DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18088 and F10C2.3

DIOPT Version :9

Sequence 1:	NP_001260271.1	Gene:	CG18088 / 34219	FlyBaseID:	FBgn0032082	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_506015.2	Gene:	F10C2.3 / 179650	WormBaseID:	WBGene00008644	Length:	604	Species:	Caenorhabditis elegans

Alignment Length:	674	Identity:	180/674 - (26%)
Similarity:	286/674 - (42%)	Gaps:	97/674 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LRICSSYSLYKFLALCCFLTIVLFLIYSSNTSSNTNHDLYPPTTRFSRVSVKAEPQKFFVKTSKC 67
            ||...::.|: ||....||...||.  ||..|.|..          :|.||..:.|.   .:|||
Worm     2 LRRLGAFVLF-FLCTTVFLFPDLFA--SSTISRNLK----------TRRSVARQKQN---SSSKC 50

  Fly    68 HIPYVDPFNDEAMELYKPQTLITCSNETDLISTTYNEIIKRHILHIDDEVAQKL----LNFTDKD 128
            .:|.:||::...:|    ..|...|..|.|  ..::..::..:..:|:....:|    ::.:...
Worm    51 VVPTLDPWDQSILE----YVLDDGSRPTQL--ACHDAKVQPELTFLDENGVLQLNSTAVSESSLK 109

  Fly   129 YNCFYREIKYGKIADTYDNLKAKKYFTSGYEVPVHVEGMIVECQTADDPIVVLQKDAFAFIQHRP 193
            ..|.||  .|.|:....:.|...::.:....|.:..|.:.|.||.|..|    :...::...::.
Worm   110 VECQYR--TYDKMDGDDEQLNYSEWISFNMSVKIESEFVEVSCQRAWFP----RTKVYSNNHNQI 168

  Fly   194 LPKDSIRPRAARKPSVIMYGIDSLSRINLRRTMPKVFNFLQG-PGWYEMQGYNKVADNSFPNILA 257
            :|....:| .:.|.|||:..:||:|..|.||||.|..:.:.. .|.:...|..|:.||||.|.:.
Worm   169 IPISRSQP-VSDKSSVIVIVLDSVSHSNFRRTMNKTLDVMHSLYGSFIFDGMTKIGDNSFSNAVG 232

  Fly   258 ILSGYSASTAKENVCDTDKQGCLDEMPMIWKYFKNASYLTGYAEDESNSNHFNYLKPGFSKKPMD 322
            ..:|...:|.     ..|..|..|:..:|||:::...|.|.||||....|.||||..||.|||:|
Worm   233 FFAGKWWNTE-----FGDAHGYFDDHDLIWKHYRENGYRTLYAEDYPGFNLFNYLSKGFKKKPVD 292

  Fly   323 YYFRPLLRALESEMDVYRLPEHDYMR-YCLGRRIANRYIYDYGLQFTKRFVHDRPIWGMFWSNHF 386
            :||||..      ::||....|...| .|.|....:....:|..||..:: .|:|.:.:.|....
Worm   293 HYFRPYW------LNVYWTYVHRRSRNLCYGNHRMHNLQLNYLSQFVSKY-KDQPKFAISWLTEL 350

  Fly   387 SHDDPFMPSAMQ-EKVLGDLIDMHADGQFEEMIMIFFADHGTRFGDLTYLKEGFLEERLPMMFIY 450
            .||  ::..... ::.|.:.:..|.: ..|...:...:|||.||.::.....|.||||||...:.
Worm   351 GHD--WLNQVRYGDEDLANFLKKHVE-DLENSYLFIMSDHGHRFDNIRKTSIGRLEERLPFFSVS 412

  Fly   451 LPPWFRETYPSYVRALELNQHRLSSNFDLHNTLKHIIEIGGTPD---GRELPKSFDCPTCQSLFY 512
            ||...|:. ...|..:..|..:|:|.||::.|.:||:.....||   |            :|||.
Worm   413 LPKKLRKD-SKLVDTVRKNSKKLTSFFDVYATFRHILNNSKQPDVMRG------------ESLFL 464

  Fly   513 PLPEGRTCSEAGIEEHWCTCEPYKIISGQDWTTPI---AHSVIDRMNEYFVQKNLTSL-----CS 569
            |:.: |.|..|.|.|.:|.|         |...|:   |::.|..|.|.|.:.....|     |.
Worm   465 PIKD-RNCETAHIPEEFCVC---------DTEVPLNVSANAQIRTMAEDFAKDINQRLDPHPQCV 519

  Fly   570 NLTLNYVHKTEIKTGLNIDWHQTLMESETAVYRIKFKVKQNSADFQATVVYHNSTQNAQVNVEKI 634
            .|.|        |..:::.....:.|..   ||...:|..::|.|:|.::|........| :..|
Worm   520 QLYL--------KNVISVSQVGDVKEQR---YRFTIEVSPSNAIFEALLLYDPFESQTTV-IGDI 572

  Fly   635 SRTNSYKEDSTCIDDKLAKLYCIC 658
            :|.|.|...|.|:.|:..:..|.|
Worm   573 NRINKYGNQSLCVQDQFLRKLCFC 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18088	NP_001260271.1	DUF229	84..577	CDD:281053	137/510 (27%)
CG18088	NP_001260271.1	ALP_like	207..489	CDD:293745	90/284 (32%)
F10C2.3	NP_506015.2	DUF229	110..527	CDD:281053	132/469 (28%)
F10C2.3	NP_506015.2	ALP_like	182..451	CDD:293745	90/284 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970