DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32984 and Y41E3.1

DIOPT Version :9

Sequence 1:	NP_788014.2	Gene:	CG32984 / 34218	FlyBaseID:	FBgn0052984	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001041024.1	Gene:	Y41E3.1 / 178413	WormBaseID:	WBGene00012762	Length:	682	Species:	Caenorhabditis elegans

Alignment Length:	721	Identity:	182/721 - (25%)
Similarity:	297/721 - (41%)	Gaps:	149/721 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LCIFILFLLIVWKITSYGVNDVLTIKY-------------------------------NENQKRF 51
            ||:.:.|:|...:|   |.:||..::.                               :|.....
Worm    17 LCVSVYFVLSTLRI---GYDDVSRLEQSRAERYQEIDEIPVKVRTVHSDRDRHKGEDSSEKHAET 78

  Fly    52 YVNSSNCQMAYVEPFNAE---FTKLYTPKNFTRCSNQSDLVTVHFDSILKQYVLHVDEEVLHKLS 113
            .:.|..|.:..:|...:|   |.|.:.|   ..|..:        :||...:|. :::|.:.:.:
Worm    79 ALQSQKCNIPKLEINGSEVINFFKTHAP---LECQKK--------NSIEDNWVF-INDEAIIRFT 131

  Fly   114 QSKSNKFACFYQNITYGQSADHYDRMGKKTKFTHDYVVPLNVQGMLVECRSGDEKRILQEDAFSF 178
            :.:: |..|   .|.|....|  |...|       |..|       ||...||..........|.
Worm   132 EKRA-KAKC---KIQYFSRVD--DNNNK-------YEEP-------VEVLDGDRMNGSDYATISC 176

  Fly   179 VQ-YQK---------TSPNL------------DIDRKA-SVIMYGIDTVSRTNLRRLMPVVFGFL 220
            :| :||         ..|.:            |.::|. :|...|.|::|:.:.||.:|....||
Worm   177 IQGFQKWKSILWDVNDEPEIHERARKMRKEQADPEKKPYNVYFLGFDSLSQMSFRRKLPQTVKFL 241

  Fly   221 KSP-GWYEMMGYNKVADNTYPNIFSILTGYS----PNSAK-----NQICDTTQPGCLDKIPFIWK 275
            :.. |...:.|||.|.|.|......|||..:    |.:.|     |.:.|.        .|||||
Worm   242 EETLGSVVLNGYNIVGDGTPQAFIPILTAQTETELPLTRKRYKNANYVDDV--------YPFIWK 298

  Fly   276 DMKKNGYLTAYAEDTVFSNIFNYMKPGFLSRPTDYYFRPLLDALEKETIKLYCPGCKMVYCLGRR 340
            :....||:|.||||......|.|...||..:|||:|.|.|.:.:||...:         .|:|..
Worm   299 NYSDKGYVTMYAEDAFSIGTFTYRLKGFRQQPTDHYTRTLFEEVEKLNDR---------NCIGSI 354

  Fly   341 LANSYIFDYCRQFMQRYVADRPIWGFFWSNHISHDDFSMLSAMQHKIVGDLLNFEKDGSFEHTIM 405
            ..:.......||||::| .|.|.:.....:.:||||.:::......:...|.:...:|.|:.:::
Worm   355 PLHRMWLQNGRQFMKKY-EDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVV 418

  Fly   406 IFFSDHGSRFGPLMRTRESFLEERQPIMFIYLPPWFR--EKYPRYVEALAQNQNRLSSNFDIYNT 468
            |..:|||.||..|..|.:..||||.|...|.||...|  ||..:..:.|.:|..:|:|.|||:.:
Worm   419 IVMADHGHRFAKLRDTHQGQLEERMPFFSISLPKQLRNTEKGRKMEQNLRENAEKLTSPFDIHAS 483

  Fly   469 LKHIINIEGLVE-DTKWSYDCPQCQSL--FYELPESRSCSEAAIPEAYCTCHNYEEVQ---EDHG 527
            |..|:|:..|.| :.....|....:||  |..:|..|:||:|.|...:|||.::::..   ||..
Worm   484 LMDILNLSELGENELNRMQDASSKRSLSVFKPIPVDRTCSQAGIEPHWCTCLSWKDAMDTGEDRK 548

  Fly   528 -TWRMAELVVDRINQFLQYHNLQNLCSSLTL-KLVNITEV----------RITESDEHV-----S 575
             |.|:|..||..||:.:...  ::||:.|:| |:::..::          .:.::|..|     |
Worm   549 LTRRIANAVVREINKEIVAE--KDLCAPLSLAKIIDAKKLLPDKGLLAYKNVKDADGFVPDLSGS 611

  Fly   576 LGKGLRHYHTKFQVHQNLAEFFATVLYDRKTEELQINVELISRINIYRPDASCLDDNIQKL--FC 638
            ......||..|.|.....|.:..|:.||...:|::::...:|.:|.:.....|:.|....|  ||
Worm   612 TKAAFAHYQLKLQTTPGEAIYEVTLFYDIVRDEVKLDFGSMSHVNKFGDTPHCIIDKNYYLATFC 676

  Fly   639 ICLSKL 644
            :|..::
Worm   677 VCYDRV 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32984	NP_788014.2	DUF229	75..561	CDD:308570	147/528 (28%)
Y41E3.1	NP_001041024.1	DUF229	78..581	CDD:281053	153/554 (28%)
Y41E3.1	NP_001041024.1	ALP_like	215..491	CDD:293745	92/293 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910