DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and MAN2B1

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_005259970.1	Gene:	MAN2B1 / 4125	HGNCID:	6826	Length:	1012	Species:	Homo sapiens

Alignment Length:	1049	Identity:	417/1049 - (39%)
Similarity:	591/1049 - (56%)	Gaps:	122/1049 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCGIVLFVALLAISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQ 68
            ||   .|:.|||.:   ...|.|||.||..:.||:|:|::||:||||||||||||||||.:::||
Human    35 LC---FFLLLLAAA---GARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQ 93

  Fly    69 HAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWWAEQSETAKQVVRKLVNEGRLEFTGGAWSMN 133
            |||||||:|:||:.|:.||.||||.||.:||::||.:|:...::|||.||.:|||||..|.|.||
Human    94 HAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMN 158

  Fly   134 DEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFARMDH 198
            ||||.:|.:::||.||||:||:||||:..|||:.|.||||||||||||:|||||:||.||.|:|:
Human   159 DEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDY 223

  Fly   199 RDKNDRIDNLGMEMIWDASDSLS--NDEIFTGLLYRHYSAPPGYCFDVHCGDDPII-DTKSYDNN 260
            :||..|:..|.||.:|.||.||.  ..::|||:|...|:.|...|:||.|.|.|:: |.:|.:.|
Human   224 QDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYN 288

  Fly   261 VKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVN-ERQAEGSTFNLF 324
            .|..||.||:..|:..::||:||.::.||.|||||:|.:.|||:||||:.|| ::||:||:.::.
Human   289 AKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQQAKGSSVHVL 353

  Fly   325 YSTPACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSV 389
            ||||||||..|::...||..|..|||||....:.:|||||:|||..||:||...:.|||..||..
Human   354 YSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEA 418

  Fly   390 FAELNTK---QQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRIL------YDAILGGVNTA 445
            ...|...   ....|...|.|.|.|:|||||::||.:|||::||.|.|      .:.:|.
Human   419 LVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLS----- 478

  Fly   446 RDGLRKLTNLPNGEFESCLQLNISECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTD 510
             :.|.:|....: .|..|.|||||.|..:: .|....|.:||||.......||:||....:.|.|
Human   479 -NALARLRGFKD-HFTFCQQLNISICPLSQ-TAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKD 540

  Fly   511 EKGRVVASEVVPVAWQVLALEFRNNDTQ-H--ELVFKASVDKIANYYIKKVASQETKNVAAHTKS 572
            ..||.|.|:||         .|.::|:| |  ||:|.||:..:         ...|.:||...:.
Human   541 PNGRTVPSDVV---------IFPSSDSQAHPPELLFSASLPAL---------GFSTYSVAQVPRW 587

  Fly   573 KRSIKAEEANLEVPKR-FKKVHSLKN--ATETFDDDEG---ETVVQTSQVKLVI----------- 620
            |...:|.:   .:|:| :....:::|  ...|||.|.|   |.:....|:.|.:
Human   588 KPQARAPQ---PIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASI 649

  Fly   621 -DNKTGLLKTVEMNGVSENIDQSYGVYRTYDSGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEV 684
             ||::               ||:        ||||:||...|....|. ...:..:....||:||
Human   650 GDNES---------------DQA--------SGAYIFRPNQQKPLPVS-RWAQIHLVKTPLVQEV 690

  Fly   685 HQQFSEYISQVIRIYEGKNLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMIK 749
            ||.||.:.|||:|:|.|:..:|:||.||||...:.:|:||:..|::.:.:.|..||||||||:::
Human   691 HQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILE 755

  Fly   750 RVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLV 814
            |.:|.|.|:... ..:|.|.|||||.:||.:.|...::.||.||:|||:|:.:|.||||:||||:
Human   756 RRRDYRPTWKLN-QTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLL 819

  Fly   815 RDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAER-EAEKEIHLPFWKFFSKNTGSTTA 878
            :|||.||.|.|.|.  |.....||:..::|..:..:.|..| .||:|:..|..........:...
Human   820 KDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNL 882

  Fly   879 AAKSVPSFN----DFPKSVHLLTLEPFNDDEVLLRVEN--FLDHTEGQ----VVSFNIRPIFDYL 933
            .|.....|:    |.|.|||||||..:..:.||||:|:  .:....|:    .|:.|:|.:|...
Human   883 GAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTF 947

  Fly   934 NGVEIRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLHPMQ 998
            ....::||||..|.......|.|: ..::|..|....|              :....::||.||:
Human   948 TITRLQETTLVANQLREAASRLKW-TTNTGPTPHQTPY--------------QLDPANITLEPME 997

  Fly   999 IRTFIIKTE 1007
            ||||:...:
Human   998 IRTFLASVQ 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	155/276 (56%)
		Alpha-mann_mid	359..434	CDD:286360	36/77 (47%)
		Glyco_hydro_38C	482..1002	CDD:285047	174/551 (32%)
MAN2B1	XP_005259970.1	PLN02701	63..1001	CDD:178304	401/1008 (40%)
		GH38N_AMII_LAM_like	63..341	CDD:212121	156/277 (56%)
		Alpha-mann_mid	388..466	CDD:214875	36/77 (47%)
		Glyco_hydro_38C	511..1001	CDD:285047	174/552 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I684
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm40555
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.790