DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Try29F and PRSS36

DIOPT Version :9

Sequence 1:	NP_001285772.1	Gene:	Try29F / 34226	FlyBaseID:	FBgn0015316	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	247	Identity:	88/247 - (35%)
Similarity:	115/247 - (46%)	Gaps:	20/247 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RPRLDGRIVGGQVANIKDIPYQVSLQR-SYHFCGGSLIAQGWVLTAAHC--TEGSAILLSKVRIG 96
            ||....|||||..|.....|:||||.. ..|.|||||||..|||:||||  |.|:....::..:.
Human    40 RPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVL 104

  Fly    97 SSRTSVGGQLVG-----IKRVHRHPKFDAYTIDFDFSLLELEEYSAKNVTQAFVGLPEQDADIAD 156
            ....|..|.|.|     :..:.....:....:..|.:||.|...::.......|.||........
Human   105 LGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVH 169

  Fly   157 GTPVLVSGWGNTQSAQETSA--VLRSVTVPKVSQTQCTEAYGNFG------SITDRMLCAGLPEG 213
            ||....:|||:.|.|.....  ||:.|.:..:.:..|...|...|      .|...|||||.|||
Human   170 GTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEG 234

  Fly   214 GKDACQGDSGGPLAA-DGVLW---GVVSWGYGCARPNYPGVYSRVSAVRDWI 261
            .:|.|||||||||.. :|..|   |:.|:|:||.|.|.|||::.|:....||
Human   235 RRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Try29F	NP_001285772.1	Tryp_SPc	41..261	CDD:214473	84/239 (35%)
Try29F	NP_001285772.1	Tryp_SPc	42..264	CDD:238113	85/240 (35%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	84/239 (35%)
		Tryp_SPc	47..289	CDD:238113	85/240 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840