DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and LManII

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	1107	Identity:	486/1107 - (43%)
Similarity:	670/1107 - (60%)	Gaps:	149/1107 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVLFVALLAI-------SVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHR 64
            :|.|.||..:       |::|....|||::|..||.||:|:|:|.|:|||||||||||||:||..
  Fly     9 LVFFCALGCLIHDADLRSIQPKASQCGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSE 73

  Fly    65 SNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWWAEQSETAKQVVRKLVNEGRLEFTGGA 129
            :.||.||||||||:|:..|::||.:|||.||::||.|||.||....::.|:.||.:|||||.|||
  Fly    74 TKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWWKEQKPKVQEAVKMLVEQGRLEFIGGA 138

  Fly   130 WSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFA 194
            |||||||..:||||||||:.||:.|:||||.|.|||:||||||||||||.||:|||||:||.||.
  Fly   139 WSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFG 203

  Fly   195 RMDHRDKNDRIDNLGMEMIWDASDSLSND-EIFTGLLYRHYSAPPGYCFDVHCGDDPIIDTK-SY 257
            |:|::||::|:.....||||..|.:|..: ::|:|.||.:|.||.|:|||:.|.|.||||.| |.
  Fly   204 RLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGALYNNYQAPDGFCFDILCNDAPIIDGKHSP 268

  Fly   258 DNNVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVNERQAEGSTFN 322
            |||||.|:|.||.:..:.:|:||:|:|::.||.||.|:.|||.:||:||||:|.|||||.||..|
  Fly   269 DNNVKERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNIN 333

  Fly   323 LFYSTPACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQL 387
            |.||||:|||.|||:...|||.|:.|||||.||.::|||||||||||.|||||||||.|||.|||
  Fly   334 LLYSTPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQL 398

  Fly   388 SVFAELNTKQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNTARDGLRKL 452
            |..|....::....|.::||.:|:||||||||||||:.|:.||.:.:..|......|.|:.|.:|
  Fly   399 SALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQL 463

  Fly   453 T-----NLPNG------EFESCLQLNISECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENY 506
            |     |:.:.      ||::|..|||:.|..::.: |...:|||||||||..:|||:||...||
  Fly   464 TVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEAN-DRFALTLYNPLAHTVNEYVRIPVPYSNY 527

  Fly   507 EVTDEKGRVVASEVVPVAWQVLALEFRNNDTQHELVFKA-SVDKIA--NYYIKKVASQETKNVAA 568
            .:.|.||..:.|:.||:...::.::.||:..::|:||.| ::..:.  .||::|:.|.|     .
  Fly   528 RIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATNIPALGYRTYYVEKLDSTE-----G 587

  Fly   569 HTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTVEMN 633
            :|:||          .:|||...|                ||:..|.::|..|. .|.|..|..:
  Fly   588 NTRSK----------ALPKRTSSV----------------TVIGNSHIQLGFDT-NGFLSEVTAD 625

  Fly   634 GVSENIDQSYGVYR----------TYDSGAYVFR----QYHQADFIVQYEGVEFTVYDGALVKEV 684
            |::..:.|.:..|.          ...||||:||    :.|.|.     :.||..||.|.||.||
  Fly   626 GLTRLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFAT-----DQVEIEVYKGDLVHEV 685

  Fly   685 HQQFSEYISQVIRIYEGKNLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMIK 749
            ||:|:::||||:|:|...:..|.||.||||..::..|:||:..|||.|||||:..||||||||||
  Fly   686 HQKFNDWISQVVRVYNKDSYAEFEWLVGPIPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIK 750

  Fly   750 RVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLV 814
            |..:.|:|::..:: :..|.||||:|::|.::|...|:|:|.||||||:|:.:|.||||:||||:
  Fly   751 RKINHRDTWSVKIN-EAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLL 814

  Fly   815 RDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAA-----EREAEKEIHLPFWKFFSKNTG 874
            :||.:||||||||.:||..:|||||.:|....|.:....     ||..:.|..||.||||| |..
  Fly   815 KDDAFGVGEALNETEYGDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKLLPTWKFFS-NME 878

  Fly   875 STTAAAKSVPSFNDF-------PKSVHLLTLEPFNDDEVLLRVENFLDHTE----GQVVSFNIRP 928
            ..:|........|.|       ||.||||||||::::::|:|.|:.:::.|    .|.|.||::.
  Fly   879 DYSADEWQTAFTNIFSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQFNVKN 943

  Fly   929 IFDYLNGVEIRETTLDGNLPLSDMKRFKFHHD---------SSGQKPDAVEYFTSAHKP-LAAEQ 983
            :....:...|||||||||..|.:.:|.:|..|         ::..:|....:..||.|| |..:.
  Fly   944 VLSAFDVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKY 1008

  Fly   984 SQEA----------------------------------------------SEFSVTLHPMQIRTF 1002
            :.||                                              .|:.:.|.||:||||
  Fly  1009 ADEALPAGQLGAESNRIRRETETRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTF 1073

  Fly  1003 II 1004
            |:
  Fly  1074 IV 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	164/275 (60%)
		Alpha-mann_mid	359..434	CDD:286360	47/74 (64%)
		Glyco_hydro_38C	482..1002	CDD:285047	213/608 (35%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	164/275 (60%)
		Alpha-mann_mid	370..445	CDD:214875	47/74 (64%)
		Glyco_hydro_38C	502..957	CDD:285047	189/493 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450127
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	11	10.800