DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9541 and ak9

DIOPT Version :9

Sequence 1:	NP_001260273.1	Gene:	CG9541 / 34220	FlyBaseID:	FBgn0032083	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_685909.5	Gene:	ak9 / 557708	ZFINID:	ZDB-GENE-041014-337	Length:	1762	Species:	Danio rerio

Alignment Length:	722	Identity:	132/722 - (18%)
Similarity:	220/722 - (30%)	Gaps:	281/722 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 MQN-----AGKIKFDPPKVPVIFVLGGPGSGKVTHCDTFMQERRGVTHINMMDLLQQY------- 107
            :||     :.|....||.:.| .:||..||||.|| ..::.::.|:.||...:.||:.
Zfish   797 LQNPELYISNKELLKPPALRV-SMLGVRGSGKTTH-GKWLAQQLGIFHIQFRERLQELIQRKTQK 859

  Fly   108 ---------------------------------------------------------AMGND--- 112
                                                                     |:..|
Zfish   860 RVSPADDSEPPEEPPEELQSLLKAQARIQSAESPTDQDNTTSLEETASGSPDAKEEEALTEDEEA 924

  Fly   113 ----MQDFSQLSSKTVTEVLMLEMKMAP-AAKAYLISGYPRSMRDV-----------------VE 155
                :|:...|.|:.:..:|.......| .:..:::.|:|::..:|                 ||
Zfish   925 IKAYLQNGDPLPSEILEMLLFQWWNQEPYKSTGFILEGFPQNHEEVSFMAEHHLFPDVVAVMSVE 989

  Fly   156 YSEKIQVVNGVILISWRQSVLQKQIDYGAKLGHVVLSLAKMELENFFKNVMPVADYFDQSDMLLA 220
            .||.::.:....|..||:...:||...     |:|:.|.|...|.                   |
Zfish   990 VSEVVRRLLPSRLNRWRERRERKQQQI-----HLVMKLRKEIRER-------------------A 1030

  Fly   221 VNGERAPTEVYKDFRTAVLDILSTLENQEAVMNGVTGMG--RGIHDIPGSIVSVDTAPSQAQQGT 283
            :...||.....:.||......||.|:.||........:.  :.:.:|...:  ::..|.:.::.|
Zfish  1031 ITKRRAEIMAEQAFRKLSPPTLSPLKEQEEEEEKEEAVDEEQELEEIEAML--LEEFPPEDEEET 1093

  Fly   284 QIAEDNDVTNASE-----------------TAGTVLARDLAIERMDGGPNGAVTA---------- 321
            :..|.....:|.|                 |:.|.|..|..|.|:      .::|
Zfish  1094 EDEEQETEESAEERLEVEISERFEKDDDNLTSMTDLLSDNQIPRL------VISAGRLPRIVRYQ 1152

  Fly   322 -LKTGTTSADDDSGVVVTQQP--------------KLRQAAG---------------PDES---- 352
             ||......::...:..|.||              |...|.|               |.:|
Zfish  1153 LLKEIKPLMENRDSLFQTCQPISYSLARRLLYCSFKYPSAFGCWDPVKYTEGDLIQPPQDSYHST 1217

  Fly   353 ----------------------------------GSDLPPIIWVIGGPGSNKATLCLKAVGLNPG 383
                                              ...||..:.:||.|.|.|.|:. :|.....|
Zfish  1218 FPVILHQFIYFFASKETRNTFILNPIKYLRQPRPNPSLPIKLAIIGPPKSGKTTVA-QAFAREYG 1281

  Fly   384 WAHISVGRLLRNITDSAPRANTE-SFAVKEALAAGDMAPEKSLNQLLETNLRQLRDRT-GIIVDG 446
            ...:|:|..:|.:.:|  :|.|: :..|:..|..|...|::...|.:|..:..|...| |.::||
Zfish  1282 LTRLSIGDAIRMVLNS--QAKTDLACQVQIHLKQGQTVPDELAIQCVEVAVMNLVCTTRGFVLDG 1344

  Fly   447 YPRNLQQVKYFENKYKQRPPIILLDCSKLQLGRGRIDDTVSSFRRRLELFREQTLPMLKILDTSN 511
            :|....|.:..|:      .||.:...:|||      |||...:|.|   |::        :.:|
Zfish  1345 FPVTKHQAELLES------CIIPMVVVELQL------DTVEVLKRGL---RDR--------EKNN 1386

  Fly   512 RLQIVDGDTDSPSVQREFERLIRNHIQRLLNKTDDIDDSANLGNQMMRNEQTDAILHDLETNVPG 576
            |...|..|:                :|.|           |:.|...|.|.....|| |......
Zfish  1387 RSHQVHHDS----------------LQAL-----------NIRNSCFRQEAEALRLH-LHNQYHN 1423

  Fly   577 AVPTISH 583
            ..|..:|
Zfish  1424 WTPVDAH 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9541	NP_001260273.1	aden_kin_iso1	67..238	CDD:130427	43/259 (17%)
		ADK	70..230	CDD:238713	41/248 (17%)
		aden_kin_iso1	358..521	CDD:130427	43/164 (26%)
		ADK	359..521	CDD:238713	43/163 (26%)
ak9	XP_685909.5	adk	33..280	CDD:273569
		ADK	33..276	CDD:238713
		AAA_17	394..504	CDD:289950
		DUF3508	<717..804	CDD:288841	2/6 (33%)
		Ribosomal_L24e_L24	<775..808	CDD:294589	2/10 (20%)
		NK	816..>983	CDD:302627	24/168 (14%)
		Adk	1258..1445	CDD:223637	54/227 (24%)
		ADK	1258..1432	CDD:238713	54/227 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740