DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9541 and Ak7

DIOPT Version :9

Sequence 1:	NP_001260273.1	Gene:	CG9541 / 34220	FlyBaseID:	FBgn0032083	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_084463.1	Gene:	Ak7 / 78801	MGIID:	1926051	Length:	723	Species:	Mus musculus

Alignment Length:	702	Identity:	117/702 - (16%)
Similarity:	219/702 - (31%)	Gaps:	268/702 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VTHCDTFMQERRGVTHINMMDLLQQYAMGNDMQDFSQLSSKTVTEVLMLEMKMAPAAK----AYL 142
            :.|.||:.....|....|.:.......:|.:.::..:..|....|        ||..|    .:.
Mouse    21 INHLDTYSSGNIGKFLANCVAGASLEEIGEEEEEEDETKSAVAPE--------APTTKVKEGTFQ 77

  Fly   143 ISG---YPRSMR-----------------------DVVEY--SEKIQVVNGVILISWRQSVLQKQ 179
            |.|   .|.|::                       |.|.|  :|.:|.|...:   |..|.|.::
Mouse    78 IVGTLVKPESVKPDFAVEAYKGISREDLLSHLMECDAVIYNITENVQQVEEAL---WAVSALNEE 139

  Fly   180 IDYGAK------------------------------------------LGHVVLSLAKMELENFF 202
            |.:..|                                          |.|:  :..|:.|: |.
Mouse   140 ISHFEKRKVFILLSTVMTWARSKPLDPDDNEVPFTEEDYRRRKHHPNFLDHI--NAEKIVLK-FG 201

  Fly   203 KNVMPVADYFDQSDM-------------LLAVNGERAPTEVYKDFRTA-----VLDILSTLEN-- 247
            ||....|.|...|.:             .:|..||.....|:.|....     |:|:...::|
Mouse   202 KNAKKFATYVVASGLQYGAEGGILHTFFKMAWLGEVPALPVFGDGTNCIPAIHVVDLAGVIQNII 266

  Fly   248 -QEAVMNGVTGMGRGIHDIPGSI--VSVDTAPSQAQQGTQIAEDNDVTNASETAGTVLARDLAIE 309
             ....::.:..:...:|.:...:  :|.:|.|.:.|   ::.::|          ..|.:||..|
Mouse   267 DHVPKLHYLVAVDEAVHTLEDLVKCISKNTGPGKIQ---KVPKEN----------AFLTKDLTQE 318

  Fly   310 RMDGGPNGAVTALKTGTTSADDD--------SGVVVTQQPKLRQAAGPDESGSDLPPIIWVIGGP 366
            .:|    ..:..|:.......::        :|.|......|::.   .:|...||..|.::|.|
Mouse   319 YLD----HLLVNLRMEALFVKENFNIRWVAQTGFVENINSILKEY---KQSRGLLPIKICILGPP 376

  Fly   367 GSNKATL---CLKAVGLNPGWAHISVGRLLRNITDSAPRANTESFAVKEALAA----------GD 418
            ...|:::   ..|...|:    ||.:..::           .|:.|..||:.|          |:
Mouse   377 AVGKSSISEELAKYYKLH----HIKMKDVI-----------AEAIAKLEAIVAPKDSVEGEEEGE 426

  Fly   419 MAPEK-----------SLNQLLETNLRQLRDR-----------------TGIIVDGYPRNLQQVK 455
            ...|:           .:.:.:|.|..:|.|:                 .|.|:||:|:...|.|
Mouse   427 EEEEEENVDDAQELLDGIKESMEQNAGRLEDQYIIRFVKEKLKSMPCRNQGFILDGFPKTYDQAK 491

  Fly   456 YFENKYKQR-----------------PPIIL-LDCSKLQLGRGRI-------------------- 482
            ...|:.::.                 |..:. ||.|. :..:.|:
Mouse   492 DLFNQEEEEEEEEIRGKIFPYDKLITPEFVCGLDASD-EFLKERVMNLPESVVAGTHYSQDRFLR 555

  Fly   483 -----------DDTVSSFRRRLELFREQTLPMLKILDTSNRLQIVD-----------GDTDSPSV 525
                       |:||.::...||: ....:.:.|:.|..|||.|..           |.||....
Mouse   556 SLSHYRDINTDDETVFNYFDELEI-HPIHIDVGKLEDAQNRLAIKQLIKEIGKPRNYGLTDEEKA 619

  Fly   526 QRE----FERLIRNHIQRLLNKTDDID--DSANLGNQMMRNEQTDAILHDLE 571
            :.|    .|||.:...|     |.:::  ::..:..::.|.|:.:..|.:::
Mouse   620 EEEKKAAEERLAKEAAQ-----TAELEHKEAMEMAEKIARWEEWNKRLEEVK 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9541	NP_001260273.1	aden_kin_iso1	67..238	CDD:130427	41/247 (17%)
		ADK	70..230	CDD:238713	39/234 (17%)
		aden_kin_iso1	358..521	CDD:130427	44/263 (17%)
		ADK	359..521	CDD:238713	44/262 (17%)
Ak7	NP_084463.1	WcaG	<147..297	CDD:223528	20/152 (13%)
		NADB_Rossmann	<218..298	CDD:304358	11/79 (14%)
		ADK	369..>548	CDD:238713	32/194 (16%)
		Dpy-30	679..720	CDD:253069
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830