DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18088 and Y73F8A.35

DIOPT Version :9

Sequence 1:	NP_001260271.1	Gene:	CG18088 / 34219	FlyBaseID:	FBgn0032082	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001255870.1	Gene:	Y73F8A.35 / 178438	WormBaseID:	WBGene00013539	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	159/752 - (21%)
Similarity:	267/752 - (35%)	Gaps:	222/752 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KFLALCCFLTIVLFLIYSSNTSSNTNHDLYPPTTRFSRVSVKAEPQKFFVKT------------- 64
            :.|.:.||:|.:..|.::.         |.|..|....|.|.   |..|.|.
Worm    12 RLLIITCFITYLGLLAFTL---------LVPAPTSIQYVGVY---QPIFGKLEENGSLVVKGDLW 64

  Fly    65 SKCHIPYVDPFNDEAME-LYKPQTLITCSN----ETDLISTTYNEIIKRHILHIDDEVAQKLLNF 124
            .:|.:|..:.:||:.:: |...:|.||..|    .|.||:.::|.:                 |.
Worm    65 DRCDLPDYEIWNDDILKYLNMDETPITKCNIAPPLTYLINGSWNAV-----------------NA 112

  Fly   125 T---DKDYNCFYREIKYGKIADTYDNLKAKKYFTSGYEVPVHVEGMIVECQTADDPIVVLQKD-- 184
            :   |....|.:|:       |...|.......|.|   ||..|.:...|          .||
Worm   113 SAGYDCKTRCHWRK-------DDRTNFIGNWNSTPG---PVDCEFLEAIC----------LKDNL 157

  Fly   185 -AFAFIQHRPLPKDSIRPRA----ARKPSVIMYGIDSLSRINLRRTMPKVFNFLQGPGWYEMQGY 244
             .:.::..:.:|...|.|:.    .::..|.:..:|||:.....|::|:..:::.......:..|
Worm   158 KVYGYMHSQIIPTPPITPKVDVSKLQQYDVTVILLDSLAHAQALRSLPRAISYMTSHMSAVVFPY 222

  Fly   245 -NKVADNSFPNILAILSGYSASTAKENVCD--------TDKQGC---LDEMPMIWKYFKNASYLT 297
             |||.:||..|.:.:..|.|.....:::.|        |.:..|   .|....|:..|::..|.|
Worm   223 VNKVGENSRSNGVPLWFGKSLEKLDKSLFDEEDVTVDWTHEYMCNEFKDNETSIFNEFRDYGYKT 287

  Fly   298 GYAED--ESNSNHFNYLKPGFSKKPMDYYFRPLLRALESEMDVYRLPEHDYMRYCLGRRIANRYI 360
            ..|||  |...|..|.  .||...|:|:|.||...|||.       |.|       |..|...::
Worm   288 LLAEDWAEGTLNFPNC--KGFDNPPIDHYMRPFQNALER-------PHH-------GEFITRNHL 336

  Fly   361 ---------YDYGLQFTKRFVHDRP-----IWGMFWSNHFSHD--DPFMPSAMQEKVLGDLIDMH 409
                     ::..|::..:|::..|     .|  .|::|..||  :.|               .|
Worm   337 SPGNLTREHHNTLLEYLSKFMNAYPNEKKFSW--IWASHLGHDSMNGF---------------SH 384

  Fly   410 ADGQF-----------EEMIMIFFADHGTRFGDLTYLKEGFLEERLPMMFIYLPPWFRETYPSYV 463
            ||..|           :...:|...|||.|||.......|.||...|.:.|.:|...|:| ...:
Worm   385 ADNDFYNFLVKHREKLDNSFVILMGDHGPRFGANRKTVSGELEVHNPFLGISIPKALRKT-TEIL 448

  Fly   464 RALELNQHRLSSNFDLHNT----LKH----------IIEIGGTPDGRELPKSFDCPTCQSLFYPL 514
            ..::.|..:|.:::|...|    ||:          |::|.|......:.|..|.|
Worm   449 SLMKGNAKKLQTHYDTRATILDILKYQSTTNFLDTEILKIPGEKGFSFIRKQPDTP--------- 504

  Fly   515 PEGRTCSEAGIEEHWCTCEPYKIISGQDWTTPIAHSVIDRMNEYFVQKNLTSLCSNLTLNYVHKT 579
               |.|....|...:|.|:..:       ||...||.:    .:.:.|.||:..:         |
Worm   505 ---RNCKTMPIPIQYCLCKFNR-------TTESIHSDL----AHSMAKALTAAVN---------T 546

  Fly   580 EIKTGLNIDWHQTLMESETAVYRIKFKVKQNSADFQATVVY-----HNSTQNA--QVNVEKIS-- 635
            |::.| .:......||     |.|...:.:....|:.:::|     .....||  :.|::.:|
Worm   547 ELENG-KLQSRCIKME-----YSIILSLDRLDEKFRGSILYTIVVEMKKPSNAWFKANIKMLSTG 605

  Fly   636 ---------RTNSYKEDSTCIDDKLAKLYCICFSDLH 663
                     |.|.|.:.:.||..:..:.||.|.:.::
Worm   606 ELKVLGIIERVNEYGQTAHCIKSEYHRPYCFCRNQIN 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18088	NP_001260271.1	DUF229	84..577	CDD:281053	120/561 (21%)
CG18088	NP_001260271.1	ALP_like	207..489	CDD:293745	78/336 (23%)
Y73F8A.35	NP_001255870.1	DUF229	89..557	CDD:281053	122/571 (21%)
Y73F8A.35	NP_001255870.1	ALP_like	185..475	CDD:293745	77/323 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940