DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp29Fa and CD63

DIOPT Version :9

Sequence 1:	NP_001162915.1	Gene:	Tsp29Fa / 34211	FlyBaseID:	FBgn0032074	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_001244318.1	Gene:	CD63 / 967	HGNCID:	1692	Length:	238	Species:	Homo sapiens

Alignment Length:	237	Identity:	76/237 - (32%)
Similarity:	127/237 - (53%)	Gaps:	12/237 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GSANAVKYTLFGFNLIFLITGIILIAVGAGVGAVYTGYKLFLAGKFFSIPTFLIVIGSFIIIISF 70
            |....||:.|:...|.|....:.|||||.|...|.:...:..|.....:|..:|.:|.|:.:::|
Human     5 GGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAF 69

  Fly    71 FGCWGALKENYCLVLSFSVMLAIIFILELAAGISGYVLRNDASDLIKTSLTYSLNEYNSINPNAT 135
            .||.||.||||||:::|::.|::|.::|:||.|:|||.|:........:....:..|.  ..|.|
Human    70 VGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYP--KNNHT 132

  Fly   136 TKLWDDIQDEFECCGVTSYNDW--ITAFPNGDLPISCC-NVHVGAVGTFTCNNAQSSVADRHKVG 197
            ..:.|.:|.:|:|||..:|.||  |.:.....:|.||| ||.||....|.    :.::   ||.|
Human   133 ASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFN----EKAI---HKEG 190

  Fly   198 CLDGFSGYISAHAVSLGAAGVVIAILQFFGVIFACYIAREIK 239
            |::...|::..:.:.:.||.:.||.::..|::|||.:.:.|:
Human   191 CVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIR 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp29Fa	NP_001162915.1	Tetraspannin	11..238	CDD:278750	74/229 (32%)
Tsp29Fa	NP_001162915.1	tetraspanin_LEL	106..210	CDD:239401	30/106 (28%)
CD63	NP_001244318.1	Tetraspannin	10..227	CDD:395265	74/225 (33%)
		CD63_LEL	105..203	CDD:239419	30/106 (28%)
		Lysosomal targeting motif. /evidence=ECO:0000250\|UniProtKB:P41731	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4978
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37526
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4509
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005733
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106877
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4418
SonicParanoid	1	1.000	-	-		X3621
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.790