DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18088 and R03G8.3

DIOPT Version :9

Sequence 1:	NP_001260271.1	Gene:	CG18088 / 34219	FlyBaseID:	FBgn0032082	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_510174.3	Gene:	R03G8.3 / 181437	WormBaseID:	WBGene00010998	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	691	Identity:	152/691 - (21%)
Similarity:	270/691 - (39%)	Gaps:	120/691 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CF---LTIVLFLIYSSNTSSNTNHDLYPPTTRFSRVSVKAEPQKFFVKT-SKCHIPYVDPFNDEA 79
            ||   |.::.|.::|...|......||.|.:  ..:..|....|..|:. .:|.:|..|.::||.
Worm    21 CFAMYLVLLGFTMFSPLLSPQQYLGLYQPIS--GNIPSKVVMNKSEVEPWDQCELPQYDIWDDEI 83

  Fly    80 MELYKPQT--LITCSNE----TDLISTTYNEIIKRHILHIDDEVAQKLLNFTDKDYNCFYREIKY 138
            :.....:.  :..|:..    |.|.:.::..:.|:          .||:        |  |...:
Worm    84 LPYLNMEVNPISNCNKSREPLTFLNNGSWGVVNKK----------TKLI--------C--RARCH 128

  Fly   139 GKIADTYDNLKAKKYFTSGYEVPVHVEGMIVECQTADDPIVVLQKDAFAFIQHR----PLPKDSI 199
            .:.::.| |:.....:|.|   |::.|  :||...||.     :||.:.|:..:    |..:.::
Worm   129 TRKSERY-NVIGNWTYTPG---PINCE--VVEAVCADG-----KKDVYGFLHTQVIATPPKQPTV 182

  Fly   200 RPRAARKPSVIMYGIDSLSRINLRRTMPKVFNFLQGPGWYEMQGY-NKVADNSFPNILAILSGYS 263
            :....:...|.:..:||||....:|::.:..:::.......:..| |||.|||.||..|:..|.|
Worm   183 KVSELKNYDVTVIMLDSLSFTQAKRSLLRTISYMTNHMDAVLFPYINKVGDNSRPNGAALWFGKS 247

  Fly   264 AST------AKENV---------CDTDKQGCLDEMPMIWKYFKNASYLTGYAED--ESNSNHFNY 311
            ...      .:|||         |...|    |....::|.::|..|.|..|||  |...|..|.
Worm   248 LEKLDRSLFEEENVPVDWSHAYMCHVYK----DNETSLFKEYQNYGYKTLMAEDWAEGTLNWPNC 308

  Fly   312 LKPGFSKKPMDYYFRPLLRALESEMDVYRLPEHDY--MRYCLGRRIANRYIYDYGLQFTKRFVHD 374
              .||.|.|:|:..||...|||.......|.:...  .:||   |..:..:.||..||...: .|
Worm   309 --KGFDKPPIDHLMRPFQNALERANHGEPLTKSHLKNQKYC---REDHHTLLDYLSQFINAY-PD 367

  Fly   375 RPIWGMFWSNHFSHD-DPFMPSAMQEKVLGDLIDMHADGQFEEMIMIFFADHGTRFGDLTYLKEG 438
            :..:...|::...|| :...|.:  :|.....:..|.: |.:...:.|..|||.|||::.....|
Worm   368 QNKFRWIWASILGHDSENGFPHS--DKDFHKFLIKHRE-QLDNSFVFFMGDHGLRFGNVRKTFVG 429

  Fly   439 FLEERLPMMFIYLPPWFRETYPSYVRALELNQHRLSSNFDLHNTLKHIIEIGGTPDGRELPKSFD 503
            .|:...|.:.:.:|...|:| ...:..:..|..::.::||...|:..|::.....:..:|
Worm   430 TLDVSNPFLAVSIPKNLRQT-TGLLNVMRENAQKIQTHFDTRATMLDILKYQSASNFTDL----- 488

  Fly   504 CPTCQSLFYPLPEG-----------RTCSEAGIEEHWCTCEPYK--IISGQDWTTPIAHSVIDRM 555
                ..|..|..:|           |.|....|...:|.|:..|  :.:..:....:..:|...:
Worm   489 ----DPLIIPGEKGYSYIRTQPDILRNCRNMPIPMQYCICQFNKTQVSTKSETAKGVGEAVALAV 549

  Fly   556 NEYFVQKNLTSLCSNLTLNYVHKTEIKTGLNIDWHQTLMES--ETAVYRIKFKVKQNSADFQATV 618
            |....:...|..|..:.:::|...       :.:.|....|  .|||..:   .|.:.|.::|.|
Worm   550 NNEIEEGKFTDKCVKMKVDHVVSL-------LQFDQKFKGSMLYTAVVEM---TKPSKAVYKANV 604

  Fly   619 VYHNSTQNAQVNV-EKISRTNSYKEDSTCIDDKLAKLYCIC 658
               ...:|.:|.| ..:.|:|.|...:.||..:..:.||.|
Worm   605 ---KILENGEVKVLGMVERSNKYGSTAYCIGSEHHRPYCYC 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18088	NP_001260271.1	DUF229	84..577	CDD:281053	114/536 (21%)
CG18088	NP_001260271.1	ALP_like	207..489	CDD:293745	78/302 (26%)
R03G8.3	NP_510174.3	DUF229	92..570	CDD:281053	114/531 (21%)
R03G8.3	NP_510174.3	ALP_like	190..480	CDD:293745	78/303 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.900