Protein Alignment LManVI and MAN2A1

DIOPT Version :10

• Sequence 1: NP_609253.1
• Gene: LManVI / 34206
• FlyBaseID: FBgn0032069
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_002363.2
• Gene: MAN2A1 / 4124
• HGNCID: 6824
• Length: 1144
• Species: Homo sapiens
• Alignment Length: 1094
• Identity: 293/1094 - (26%)
• Similarity: 473/1094 - (43%)
• Gaps: 237/1094 - (21%)

  Fly    35 TNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFF 99
            |..:.:.:|||||:|.|||||.:.||        ....|||.:.::.:|.:|..|:||..|.|:.
Human   163 TEPLQVFVVPHSHNDPGWLKTFNDYF--------RDKTQYIFNNMVLKLKEDSRRKFIWSEISYL 219

  Fly   100 AKWWAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARP 164
            :|||.......|..|:.|:..|:||...|.|.|.|||..:|.::|||...|.::|::..|  .:|
Human   220 SKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIG--VKP 282

  Fly   165 RIGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDAS-DSLSNDEIFTG 228
            |.||.|||||||...|.:..:.|.......|:.:..|.....:..:|..|..: |..|..:|...
Human   283 RSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCH 347

  Fly   229 LLYRHYSAPPGYCFDV-H-CGDDPII----DTKS-----------------YDNNVKSRVDDFLS 270
            ::       |.|.:|: | ||.||.|    |.|.                 :..||:||....|.
Human   348 MM-------PFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLD 405

  Fly   271 YVTSVAQHYRSNHIMIPMGDDF---QYEDAQVNFKNMDKLIKYVNERQAEGSTF--NLFYSTPAC 330
            .....::.:|:..::.|:||||   :|.:..:.|||..:|..|:|.:    |.|  .:.:.|.:.
Human   406 QYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQ----SKFKVKIQFGTLSD 466

  Fly   331 YLNSLHEGLQTWPNKTQ--------DFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQL 387
            :.::|.:..:|..:|.|        |||.|...|:.||:|||||||..||.:|.....|:.|:.|
Human   467 FFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEIL 531

  Fly   388 SVFAELNTKQQKED----------LEYLREIMGVMQHHDAITGTEKQHVSDDYDRILY------D 436
            ..||.....:.|.:          |...|..:|:.|||||||||.|..|..||...|:      :
Human   532 YYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLE 596

  Fly   437 AILGGVNTA-----RDGLRKLT------------NLPNGEFESCLQLNISECAFTKDDADNVVVT 484
            .|:|  |:|     :|   |||            :|.....:|..|.||...:     |:...:.
Human   597 KIIG--NSAFLLILKD---KLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLS-----AEPRYLV 651

  Fly   485 LYNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNN---DTQHELVFKAS 546
            :||||.......|.|.|.:...:|....|:       ||..||.|:....|   :|.:|:.|:|.
Human   652 VYNPLEQDRISLVSVYVSSPTVQVFSASGK-------PVEVQVSAVWDTANTISETAYEISFRAH 709

  Fly   547 VDKIA--NYYIKKVASQETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGET 609
            :..:.  .|.|.:.||..: ::|.:...|.  |.|::.         :.::||...|   :||.|
Human   710 IPPLGLKVYKILESASSNS-HLADYVLYKN--KVEDSG---------IFTIKNMINT---EEGIT 759

  Fly   610 VVQTSQVKLVIDNKTGLLKTV--EMNGVSENIDQSYGVYRTY----DSGAYVFRQYHQADFIVQY 668
             ::.|.|.|..| :|||:|.:  :.:|....::..:..|.|.    .||||:|.....|...|..
Human   760 -LENSFVLLRFD-QTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYT 822

  Fly   669 EGVEFTVYDGALVKEVHQQFSEYISQVIRIY-----EGK-----NLVEIEWQVGPIEREEEFGRE 723
            ......|..|.:..|| ..|.::::..:|:|     ||:     |:|:|         .:.:.||
Human   823 TPPFVRVTHGRIYSEV-TCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDI---------RKVYNRE 877

  Fly   724 VVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIA 788
            :.:..:|.|.|....|||.||.::..|:.         |.:.|..||.||:|:...:||:|.|:.
Human   878 IAMKISSDIKSQNRFYTDLNGYQIQPRMT---------LSKLPLQANVYPMTTMAYIQDAKHRLT 933

  Fly   789 VLNDRAQGGASMLNGQLELMLHRRLVRDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAA 853
            :|:.::.|.:|:.:||:|:::.|||::||..|:.:.:.:.|      ....::.||  .::.:|.
Human   934 LLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNK------ITANLFRIL--LEKRSAV 990

  Fly   854 EREAEKEI----------------H--LPFWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTLEP 900
            ..|.||:.                |  :|....||..|  .....:..|..:..|..:||:.|..
Human   991 NTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPT--LELQGEFSPLQSSLPCDIHLVNLRT 1053

  Fly   901 F---------NDDEVLLRVENFLDHTEGQVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKRFK 956
            .         |:..::|       |.:|....|:.:       |..:..:|..|.:.:..:.. |
Human  1054 IQSKVGNGHSNEAALIL-------HRKGFDCRFSSK-------GTGLFCSTTQGKILVQKLLN-K 1103

  Fly   957 FHHDSSGQKPDAVEYFTSA-----HKPLAAEQSQEASEFSVTLHPMQIRTFIIK 1005
            |          .||..|.:     |.|...:...|     :.|.||:|.||.|:
Human  1104 F----------IVESLTPSSLSLMHSPPGTQNISE-----INLSPMEISTFRIQ 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	93/300 (31%)
		PLN02701	40..898	CDD:178304	268/966 (28%)
MAN2A1	NP_002363.2	PLN02701	128..1144	CDD:178304	293/1094 (27%)