DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9541 and AK7

DIOPT Version :9

Sequence 1:	NP_001260273.1	Gene:	CG9541 / 34220	FlyBaseID:	FBgn0032083	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_006720084.1	Gene:	AK7 / 122481	HGNCID:	20091	Length:	730	Species:	Homo sapiens

Alignment Length:	473	Identity:	90/473 - (19%)
Similarity:	153/473 - (32%)	Gaps:	164/473 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 VLQKQIDYGAKLGHVVLSLAKMELENFFKNVMPVADYFDQSDMLLAVNGERAPTEVYKDFRTA-- 237
            |:...:.|||:.|         .|..|||               :|..||.....|:.|....
Human   211 VVAAGLQYGAEGG---------MLHTFFK---------------MAWLGEIPALPVFGDGTNVIP 251

  Fly   238 ---VLDILSTLENQEAVMNGV------TGMGRGIHDIPGSI--VSVDTAPSQAQQGTQIAEDNDV 291
               |||:...::|   |::.|      ..:...:|.:...:  :|.:|.|.:.|   :|..:|..
Human   252 TIHVLDLAGVIQN---VIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQ---KIPRENAY 310

  Fly   292 TNASETAGTV--LARDLAIERMDGGPNGAVT-ALKTGTTSADDDSGVVVTQQPKLRQAAGPDESG 353
            .....|...:  |..:|.:|.:....|..:. |.:||....      :.|...:.:|:.|
Human   311 LTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVEN------INTILKEYKQSRG----- 364

  Fly   354 SDLPPI-IWVIGGPGSNKATLCLKAVGLNPGWAHISVGRLLRNITDSAPRANTESFAVKEALAAG 417
              |.|| |.::|.|...|:::. |.:.......||.    |:::...| .|..|:......:..|
Human   365 --LMPIKICILGPPAVGKSSIA-KELANYYKLHHIQ----LKDVISEA-IAKLEAIVAPNDVGEG 421

  Fly   418 DMAPEK---------------SLNQLLETNLRQLRDR-----------------TGIIVDGYPRN 450
            :...|:               .:.:.:|.|..||.|:                 .|.|:||:|:.
Human   422 EEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKT 486

  Fly   451 LQQVKYFENKYKQRPP------------------IILLDCSKLQLGRGRI--------------- 482
            ..|.|...|:..:...                  :..||.|. :..:.|:
Human   487 YDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASD-EFLKERVINLPESIVAGTHYSQ 550

  Fly   483 ----------------DDTVSSFRRRLELFREQTLPMLKILDTSNRLQIVD-----------GDT 520
                            |:||.::...||: ....:.:.|:.|..|||.|..           |.|
Human   551 DRFLRALSNYRDINIDDETVFNYFDELEI-HPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLT 614

  Fly   521 DSPSVQRE----FERLIR 534
            |....:.|    .|||.|
Human   615 DEEKAEEERKAAEERLAR 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9541	NP_001260273.1	aden_kin_iso1	67..238	CDD:130427	14/67 (21%)
		ADK	70..230	CDD:238713	12/54 (22%)
		aden_kin_iso1	358..521	CDD:130427	44/255 (17%)
		ADK	359..521	CDD:238713	43/254 (17%)
AK7	XP_006720084.1	WcaG	<147..310	CDD:223528	27/128 (21%)
		NADB_Rossmann	<149..307	CDD:304358	26/125 (21%)
		ADK	369..>548	CDD:238713	30/185 (16%)
		Dpy-30	679..>711	CDD:253069
		GVQW	713..>730	CDD:290611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830