Protein Alignment IDS and CG7402

DIOPT Version :9

• Sequence 1: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Sequence 2: NP_649023.1
• Gene: CG7402 / 39994
• FlyBaseID: FBgn0036768
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 138/569 - (24%)
• Similarity: 214/569 - (37%)
• Gaps: 169/569 - (29%)

Human     9 GLLWLGLVLSSV-CVALGSETQANSTTDALNVLLIIVDDL-RPSLGCYGDKLVRSPNIDQLASHS 71
            |.:.:.||:||: .:|.||   ..||..  |:::|::||: ...:..:|...:.:||||.||.:.
  Fly     4 GKILVLLVVSSILSLAYGS---GYSTKP--NIVIILIDDMGMNDVSFHGSNQILTPNIDALAYNG 63

Human    72 LLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDF----NSYWRVHAGNFSTIPQYFKENGYVTMS 132
            :|....:... :|.|||.:.|||:.|..|.:..|    :..|.:.... ..:|:.|::.||.|..
  Fly    64 ILLNKHYVPN-LCTPSRATLLTGKYPIHTGMQHFVIITDEPWGLPQRE-RLMPEIFRDAGYSTHL 126

Human   133 VGKVFHPGISSNHTDDSP----YSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPE 193
            ||| :|.|..  ..|.:|    :...|..|:...:.|::  ..|..|....|.|....|:...||
  Fly   127 VGK-WHLGFW--RKDLTPTMRGFDHHFGYYNGYIDYYDH--QVRMLDRNYSAGLDFRRDLEPCPE 186

Human   194 --GTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHI-----PFRYPKEFQKLYPLENITLAP 251
              ||...:..|.:|.:::|:...| .|.|:.:.:...|.     |.:.|:|          .:|.
  Fly   187 ANGTYATEAFTSEAKRIIEQHDKS-KPLFMVLSHLAVHTGNEDSPMQAPEE----------EVAK 240

Human   252 DPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLS 316
            .|.:.|  |.                                   |::|...:|.||..|.:.:.
  Fly   241 FPHIRD--PK-----------------------------------RRTYAGMISSLDKSVAQTIG 268

Human   317 ALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYL 381
            ||.|..:.|::||...||:|                    .|.|.......::.|..|:|..|:.
  Fly   269 ALKDNGMLNNSIILLYSDNG--------------------APTIGIHSNAGSNYPYRGQKESPWE 313

Human   382 DPFDSASQLMEP-----GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKH 441
            ....||..|..|     |..|...:..|...|||||.||:.:|...|:         :|.||.
  Fly   314 GGIRSAGALWSPLLKERGYVSNQAIHAVDWLPTLAGAAGVSLPQDLPL---------DGINLW-- 367

Human   442 FRFRDLEEDPYLPGN----PR-------ELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTI 495
                     |.|.||    ||       |:..||.|.|           .:||.:.  |.|.:.
  Fly   368 ---------PMLSGNEEPKPRTMIHVLDEVFGYSSYMR-----------DTLKYVN--GSSFKG- 409

Human   496 DYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPL----QDHNMYNDSQ 540
              ||..|:                |||...:.|||    :.|.:.:|.|
  Fly   410 --RYDQWL----------------GELETNEDDPLGESYEQHVLASDVQ 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDS	NP_000193.1	AslA	33..544	CDD:225661	129/544 (24%)
		iduronate-2-sulfatase	38..540	CDD:293754	127/537 (24%)
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	130/545 (24%)
		4-S	28..436	CDD:293753	126/536 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810