DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18088 and F15H10.7

DIOPT Version :9

Sequence 1:	NP_001260271.1	Gene:	CG18088 / 34219	FlyBaseID:	FBgn0032082	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_505674.1	Gene:	F15H10.7 / 184555	WormBaseID:	WBGene00008874	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	728	Identity:	174/728 - (23%)
Similarity:	309/728 - (42%)	Gaps:	147/728 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RICSSYSLY-KFLALCCFLTIVLFLIY----SSNTSSNTN-HDLYPPTTRFSRVSVKAEPQKFFV 62
            ||..:||.| .:.:....:.::.|.:|    .:.|..:|: |.||....|.|:
Worm     5 RIFYNYSHYITYYSKVALIFVICFGVYYGLFRTETDFSTHPHFLYLQKLRDSQ------------ 57

  Fly    63 KTSKCHIPYVDPFNDEAMELY-KPQTLITCSNETDLISTTYNEIIKRHILHIDDEVAQKLLNFTD 126
            ..|:|.||..||::...:..| ||..|:..:.:...:.:..|     .||..:.:|.
Worm    58 SKSECVIPDADPWDPSILSYYSKPSPLVCSTMQVQAVKSFNN-----GILTFEPQVI-------- 109

  Fly   127 KDYNCFYREIKYGKIADTYDNLKAKKYFTSGYEVPVHV------------EGMIVECQTADDPIV 179
            |:..|:...|::.:.....|.:         ||.||.:            |...:.|::.:
Worm   110 KNARCYKTGIRHDENVTDLDVI---------YEKPVPLNLTHTSSIKISDEVFQITCESDN---- 161

  Fly   180 VLQKDAFAFIQHRPLPKDS------IRPRAARKPSVIMYGIDSLSRINLRRTMPKVFNFLQGPGW 238
            :|:.:.|.:...:.:||.|      |....:..|||||.|:||:||.|..|.|.|.:.:::..|:
Worm   162 LLKSEIFKYHYTQIVPKSSNIKNKVIEQSTSDFPSVIMIGLDSMSRGNFVRQMQKTYKYMKEAGF 226

  Fly   239 YEMQGYNKVADNSFPNILAILSGYSASTAKENVCDTDKQG--CLDEMPMIWKYFKNASYLTGYAE 301
            .:|:|:.|:.||::.|:||||:|......||...:.::..  ..||...|||.|.:..|.|.:||
Worm   227 IDMEGHMKIHDNTYGNLLAILTGKRGVGVKEFSTEINESWHIAFDEFDFIWKTFSDNGYATLFAE 291

  Fly   302 DESNSNHFNY--LKPGFSKKPMDYYFRPL-------LRALESEMDVY-RLPEHDYMRYCLGRRIA 356
            |..:...|.|  :..||.|:|.|:|.||.       |.:..|....| ..|:|         :|.
Worm   292 DRPDIGTFTYKNMLEGFLKQPTDHYIRPFWISAFWSLISRRSVASCYDSTPQH---------KIQ 347

  Fly   357 NRYIYDYGLQFTKRFVHDRPIWGMFWSNHFSH---------DDPFMPSAMQEKVLGDLIDMHADG 412
            .:|:.::..::.|     :..:..:||...||         ||.|      ||..     .:.:.
Worm   348 LKYLEEFLEKYDK-----KRKFAFWWSQDMSHGFLNLIGKVDDDF------EKFF-----KNNEK 396

  Fly   413 QFEEMIMIFFADHGTRFGDLTYLKEGFLEERLPMMFIYLPPWFRETYPSYVRALELNQHRLSSNF 477
            :.|:.|:|.|:|||.|:..:.....|.:|.|:|...|.:|...::.||..|..|.:|...:::.|
Worm   397 RMEDSIIIVFSDHGHRYDKIRETVIGRIESRMPFHSIRIPDGIKKKYPQIVENLMVNSKLMTTQF 461

  Fly   478 DLHNTLKHII--EIGGTPDGRELPKSFDCPTCQSLFYPLPEGRTCSEAGIEEHWCTC-------- 532
            |::::|:.|.  ::|......:..:|:      |.|.|.|:...|.||||...:|.|
Worm   462 DVNDSLRKIATGKVGEKWTQTDRKRSY------SYFDPFPKRIGCYEAGIPSDFCPCFSEIEIPK 520

  Fly   533 --------EPYKIISGQDWTTPIAHSVIDRMNEYFV-QKNLTS-LCSNLTLNYVHKTEIKTGL-- 585
                    |..:|::.....|       ::..||.. .|.||. :|:.:.:..|..:.::..:
Worm   521 SEAKEAAVELMRIVNDLLENT-------EKTEEYEPDSKELTEYMCTPMEIQNVEFSSVRLPMLS 578

  Fly   586 ---NIDWHQTLMESETAVYRIKFKVKQNSADFQATVVYHNSTQNAQVNVEKISRTNSYKEDSTCI 647
               ::....|.::|.:..|.:..:.|..|.....:.:.||...|...::.::.|.|.|...|.|:
Worm   579 VLKDVKSEDTPLQSFSLQYHVVVRAKAPSNALLESTLEHNLKTNTWSSLGEVERNNKYGNTSFCV 643

  Fly   648 DDKLAKLYCICFS 660
            :|::.|..|.|.|
Worm   644 NDRILKKICHCIS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18088	NP_001260271.1	DUF229	84..577	CDD:281053	134/551 (24%)
CG18088	NP_001260271.1	ALP_like	207..489	CDD:293745	89/304 (29%)
F15H10.7	NP_505674.1	DUF229	79..568	CDD:281053	134/552 (24%)
F15H10.7	NP_505674.1	ALP_like	195..472	CDD:293745	89/301 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770