DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9525 and CG11630

DIOPT Version :9

Sequence 1:	NP_609260.1	Gene:	CG9525 / 34217	FlyBaseID:	FBgn0032080	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_610124.1	Gene:	CG11630 / 35429	FlyBaseID:	FBgn0032964	Length:	631	Species:	Drosophila melanogaster

Alignment Length:	626	Identity:	156/626 - (24%)
Similarity:	276/626 - (44%)	Gaps:	83/626 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 IKKQHTICSKDESLINLRFDEKSHQYLLYV-NDHVAQLKLRSMKK----KSPNLIGY-NCSYREL 117
            |.::|.:..|      ...|.|..:.|..| |::......|.:::    .:.||..: ||:|..|
  Fly    32 IFEEHHLVEK------YSVDTKGCRMLTMVPNEYDVMFLWRGLRRDFCASNLNLTSFSNCTYNYL 90

  Fly   118 K-RLNRD-----YIVDAPVVYVC--YLTDRSLKFEDQFLYSLGEEVKFWNGYIVPPSVEGMRATC 174
            : .:|.:     :.|:....:.|  |..:|...|::::|||...|:.......:.|..:.:||.|
  Fly    91 RTEVNMELAKARFGVETLESFKCMYYAMERHTDFDNRYLYSREFELLTDGNNTIEPHADIIRAEC 155

  Fly   175 RNELAEDLQSDTFVLVQPPKTYAPLISWHR----IP-----------NVLLIGFDGISQINFRRN 224
            ... |..:.:.....|.|..      .|.|    :|           :||::|.|.|||::|.|:
  Fly   156 FIN-ATSIYNGVHFYVHPTD------EWLRTAQGLPPLKLASDVGSLSVLIVGLDSISQMHFHRS 213

  Fly   225 FPLVFNQLKMQDWFRMDGYTGIGENTQSNLMASLTGYSPHTLMNLKCDSSVIGCLKTVPLIWKHF 289
            .....|.|.......:.|:..:||:...:||..|:|.|...|.::   ||.:..|.:.|.|||.|
  Fly   214 MARTANFLLSLPHVELKGFNRLGEDGFDSLMPLLSGLSGQELKDV---SSNLSSLDSCPFIWKVF 275

  Fly   290 KKKGFITAYGEGISNLFDSEKY--GIFEGTIDFYARHKNLQSCIDRR--------FNIKHNYD-Y 343
            :|.|:.|..||  .|: |...:  |..:...|||.|...|:..:..|        .|.|.||. .
  Fly   276 QKAGYETGLGE--DNI-DKSLFVKGFRKPPTDFYLRPALLEMWLKTRTDGLFGTHCNEKDNYAMV 337

  Fly   344 CEEFLKR---HANTNRPFFGVFFGNGITNRSYDNARIQTELLDKVKKFKKMGILTQSIVVLFS-Y 404
            ..|||.:   |..::|.|..:::..||.:......::....|...|...:.|:|..:::::.| :
  Fly   338 LREFLFKMLPHHTSHRFFTFLWWTQGIDHLFNYGRKLDQPFLKMFKAIGRSGLLKNTVLLVVSNH 402

  Fly   405 PVSSVKEKKT--NFSQEDLPILYIWLPPWFKAFRPEIVQALRINSKRLTSPYDLHLTLQHL---- 463
            .::..:..||  ...:|..|:..:..|.|.:...|:.:..|:.|::||.:.:|||.|||:|
  Fly   403 GLNKGRFYKTVQGKVEESQPLAILCYPRWLEERYPQAIGNLKSNNRRLVTAFDLHATLQNLPNLT 467

  Fly   464 -LELGERWPRAVDKLV---DCPTCQTLFAPVPENRTCSDAGIGESQCPCDSYKLLSSNQMKQLSV 524
             ||..:...|.||...   |.|...:||.|:|::|.|..|.|..:.|.|...:.:|::.......
  Fly   468 SLEDEQLQQRRVDLWAMGKDIPRGISLFLPIPDHRDCFLAAIPTANCLCQQPRNVSTSDGYVQRA 532

  Fly   525 GKQIVRSINEFLNHHNLHELCHNLTLKSVKMVLQRKDRKLSS--GSTYRAYFSANPNNAEFSTTI 587
            .:.|:|::|:.::.|.  ..|..|.|.  :::...|.|:::.  .|.:|....|.|...:|...:
  Fly   533 ARLIIRNLNKMIHTHT--PPCKTLYLD--RVLTADKWRRIADEHQSEFRVRLIATPGEGQFEGIV 593

  Fly   588 RYANNRQELEYINVESINRLNNYQNDSSCMRRLRGRKFCIC 628
            ||...:..::    ..|:|:|:|:|.|.|:|......:|.|
  Fly   594 RYTGYKLAVD----GHISRVNDYRNGSQCIRNYLIEMYCFC 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9525	NP_609260.1	DUF229	66..554	CDD:281053	135/541 (25%)
CG9525	NP_609260.1	ALP_like	206..466	CDD:293745	79/292 (27%)
CG11630	NP_610124.1	DUF229	66..560	CDD:281053	129/510 (25%)
CG11630	NP_610124.1	ALP_like	195..467	CDD:293745	77/277 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31599at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850