DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and AMS1

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_011359.1	Gene:	AMS1 / 852721	SGDID:	S000003124	Length:	1083	Species:	Saccharomyces cerevisiae

Alignment Length:	1066	Identity:	188/1066 - (17%)
Similarity:	351/1066 - (32%)	Gaps:	374/1066 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 MINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAK 101
            :.|::.:.:.|.|..||.   .:....|..::....|..:      :.:.|..:|:..:...| |
Yeast   288 LTNVYGIGNCHIDTAWLW---PFAETRRKIVRSWSSQCTL------MDRFPEYKFVASQAQQF-K 342

  Fly   102 WWAE-QSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPR 165
            |..| ..|...:|:...:.:.:....||.|..||....:.:|:..||..|.:|....||  .:.:
Yeast   343 WLLEDHPEFFNKVLIPKIQQSQFFAVGGTWVENDTNIPSGESLARQFFFGQRFFLKHFG--LKSK 405

  Fly   166 IGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDASDSLSNDEI-FTGL 229
            |.|..|.||:|.:...:....|.| :|               |..::.|:..:|..:... :.|:
Yeast   406 IFWLPDTFGYSSQMPQLCRLSGID-KF---------------LTQKLSWNNINSFPHSTFNWAGI 454

  Fly   230 ----LYRHYSAPPG--YCFDVHCGDDPIIDTKSYDNNVKSRVDDFLSYVTSVAQHYRSNHIMIPM 288
                |..|  .|||  |..|.|.||  ::.|...:               ...::|.|..::...
Yeast   455 DGSQLLTH--MPPGNTYTADSHFGD--VLRTAKQN---------------KTPEYYGSGLMLYGK 500

  Fly   289 GDDFQYEDAQVNFKNMDKL--IKYVNERQAE-------GSTFNLFYSTPACYLNSLHEGLQTWPN 344
            ||.......::    :.|:  |:.:|.|...       |.|.:.||.......|..|: |.||..
Yeast   501 GDGGGGPTEEM----LQKMRRIRSMNNRNGNVIPKLQVGITVDEFYDDILKRTNQGHD-LPTWSG 560

  Fly   345 KTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGN---HILQ-VAKQLSVFAELNTKQQKEDLEYL 405
            :.  :|       .:..|.:||:...|:..|...   |.|: :|.:.||....:.|...:.:..|
Yeast   561 EL--YF-------EFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLYPDSYKYPSKQINEL 616

  Fly   406 REIMGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNTARDGLRKLTNLPNGEFESCLQLNISE 470
            .|.:.:.|.||.:.|                                         ||:::
Yeast   617 WENVLLCQFHDVLPG-----------------------------------------SCIEM---- 636

  Fly   471 CAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNN 535
                                                        |...|.||:.
Yeast   637 --------------------------------------------VYKYEAVPML----------- 646

  Fly   536 DTQHELVFKAS--VDKIANYYIKKVASQETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNA 598
               |.:|.:.:  :||... :::..:..:...:...|.||....:||.:|.        .|..::
Yeast   647 ---HNVVKECTSLIDKTVQ-FLQSQSKADLVEMRTLTWSKPEKVSEECSLN--------GSYTSS 699

  Fly   599 TETFDDDEGETVVQTSQVKLVIDNKTGLLKTV--EMNGVSENIDQSYG----------VY----- 646
            ...:||   ..|:...::|::|..|||::.::  |..|| |.:|..:|          :|
Yeast   700 VTGYDD---YIVLANGKLKVIICKKTGVITSITDETLGV-EYLDTEHGRNKLGANQFVIYDDKPL 760

  Fly   647 --RTYDSGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIY-----EGKNL 704
              :.:|:..|...||                              :|:::..::.     :.|..
Yeast   761 GWQAWDTELYSVNQY------------------------------KYVTKPKKVQVSCNTKEKCA 795

  Fly   705 VEIEWQVGPIEREEEFGREVVIIFNSTIASDG------VSYTDSNGREMIKRVKDQ-----RETF 758
            ||:.:|:     .|:...:.||..|:|..:|.      :|.|..|.....|.:|.:     |..|
Yeast   796 VEVIFQI-----SEKCKIKSVISLNATAVTDAKLSKVDISTTVENWDARNKFLKVEFPVNIRNDF 855

  Fly   759 TP-----GLDRQPTAANYYPVTSRIA-----------LQDSKKRIAVLNDRAQGGASMLNGQLEL 807
            ..     |:.::||   :|..:..:|           ..:..|.:::|||...|.::
Yeast   856 ASYETQFGITKRPT---HYNTSWDVAKFEVCHHKFADYSEYSKGVSILNDCKYGFST-------- 909

  Fly   808 MLHRRLVRDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAEREAEKEIHLPFWKFFSKN 872
              |..|:|                        :.|:.||.    |.:..|:...|...:..:...
Yeast   910 --HGNLMR------------------------LSLLRSPK----APDAHADMGTHEIKYAIYPHR 944

  Fly   873 TGSTTAAAKSVPSFN-----DFPKSV-----HLLTLEPFNDDEVLLRVENFLDHTEGQVV--SFN 925
            ...::...|....||     ..||.:     .::::.  .|:.|:|  .|.....:...|  :::
Yeast   945 GALSSDTVKLAHEFNYCFKYKLPKDIGMNFDDIISIS--GDENVIL--SNIKRGEDDSAVKSNYS 1005

  Fly   926 IRP---------IFDYLNGVEIR--ETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPL 979
            :.|         :::.|.|....  .|||       ::||.        :|.|.:|  ...:|.|
Yeast  1006 LNPRDEQSIVVRVYESLGGESFASLNTTL-------NLKRI--------EKVDNLE--MKVYKSL 1053

  Fly   980 AA---EQSQEASEFSVTLHPMQIRTF 1002
            .|   |.:...:...:.|.|.:|.:|
Yeast  1054 TATRDESNHAINRIPIKLRPFEIASF 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	57/283 (20%)
		Alpha-mann_mid	359..434	CDD:286360	17/78 (22%)
		Glyco_hydro_38C	482..1002	CDD:285047	99/598 (17%)
AMS1	NP_011359.1	AMS1	44..1083	CDD:223460	188/1066 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840