DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1GalTA and B3GLCT

DIOPT Version :9

Sequence 1:	NP_609258.1	Gene:	C1GalTA / 34215	FlyBaseID:	FBgn0032078	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_919299.3	Gene:	B3GLCT / 145173	HGNCID:	20207	Length:	498	Species:	Homo sapiens

Alignment Length:	274	Identity:	62/274 - (22%)
Similarity:	100/274 - (36%)	Gaps:	68/274 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 HQKKARHVKRTWGKRCNKLIFMSSAKDDELDAVALPVGEGRNNLWGKTKEAYKYIYEHHINDAD- 175
            |..:...||:||..:.:.:.:.|...::.:..|.|.:........|||..    |.|..:|.:.
Human   280 HGDRIPIVKQTWESQASLIEYYSDYTENSIPTVDLGIPNTDRGHCGKTFA----ILERFLNRSQD 340

  Fly   176 ---WFLKADDDTYTIVENMRYMLYPYSPETPVYFGCKFKPYVKQG---YMSGGAGYVLSREAVRR 234
               |.:..||||...:..::::|..|....||:.|.::...:..|   |::||.|.|.|||||||
Human   341 KTAWLVIVDDDTLISISRLQHLLSCYDSGEPVFLGERYGYGLGTGGYSYITGGGGMVFSREAVRR 405

  Fly   235 FVVEALPNPKLCKS-DNSGAEDVEIGKCLQNVNVLAGDSRDSNGRGRFFPFVPEHHLIPSHTDKK 298
            .:...      |:. .|...:|:.:|.|.             :|.|     :|..|
Human   406 LLASK------CRCYSNDAPDDMVLGMCF-------------SGLG-----IPVTH--------- 437

  Fly   299 FWYWQYIFYKTDEGLDCCSDNAISFHYVSPNQMYVLDYLIYHLRPYGIINTPDALPNKLAVGELM 363
                                 :..||...|.. |..||| .|..|.......:..|.|:....|.
Human   438 ---------------------SPLFHQARPVD-YPKDYL-SHQVPISFHKHWNIDPVKVYFTWLA 479

  Fly   364 PEIKEQATESTSDG 377
            |..:::|.:.|..|
Human   480 PSDEDKARQETQKG 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1GalTA	NP_609258.1	Galactosyl_T	119..>265	CDD:304462	41/153 (27%)
B3GLCT	NP_919299.3	Galactosyl_T	264..467	CDD:304462	55/246 (22%)
B3GLCT	NP_919299.3	Prevents secretion from ER	495..498
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810