DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and man2b1

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001072469.1	Gene:	man2b1 / 779924	XenbaseID:	XB-GENE-958698	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	1026	Identity:	415/1026 - (40%)
Similarity:	587/1026 - (57%)	Gaps:	78/1026 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVLFVALLAISVRPSE-EACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHA 70
            ::|.:.||..:.|..: |.||.::||:.....:|:|::||:|:|||||||||||:||..::||||
Frog     7 LLLPLLLLGAAGRLKQAEGCGEQSCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHA 71

  Fly    71 GVQYIIDTVIAELIKDPARRFIQVETSFFAKWWAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDE 135
            |||||:|:|:::|:.||::|||.||::||.:||.:|.|..::.|.:||.||||||..|.||||||
Frog    72 GVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMNDE 136

  Fly   136 AAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRD 200
            ||.:|.|:|||.||||:||..|||.|.|||:.|.|||||||||||.:||||||||.||.|:|::|
Frog   137 AATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDYQD 201

  Fly   201 KNDRIDNLGMEMIWDASDSLSND--EIFTGLLYRHYSAPPGYCFDVHCGDDPIIDTKSY-DNNVK 262
            |.:|.....|||:|.|||.:|..  ::|||:|...|:.|.|:|:|..|.|.||||..|. |.|..
Frog   202 KANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNAD 266

  Fly   263 SRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVNERQAEGSTFNLFYST 327
            ..|..||...|..||.|.|:||::.||.|||||:|.:.|||||:|||.||.:|..||..|:||||
Frog   267 VIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFYST 331

  Fly   328 PACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSVFAE 392
            |:|||.|||....|||.|..|||||....:.:|||||||||..|.:||..|:.|||..|:...:.
Frog   332 PSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEALSG 396

  Fly   393 L---NTKQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNTARDGLRKLTN 454
            |   |....:.....:|..|||.|||||:|||.||||::||...|.:..........:.|..||.
Frog   397 LEARNGPYGQSSSTVMRRAMGVAQHHDAVTGTAKQHVNNDYSLRLSEGWDSCQVVISNSLSSLTG 461

  Fly   455 LPNGEFESCLQLNISECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASE 519
            ... .|..|..||||.|..| :.|:|..|.|||||..:.|..||:||....|:|.......|.||
Frog   462 TKE-NFAFCNLLNISVCHVT-ETANNFKVYLYNPLGRSVTWTVRLPVNGHAYKVIGPNDETVPSE 524

  Fly   520 VVPVAWQVLALEFRNNDTQHELVFKASVDKIANYYIKKVASQETKNVAAHTKSKRSIKAEEANLE 584
            ||.|:....||.|:....:.||:|:..:..:              ..::.|..|         |.
Frog   525 VVDVSDFTKALRFQQGGAERELIFQGQIPAV--------------GFSSFTVGK---------LS 566

  Fly   585 VPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTVE--MNGVSENIDQSYGVYR 647
            :|.||    .:|........|:    :|....::..|.:|||:..:.  ...:|..:.||:..|.
Frog   567 LPDRF----VIKGKRGKKQPDK----IQNQYYRVDFDPETGLISGIHNLEKKISLPLKQSFYWYN 623

  Fly   648 --------TYDSGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIYEGKNL 704
                    :..||||:||. :.:|.:...:.|...:...:||:||||.||.:.|||:|:|..:..
Frog   624 ASVGNEESSQPSGAYIFRP-NNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQVVRLYRDQRY 687

  Fly   705 VEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAA 769
            :|:||.|||:...:|:|:||:.:..:.:.:|||.|||||||:::||.:|.|||:... ..:|.|.
Frog   688 IELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLN-QTEPIAG 751

  Fly   770 NYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLVRDDGYGVGEALNEE-KYGQP 833
            |||||.|||.::....::.||.||:|||:|:.:|.||||:||||:|||..||||.|.|. ..|:.
Frog   752 NYYPVNSRIYIKGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEG 816

  Fly   834 MIARGKVYLILSPSDESTAAEREAEKEIHLPFWKFFSKNTG-----STTAAAKSVPSFNDFPKSV 893
            ::.||:..|:|..:||:....|....:.::......|...|     |.|...|......:.|::.
Frog   817 IVVRGRHLLLLDHADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNG 881

  Fly   894 HLLTLEPFNDDEVLLRVENFLDHTE----GQVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKR 954
            ||||......|::|||:|:.....|    .|.::.|:..:|..::.....||||..|:..|.:||
Frog   882 HLLTFAMHAADKILLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKR 946

  Fly   955 FKFHHDSSGQKPDAVEYFTSAHKPLAAE--QSQEASEFSVTLHPMQIRTFI 1003
                          :::.|....||..:  ::......::||.||:||||:
Frog   947 --------------LQWRTRTGSPLQMDSPRAPVVDPSNITLSPMEIRTFL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	158/276 (57%)
		Alpha-mann_mid	359..434	CDD:286360	37/77 (48%)
		Glyco_hydro_38C	482..1002	CDD:285047	169/541 (31%)
man2b1	NP_001072469.1	PLN02701	39..987	CDD:178304	406/994 (41%)
man2b1	NP_001072469.1	GH38N_AMII_LAM_like	39..317	CDD:212121	159/277 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm47730
Panther	1	1.100	-	-	O	PTHR11607
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.110