DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18088 and CG6236

DIOPT Version :9

Sequence 1:	NP_001260271.1	Gene:	CG18088 / 34219	FlyBaseID:	FBgn0032082	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_650446.2	Gene:	CG6236 / 41857	FlyBaseID:	FBgn0038318	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	182/729 - (24%)
Similarity:	306/729 - (41%)	Gaps:	147/729 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LALCCFLTIVLFLIYSSNTSSNTNHDLYPPTTRFSRVSVKAEPQKFFVKTSKCHIPYVDPFNDEA 79
            :|.||.:.::|...|..|...:.:..|        ::.:.....:..|...:|..|::...|.:.
  Fly    12 IAACCCVVVLLVTWYVLNVERDLDKSL--------KIEIIERSIRSAVNRGECRHPHLPLDNPDI 68

  Fly    80 MELYKPQTLITCSNETDLISTTYNEIIKRHILHIDDEVAQK----LLNFTD----KDYNCFYREI 136
            |:.|||...|.|....|.:      :.::.|..:..|:|..    :.::||    .||     ::
  Fly    69 MKFYKPVERINCGEGMDWV------MCEKSICFVRPEIASSHEDVICSYTDIIRKSDY-----KV 122

  Fly   137 KYGKIADTYDNLKAKKYFTSGYEVPVHVEGMIVECQTADDPIVVLQK---DAFAFIQH------- 191
            ::|:      :|:.|:.:.               .|.:|...||.:.   :::..:.|
  Fly   123 RFGQ------SLRMKEPYV---------------LQASDFVKVVCRSSSGESWFGMAHGIRDTVP 166

  Fly   192 RPLPKDSIRPRAARKP--------------------SVIMYGIDSLSRINLRRTMPKVFNFL-QG 235
            || |..:..|..|..|                    :|:|:|.|||||....|.:|:.:.:| |.
  Fly   167 RP-PASNFSPNLAVLPPEAVAQAQQQMQDGATAPIYNVLMFGFDSLSRNAFIRKLPRTYEYLTQQ 230

  Fly   236 PGWYEMQGYNKVADNSFPNILAILSGYSASTAKENVCDTDKQGCLDEMPMIWKYFKNASYLTGYA 300
            .|...::|||.|.|.:...::.:|:|::.....|........|.:|..|||||.|....|:|.:.
  Fly   231 LGATVLKGYNIVGDGTPQALVPLLTGFTELELPETRKRLSGAGSVDSYPMIWKDFARLGYMTSFN 295

  Fly   301 EDESNSNHFNYLKPGFSKKPMDYYFRPLL-----RALESEMD-VYRLPEHDYMRYCLGRRIANRY 359
            ||..|...|.|...||..:|:|:|.|...     .|.||:.: :...|:|..|
  Fly   296 EDLPNVGTFTYRMTGFEAQPVDHYLRTYYVQAEHMAAESKPNCIGHQPDHITM------------ 348

  Fly   360 IYDYGLQFTKRFV---HDRPIWGMFWSNHFSHDDPFMPSAMQEKVLGDLIDMHADGQFEEMIMIF 421
                 |::||.|:   .|.|.:...:....|||...:..|..:.|...|:.:......::.|:|.
  Fly   349 -----LEYTKNFMLKYRDAPRFAFSFHGGLSHDSINLVGAADDDVHDWLVALKERSLLDDTILIM 408

  Fly   422 FADHGTRFGDLTYLKEGFLEERLPMMFIYLPPWFRETYPSYVRALELNQHRLSSNFDLHNTLKHI 486
            .||||.||.::....:|..|||||......|..|::.:|...:....|:|.|::.||:|.||||:
  Fly   409 MADHGNRFAEVRATLQGKQEERLPFFSFVFPESFKKRFPQEYKNFLANEHHLTTPFDIHATLKHV 473

  Fly   487 IEIGGTPDG-REL--PKSFDCP-----------TCQSLFYPLPEGRTCSEAGIEEHWCTCEPYKI 537
            |::....|. .|:  ||:...|           ...||..|:|..|:|::|.||.|||.|..:..
  Fly   474 IQLQTAVDQFGEINDPKTETSPPGIRISELARGRAMSLLDPIPSNRSCADAYIEPHWCACLNWLP 538

  Fly   538 ISGQD--WTTPI---AHSVIDRMNEYFVQKNLTSLCSNLTLNYV--------HKTEIKTGLNID- 588
            :...|  :|..|   |.|:::.:|...|::.  ..|:.|.::.|        ||..::...|.|
  Fly   539 LQLNDSRYTGIILKAAQSIVNAINLATVEQR--QYCAPLEIHRVNWALRLQPHKELLQFRTNSDR 601

  Fly   589 -------WHQTLMESETAVYRIKFKVKQNSADFQATVVYHNSTQNAQVNVEKISRTNSYKEDSTC 646
                   ..|||:..|  :|:::.........|:|:|.|...|.:|...:..|||.|.|...:.|
  Fly   602 DGFLADMTGQTLVRDE--MYQLQVVTMPGEGLFEASVAYSLHTFSATTKLTDISRVNKYGNQARC 664

  Fly   647 IDDKLAKL--YCIC 658
            |.|:..:|  ||.|
  Fly   665 IYDRDPELRKYCYC 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18088	NP_001260271.1	DUF229	84..577	CDD:281053	142/567 (25%)
CG18088	NP_001260271.1	ALP_like	207..489	CDD:293745	89/311 (29%)
CG6236	NP_650446.2	DUF229	73..581	CDD:281053	141/559 (25%)
CG6236	NP_650446.2	ALP_like	201..477	CDD:293745	88/292 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910