Protein Alignment IDS and CG32191

DIOPT Version :10

• Sequence 1: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Sequence 2: NP_730304.2
• Gene: CG32191 / 317903
• FlyBaseID: FBgn0052191
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 121/578 - (20%)
• Similarity: 198/578 - (34%)
• Gaps: 162/578 - (28%)

Human    38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTR 101
            |:::|:.||:. ..:...|.:...:||||.||.|..|....:| .|:|.|||.:.|:||.|..|.
  Fly    28 NIIIIMADDMGFDDVSFRGGREFLTPNIDALAYHGRLLDRLYA-PAMCTPSRGALLSGRYPIHTG 91

Human   102 LYDF----NSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSP----------YS 152
            ...|    ...|.:.. |.:.:|:.|||.||.|..||| :|.|.|  ..:.:|          |.
  Fly    92 TQHFVISNEEPWALTL-NATLMPEIFKEAGYSTNLVGK-WHLGFS--RPEYTPTRRGFDYHFGYW 152

Human   153 WSFPPYHPSSEKYENTKTCRGPDGELHANLLC---PVDVLDVPEGTLPDKQSTEQAIQLLEKMKT 214
            .::..|.....|........|.|...:..|.|   .|.|.|:         .|.:|.:|::....
  Fly   153 GAYIDYFQRRSKMPVANYSLGYDFRRNMELECRDRGVYVTDL---------LTAEAERLIKDHAD 208

Human   215 SASPFFLAVGYHKPHI-----PFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQRE 274
            ...|.||.:.:...|.     |.:.|:|     .::..:...||.
  Fly   209 KEQPLFLMLSHLAAHTANEDDPLQAPEE-----EIQKFSYIKDPN-------------------- 248

Human   275 DVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL 339
                                  |:.|.|.:|.||..|||:::||.......::|:.|.||:|
  Fly   249 ----------------------RRKYAAMISKLDQSVGRIITALSSTDQLENSIVIFYSDNG--- 288

Human   340 GEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
                             .|.:.......::.|..|:|..|:......|..:...|.|:...:...
  Fly   289 -----------------APSVGMFSNTGSNFPLRGQKNTPWEGGVRVAGAIWSSGLQARGSIFRQ 336

Human   405 SLF-----PTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELI-AY 463
            .|:     |||:..|.:::..         .|..:|.:|     :.:|......|..|||:: ..
  Fly   337 PLYVADWLPTLSRAADIELDS---------SLKLDGIDL-----WPELSGSADAPHVPREILHIL 387

Human   464 SQYPRPS--DIPQW---NSDKPSLKDIKIMGY----SIRTIDYRYTVWVGFNPD----------- 508
            ....|.|  .:.||   |....|.:...::.|    .:...|.||.|.|..:..
  Fly   388 DDVWRLSALQMGQWKYVNGTTASGRYDSVLTYRELDDLDPRDSRYAVTVRNSATSRALSRYDLRR 452

Human   509 ------EFLANFSDIHAGE------------LYFVDSDPLQDHNMYNDSQGGDLFQLL 548
                  ......:.:..|:            ||.:.|||.:.:|:....:..|:...|
  Fly   453 LTQQRISLTRRLAAVRCGDLQRSCNPLLEECLYDILSDPCEQNNLVYSERHSDVLTAL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDS	NP_000193.1	iduronate-2-sulfatase	38..540	CDD:293754	119/568 (21%)
CG32191	NP_730304.2	4-S	27..408	CDD:293753	105/474 (22%)