Protein Alignment IDS and Sgsh

DIOPT Version :9

• Sequence 1: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Sequence 2: NP_650760.1
• Gene: Sgsh / 42266
• FlyBaseID: FBgn0038660
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 125/547 - (22%)
• Similarity: 209/547 - (38%)
• Gaps: 142/547 - (25%)

Human    38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRL 102
            ||||::.||.....|.|.:|..::||:|.||...|||.|||...:.|:|||...|||:...::.:
  Fly    22 NVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHSSGM 86

Human   103 YDFNSYWRVHAG--NFSTIPQYFKENGYV-----TMSVGKVF-------HPGISSNHTDDSPYSW 153
            |.      :|.|  ||:.:|    :.|.:     ..|.|::.       |.|.::|...|
  Fly    87 YG------LHQGVHNFNVLP----DTGSLPNLIRDQSGGRILSGIIGKKHVGAANNFRFD----- 136

Human   154 SFPPYHPSSEKYENTKTCRGPDGELHA------NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKM 212
                       :|.|:       |.|:      |:                .:..|.|.|.|::.
  Fly   137 -----------FEQTE-------EQHSINQIGRNI----------------TRMKEYARQFLKQA 167

Human   213 KTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQ 277
            |....||||.||:|.||.......:|.:..............:||..|  .|..|.
  Fly   168 KDEKKPFFLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKP--IYYDWR--------- 221

Human   278 ALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG------ 336
              |:.||......|..|:...:.:.::|.||..||.:|..|:...:|:.|::.:|||:|
  Fly   222 --NLDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGPPFPGG 284

Human   337 -WALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDL 400
             ..|.|||           ...|||...|.:.....||...:...||.:.|....::..|.:...
  Fly   285 RTNLYEHG-----------IRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDALQIPRPNDTK 338

Human   401 VELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQ 465
            :...|:.|.|.     :.||           .:|..::.....:.::     ....|..::...:
  Fly   339 IVGRSILPVLR-----EEPP-----------IKESDSVFGSHSYHEV-----TMAYPMRMVRNRR 382

Human   466 YPRPSDIPQWNSDKPSLKDI-------KIMGYSIR--TIDYRYTVWVGFNPDEFLANFSDIHAGE 521
            |....:|..| :|.|..:|.       :|:..::|  |:.:..::...:...|:          |
  Fly   383 YKLIHNINYW-ADFPIDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEW----------E 436

Human   522 LYFVDSDPLQDHNMYNDSQ-GGDLFQL 547
            ||.:.:|||:..|:.:.:: .|.|.||
  Fly   437 LYDIKTDPLERFNLADKAKYNGTLKQL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDS	NP_000193.1	AslA	33..544	CDD:225661	122/542 (23%)
		iduronate-2-sulfatase	38..540	CDD:293754	121/537 (23%)
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	125/547 (23%)
		SGSH	22..471	CDD:293751	125/547 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810