEEARLPCA---LGAYRGLVQW----------------TKDGLALGGERDL 66

  Fly   175 HDRHRTWY----------LHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDV 229
            ....|.|.          |||..|..||...|.||.:....:::...|:|:|||.....|....|
Mouse    67 PGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSV 131

  Fly   230 IVREGANISLRCRASGS--PRPIIKWKRD----DNSRIAINKNHIVNEWEG---DTLEITRISRL 285
            .:..|...:|.||:.|.  |.|.:.|.||    |.|  :.::..:.::..|   :||.:|..|..
Mouse   132 SLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGS--SFHQTTLKDKATGTVENTLFLTPSSHD 194

  Fly   286 DMGAYLCIA-SNGVPPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNY-WT 348
            |....:|.| |..:|......:.:|:.:|||:.:..:.....||..||..|...|.|....| |.
Mouse   195 DGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWA 259

  Fly   349 RGEGPI----------------IHDSHKYKVEATVGLPAYKTHMKLTI----------INVSSGD 387
            :|..|:                :.:....:|...||.....|.:::..          ::|..|.
Mouse   260 KGGSPVLGARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVSVDVGK 324

  Fly   388 DGIYKCVAK-NP 398
            |..:.||.: ||
Mouse   325 DASFSCVWRGNP 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	25/108 (23%)
		Ig	130..200	CDD:143165	19/82 (23%)
		I-set	226..310	CDD:254352	23/93 (25%)
		IGc2	233..298	CDD:197706	21/74 (28%)
		Ig	313..410	CDD:299845	25/114 (22%)
		IG_like	325..410	CDD:214653	22/102 (22%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	24/107 (22%)
		Ig	122..220	CDD:416386	24/99 (24%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	1/3 (33%)
		Ig strand B	140..147	CDD:409353	3/6 (50%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	1/8 (13%)
		Ig strand E	180..188	CDD:409353	3/7 (43%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	15/68 (22%)
		Ig strand B	241..245	CDD:409353	2/3 (67%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	0/8 (0%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	7/22 (32%)
		Ig strand A'	316..321	CDD:409353	0/4 (0%)
		Ig strand B	324..333	CDD:409353	3/8 (38%)
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900