Protein Alignment IDS and CG18278

DIOPT Version :10

• Sequence 1: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Sequence 2: NP_725289.1
• Gene: CG18278 / 36487
• FlyBaseID: FBgn0033836
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 129/561 - (22%)
• Similarity: 210/561 - (37%)
• Gaps: 139/561 - (24%)

Human    15 LVLSSVCVALGSETQANSTTDAL-NVLLIIVDDLRPSL-GCYGDKLVRSPNIDQLASHSLLFQNA 77
            ::|...|:       .|:.::.| |:|||:.||....| |.:    .....|:.|.....||.||
  Fly     8 IILVLACL-------GNTASEKLPNILLILSDDQDVELRGMF----PMEHTIEMLGFGGALFHNA 61

Human    78 FAQQAVCAPSRVSFLT-------GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGK 135
            :....:|.|:|.|.||       |.|.::.....:..:|| .|.....:|...:::||.|...||
  Fly    62 YTPSPICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWR-RALEPRALPYILQQHGYNTFFGGK 125

Human   136 VFHPGISSNHTDDSPYSWS-FPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDK 199
            ..:....:.   |.|..|: |...|.:|..|  ..|.|...|.:|.......|:|
  Fly   126 YLNQYWGAG---DVPKGWNHFYGLHGNSRYY--NYTLRENSGNVHYESTYLTDLL---------- 175

Human   200 QSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPF----RYPKEFQKLYPLENITLAPDPEVPDGLP 260
              .::|...|.....|:.|||..|.....|.||    |:...|..:               :.|.
  Fly   176 --RDRAADFLRNATQSSEPFFAMVAPPAAHEPFTPAPRHEGVFSHI---------------EALR 223

Human   261 PVAYNP------WMDIR--QREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSA 317
            ..::|.      |: :|  :|...:.:|....|      ||::     :.::..:|..|..|:..
  Fly   224 TPSFNQVKQDKHWL-VRAARRLPNETINTIDTY------FQKR-----WETLLAVDELVVTLMGV 276

Human   318 LDDLQLANSTIIAFTSDHGWALGEHGE-WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYL 381
            |:|.|...:|.|.:|||:|:.:|:..: :.|...::...:|||:...||   ..||:
  Fly   277 LNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVPLLIRGPG---IAPES-------- 330

Human   382 DPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRD 446
             ..|:|             |.||.|.||:...|.:..|......||| ||....:..:..|....
  Fly   331 -HIDTA-------------VSLVDLAPTILAWADIDTPSYMDGQSFH-ELLLNKRRRVPFFERSL 380

Human   447 LEE----------DPYLPGNPRELIAYSQYPRPSDI---PQWNSDKPSLKDIKIMGYSIRTIDYR 498
            |.|          :|..|...::.:|  |....:|.   ..||:....|::|:          :|
  Fly   381 LIEYWGEGTLATFNPECPWPEKDRLA--QCTPAADCHCQDAWNNTYACLRNIR----------HR 433

Human   499 Y-TVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYND 538
            . .::..|..:|   ||.     |.|.:..||.|..|:..|
  Fly   434 EDRIYCEFRDNE---NFL-----EAYDLQLDPFQMTNIAYD 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDS	NP_000193.1	iduronate-2-sulfatase	38..540	CDD:293754	125/537 (23%)
CG18278	NP_725289.1	G6S	24..467	CDD:293766	125/538 (23%)