DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-zeta and SDK1

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_689957.3	Gene:	SDK1 / 221935	HGNCID:	19307	Length:	2213	Species:	Homo sapiens

Alignment Length:	625	Identity:	143/625 - (22%)
Similarity:	207/625 - (33%)	Gaps:	203/625 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLVLAATAGDSTNKIILPQILNGGGG------------GGGVGTAQGKHPSGSKTVATGVVPNFG 64
            |::||.|..|:....:  |.:|...|            ...|||.:...|       |.|||
Human   246 LVILATTTSDAGAYYV--QAVNEKNGENKTSPFIHLSIARDVGTPETMAP-------TIVVP--- 298

  Fly    65 GAAGNGAGGGGPVAGSG-TGSTVVGS-------------NGVIVAGG----GANVPTSN------ 105
                  .|....||||. |....:.|             |||.:..|    |..:..||
Human   299 ------PGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADT 357

  Fly   106 ---------------------LNIVVEEPEFTEYIEN-VTVPAGRNVKLGCSVKNLGSYKVAWMH 148
                                 ...::|.|.||...|: ::......|.:||....:....:.|.
Human   358 GPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWY- 421

  Fly   149 FEQSAILTVHNHVITR--NPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMC-------QINTVT 204
              :.||      .|:|  |||..|.       .:..|.|..:..||.|.:.|       :|.|.|
Human   422 --KDAI------SISRLQNPRYKVL-------ASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHT 471

  Fly   205 AKTQFGYLNVVVPPNIDDSLSSS--DVIVREGANISLRCRASGSPRPIIKWKRDDNSRIAINKNH 267
                  ||:|.   ||....:..  |..|.:|....|||..||:|:|.|.|||:         ||
Human   472 ------YLDVT---NIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRE---------NH 518

  Fly   268 IVNE----------WEGDTLEITRISRLDMGAYLCIASN-----GVPPTVSKRIKVSVDFPPMLL 317
            |:..          .|...|:|..:...|.|.|.|.|:|     ....|::...:.|:..||.
Human   519 ILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPE-- 581

  Fly   318 IPHQLVGAPEGFNVTIECFTEAHP-TSLNY-WTRGEGPIIHDSHKYKVEATVGLPAYKTHMKLTI 380
             .|.::   :|...|:.|.....| .||.| |.:....:...|....|....|        .|.|
Human   582 -DHVVI---KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDG--------SLLI 634

  Fly   381 INVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPP--------TTASSGIYSTDTHW-----GENG 432
            ....|||.|.|.|...:..|....:.||.|...|        :..||..::....|     |.:.
Human   635 SQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSP 699

  Fly   433 I--------NNNYAYG------GPDSTR-SIYAQDKNTRYQSN---LNEIG---LSEQKSFLDKT 476
            |        .||..:.      ||:.|. ::........||..   :||:|   .|.:.|.|...
Human   700 ILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLP 764

  Fly   477 QNP-------LLANGNANEA---------DAESNGA-RGH 499
            :.|       ::|:|..|::         :.|.||. ||:
Human   765 EEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	25/105 (24%)
		Ig	130..200	CDD:143165	18/78 (23%)
		I-set	226..310	CDD:254352	27/100 (27%)
		IGc2	233..298	CDD:197706	24/79 (30%)
		Ig	313..410	CDD:299845	25/98 (26%)
		IG_like	325..410	CDD:214653	22/86 (26%)
SDK1	NP_689957.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		I-set	104..188	CDD:254352
		Ig	122..176	CDD:143165
		Ig	219..265	CDD:299845	6/20 (30%)
		IGc2	312..364	CDD:197706	8/51 (16%)
		I-set	386..475	CDD:254352	27/110 (25%)
		Ig	404..472	CDD:143165	21/89 (24%)
		I-set	480..570	CDD:254352	27/98 (28%)
		Ig	494..570	CDD:299845	25/84 (30%)
		I-set	575..664	CDD:254352	26/102 (25%)
		Ig	580..664	CDD:299845	24/97 (25%)
		FN3	668..759	CDD:238020	17/90 (19%)
		fn3	771..857	CDD:278470	8/34 (24%)
		FN3	872..967	CDD:238020
		FN3	972..1054	CDD:238020
		FN3	1070..1166	CDD:238020
		FN3	1176..1271	CDD:238020
		fn3	1279..1365	CDD:278470
		FN3	1378..1471	CDD:238020
		FN3	1477..1572	CDD:238020
		FN3	1580..1694	CDD:238020
		FN3	1704..1797	CDD:238020
		FN3	1802..1883	CDD:238020
		FN3	1903..1996	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2075..2098
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2207..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810