DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and lsamp

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_031751462.1	Gene:	lsamp / 100124984	XenbaseID:	XB-GENE-5759171	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	369	Identity:	109/369 - (29%)
Similarity:	162/369 - (43%)	Gaps:	58/369 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VPTSNLNIVVEEPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRN 165
            :||   .:.|...:|....:|:||..|....|.|.|::..| :|||::  :|.|:...:...:.:
Frog    23 LPT---GLPVRSGDFNRSTDNITVRQGDTAILRCFVEDRSS-RVAWLN--RSGIIFAGDDKWSLD 81

  Fly   166 PRISVTHDKHDRHRTWY-LHINNVHEEDRGRYMCQINTVT-AKTQFGYLNVVVPPNIDDSLSSSD 228
            ||:.:    ..|....| |.|..|...|.|.|.|.:.|.. .||...||.|.|||.|  |..|:|
Frog    82 PRVEL----EKRSLLEYSLRIQKVDVSDEGPYTCSVQTKQHTKTTQVYLIVQVPPKI--SNISAD 140

  Fly   229 VIVREGANISLRCRASGSPRPIIKWKRDDNSRIAINKNHI--------VNEWEGDT--LEITRIS 283
            :.|.||:|::|.|.|.|.|.|:|.|:            |:        ..::||:.  |||..|:
Frog   141 ITVNEGSNVTLMCIAYGRPEPMITWR------------HLTPTAGTSPARDFEGEEEFLEIQGIT 193

  Fly   284 RLDMGAYLCIASNGVPPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWT 348
            |...|.|.|.|:|.|.....|:::|:|::|| ::...:...|..|....:.|...|.|.....|.
Frog   194 REQSGRYECKAANEVASADVKQVRVTVNYPP-IITESKSNEATTGKQAILRCEASAVPAPDFEWY 257

  Fly   349 RGEGPIIHDSHKYKVEATVGLPAYKTHMK--LTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVS 411
            :      .|:...::.:..||....|..:  |.:.||:....|.|.|||.|..|.|:..:.||..
Frog   258 K------DDTRSRRINSAQGLEIRNTGSRSVLMVANVTEEHYGNYTCVAANKLGITNTSLYLYKR 316

  Fly   412 YPPTTASSGIYSTDTHWGENGINNNYAY----GGP-DSTRSIYA 450
            ..||...|.        .|.|.|.:|.|    |.| ||..|:.|
Frog   317 VSPTKPMSA--------SERGSNVHYQYKVGPGTPIDSATSLAA 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	30/97 (31%)
		Ig	130..200	CDD:143165	20/70 (29%)
		I-set	226..310	CDD:254352	30/93 (32%)
		IGc2	233..298	CDD:197706	24/74 (32%)
		Ig	313..410	CDD:299845	24/98 (24%)
		IG_like	325..410	CDD:214653	22/86 (26%)
lsamp	XP_031751462.1	Ig	38..128	CDD:416386	29/96 (30%)
		FR1	38..54	CDD:409353	5/15 (33%)
		Ig strand A'	39..45	CDD:409353	3/5 (60%)
		Ig strand B	47..55	CDD:409353	2/7 (29%)
		CDR1	55..59	CDD:409353	1/3 (33%)
		FR2	60..67	CDD:409353	4/9 (44%)
		Ig strand C	60..66	CDD:409353	4/6 (67%)
		CDR2	68..78	CDD:409353	2/9 (22%)
		Ig strand C'	70..73	CDD:409353	1/2 (50%)
		Ig strand C'	75..78	CDD:409353	0/2 (0%)
		FR3	79..114	CDD:409353	11/38 (29%)
		Ig strand D	83..90	CDD:409353	1/10 (10%)
		Ig strand E	93..99	CDD:409353	2/5 (40%)
		Ig strand F	106..114	CDD:409353	3/7 (43%)
		CDR3	115..119	CDD:409353	1/3 (33%)
		Ig strand G	119..128	CDD:409353	4/8 (50%)
		FR4	121..128	CDD:409353	3/6 (50%)
		Ig_3	131..206	CDD:404760	30/88 (34%)
		Ig strand A'	138..143	CDD:409353	2/4 (50%)
		Ig strand B	149..156	CDD:409353	2/6 (33%)
		Ig strand C	162..167	CDD:409353	2/16 (13%)
		Ig strand C'	173..175	CDD:409353	0/1 (0%)
		Ig strand E	185..191	CDD:409353	3/5 (60%)
		Ig strand F	198..205	CDD:409353	3/6 (50%)
		Ig strand G	212..220	CDD:409353	2/7 (29%)
		Ig_3	223..302	CDD:404760	20/85 (24%)
		putative Ig strand A	224..230	CDD:409353	1/6 (17%)
		Ig strand B	240..244	CDD:409353	0/3 (0%)
		Ig strand C	253..257	CDD:409353	0/3 (0%)
		Ig strand E	281..285	CDD:409353	1/3 (33%)
		Ig strand F	295..300	CDD:409353	2/4 (50%)
		Ig strand G	308..311	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060