DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and Man2b1

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006255335.1	Gene:	Man2b1 / 361378	RGDID:	3039	Length:	1021	Species:	Rattus norvegicus

Alignment Length:	1052	Identity:	414/1052 - (39%)
Similarity:	583/1052 - (55%)	Gaps:	118/1052 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFVALL--AISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYG---H---- 63
            ||.::.|  .:...|..:|.||:.||.||..|:|:|::||:|||||||||||||:||   |
  Rat    31 VLSISFLIWLLLAAPGAQAAGYKTCPTTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGMDPHLLTF 95

  Fly    64 ----RSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWWAEQSETAKQVVRKLVNEGRLE 124
                .|::|||.||||:|:||..|:.||.||||.||.:||::||.:|:...:..||.||.:||||
  Rat    96 MPIVMSDVQHASVQYILDSVIYSLLNDPTRRFIYVEMAFFSRWWKQQTNVTQDAVRNLVRQGRLE 160

  Fly   125 FTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYD 189
            |..|.|.||||||.:|.:::||.||||:||.|||||...||:.|.||||||||||||:|||||:|
  Rat   161 FVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFD 225

  Fly   190 GEFFARMDHRDKNDRIDNLGMEMIWDASDSLSND--EIFTGLLYRHYSAPPGYCFDVHCGDDPII 252
            |.|..|:|::||.:|...|.||.:|.||.||...  ::|||:|..:|:.|...|:||.|.|.|::
  Rat   226 GFFLGRIDYQDKFNRKRKLKMEELWRASASLKPPAADLFTGVLPNNYNPPKDLCWDVLCTDPPVV 290

  Fly   253 -DTKSYDNNVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVNE-RQ 315
             |..|.:.|....||.||:..:|..::||:||.::.||.|||||:|.:.||||||||:.||| :|
  Rat   291 DDPTSPEFNANKLVDYFLNLASSQKKYYRTNHTVMTMGSDFQYENANMWFKNMDKLIRLVNEQQQ 355

  Fly   316 AEGSTFNLFYSTPACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHI 380
            |.||..::.||||:|||..|::...||..|..|||||....:.:|||||:|||..||:||...:.
  Rat   356 ANGSKVHVLYSTPSCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNF 420

  Fly   381 LQVAKQLSVFAELNTK---QQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDA----- 437
            |||..||........|   ....|...|.|.|.|:|||||:|||.:|:|.:||.:.|...
  Rat   421 LQVCNQLEALVGPEAKVGPYGSGDSAPLNEAMAVLQHHDAVTGTARQNVVNDYAKQLAAGWGPCE 485

  Fly   438 ILGGVNTARDGLRKLTNLPNGEFESCLQLNISECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVK 502
            :|.....||..|.|      ..|..|.::|||.|. ....:::..|.:|||:.......||:||.
  Rat   486 VLVSNALARLSLYK------QNFSFCREINISICP-ASQTSEHFRVIIYNPVGRKVDLMVRLPVS 543

  Fly   503 NENYEVTDEKGRVVASEV--VPVAWQVLALEFRNNDTQHELVFKASVDKIANYYIKKVASQETKN 565
            ...:.|.|...|.::|.|  ||.|:        :...|.||:|.|||..: .:.|..|......|
  Rat   544 EGIFLVKDPNDRRISSNVVMVPSAY--------SKTYQWELLFPASVPAL-GFSIYSVNKMSGHN 599

  Fly   566 VAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTV 630
            ..||..:.|..|::...|                          |::...::...|:.||||:.:
  Rat   600 HQAHNLTARPKKSKSRVL--------------------------VIENKYIRATFDSDTGLLRKI 638

  Fly   631 EMNGVSENID----QSYGVYRT--------YDSGAYVFRQYHQADFIVQYEGVEFTVYDGALVKE 683
            |  .:.:||.    |.:..|..        ..||||:||..|:....|.: ..:.|:....||:|
  Rat   639 E--NLEQNISLPVRQGFFWYNASAGDEESPQASGAYIFRPSHRKPLPVSH-WAQVTLVKTNLVQE 700

  Fly   684 VHQQFSEYISQVIRIYEGKNLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMI 748
            |||.||.:.|||||:|||:..:|:||.||||..::::|:||:..||:.:.:.|..:|||||||::
  Rat   701 VHQNFSAWCSQVIRLYEGQRHLELEWTVGPIPVKDDWGKEVISRFNTPMRTRGQFFTDSNGREIL 765

  Fly   749 KRVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRL 813
            ||..|.|.|:|.. ..:|.|.|||||.:||.:.|...::.||.||:|||:|:|:|.||||:||||
  Rat   766 KRRDDFRPTWTLN-QTEPVAGNYYPVNTRIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHRRL 829

  Fly   814 VRDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAER-EAEKEIHLPFWKFFSKNTGSTT 877
            :.||..||.|.|.|...|..:  ||:..:|||...::.|..| .||:|:..|  :....:.||:.
  Rat   830 LVDDERGVAEPLLETDTGDKV--RGRHLVILSSVSDAAARHRLLAEQEVLAP--QVVLAHGGSSP 890

  Fly   878 AAAKSVPSF------NDFPKSVHLLTLEPFNDDEVLLRVENFLDHTE------GQVVSFNIRPIF 930
            ..::: |..      .:.|..||||||..:....:|||:|:.....|      ...|:.|::.:|
  Rat   891 YHSQA-PKMQFSALRRELPPQVHLLTLARWGPKMLLLRLEHQFAVKEDSNRNLSSPVTLNLQNLF 954

  Fly   931 DYLNGVEIRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLH 995
            .......::||||..|.|||.:.|.|:..|:.               |::..........|:||.
  Rat   955 KTFTINYLQETTLAANQPLSRVSRLKWMTDTG---------------PISYPAPSRLDPTSITLQ 1004

  Fly   996 PMQIRTFIIKTE 1007
            |||||||:...:
  Rat  1005 PMQIRTFLASVQ 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	152/287 (53%)
		Alpha-mann_mid	359..434	CDD:286360	35/77 (45%)
		Glyco_hydro_38C	482..1002	CDD:285047	178/546 (33%)
Man2b1	XP_006255335.1	GH38N_AMII_LAM_like	63..351	CDD:212121	152/287 (53%)
		Alpha-mann_mid	399..477	CDD:214875	35/77 (45%)
		Glyco_hydro_38C	617..1011	CDD:285047	148/443 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341785
Domainoid	1	1.000	409	1.000	Domainoid score	I670
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I460
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm44691
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770