DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Try29F and prss60.3

DIOPT Version :9

Sequence 1:	NP_001285772.1	Gene:	Try29F / 34226	FlyBaseID:	FBgn0015316	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	XP_002662541.2	Gene:	prss60.3 / 335152	ZFINID:	ZDB-GENE-030131-7092	Length:	330	Species:	Danio rerio

Alignment Length:	275	Identity:	110/275 - (40%)
Similarity:	148/275 - (53%)	Gaps:	30/275 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTGMAKTILHLFIGGILLVNLSLGATVRRPRLDGRIVGGQVANIKDIPYQVSLQR-SY--HFCGG 68
            ||....|:|....|.:..:|:...|.     |:.|||||..|:....|:||||.. .|  |||||
Zfish     6 LTCATLTLLICVKGSLSQLNVCGQAP-----LNTRIVGGVNASPGSWPWQVSLHSPKYGGHFCGG 65

  Fly    69 SLIAQGWVLTAAHCTEGSAILLSKVRIGSSRTSVGGQLVGIKRVHR-------HPKFDAYTIDFD 126
            |||:..||||||||..|.:.....|.:| .||..|   :.|....|       |..:::.|.|.|
Zfish    66 SLISSEWVLTAAHCLSGVSETTLVVYLG-RRTQQG---INIYETSRNVAKSFVHSSYNSNTNDND 126

  Fly   127 FSLLELEEYSAKNVTQAF--VGLPEQDADIADGTPVLVSGWGNTQSAQETSA--VLRSVTVPKVS 187
            .:||.|.  ||...|...  |.|..|::..:.||...::|||:.|:.....|  :|:...:|.|:
Zfish   127 IALLRLS--SAVTFTNYIRPVCLAAQNSVYSAGTSSWITGWGDIQAGVNLPAPGILQETMIPVVA 189

  Fly   188 QTQCTEAYGNFGSITDRMLCAGLPEGGKDACQGDSGGPLAAD-GVLW---GVVSWGYGCARPNYP 248
            ..:|....|: |::|:.|:||||.:||||.||||||||:... ..:|   |:.|||||||.||.|
Zfish   190 NDRCNALLGS-GTVTNNMICAGLTQGGKDTCQGDSGGPMVTRLCTVWVQAGITSWGYGCADPNSP 253

  Fly   249 GVYSRVSAVRDWISS 263
            |||:|||..:.||||
Zfish   254 GVYTRVSQYQSWISS 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Try29F	NP_001285772.1	Tryp_SPc	41..261	CDD:214473	98/237 (41%)
Try29F	NP_001285772.1	Tryp_SPc	42..264	CDD:238113	101/240 (42%)
prss60.3	XP_002662541.2	Tryp_SPc	36..269	CDD:238113	101/240 (42%)
prss60.3	XP_002662541.2	Somatomedin_B	294..328	CDD:321959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900