DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and LManIV

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	661/1009 - (65%)
Similarity:	812/1009 - (80%)	Gaps:	33/1009 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYLCGIVLFVA-LLAISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHR 64
            |.|| |.:||:: ||.:..:.||..||||:||:||.||:|||:|||||:||||||||||.:||::
  Fly     1 MTYL-GRILFLSILLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYK 64

  Fly    65 SNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWWAEQSETAKQVVRKLVNEGRLEFTGGA 129
            :.|.|||||||:|:|:::|::||.||||||||:||||||..|||:.|:||.|||||||.||||||
  Fly    65 NKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGA 129

  Fly   130 WSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFA 194
            |||||||.||||.||||||:|||||::|||||.|||:|||||.||||||||:|||.|||||:||:
  Fly   130 WSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFS 194

  Fly   195 RMDHRDKNDRIDNLGMEMIWDASDSLSNDEIFTGLLYRHYSAPPGYCFDVHCGDDPIIDTKSYDN 259
            ||||.||:.|:::|.||||||||:|:|...:|:|:||..||..||:|||:.|.|.||||..|.:|
  Fly   195 RMDHNDKDTRMNDLTMEMIWDASESMSGVSLFSGMLYNFYSDTPGFCFDILCTDQPIIDGDSEEN 259

  Fly   260 NVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVNERQAEGSTFNLF 324
            |||.|||||:||..:|::.|.:||||:|||.|||||||:||:|||||||||:|||||.||.:|:|
  Fly   260 NVKQRVDDFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQASGSKYNIF 324

  Fly   325 YSTPACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSV 389
            ||||:|||||||:.|::|||||||||||..:.||:|||:||||||||||||||||:|||||||||
  Fly   325 YSTPSCYLNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSV 389

  Fly   390 FAELNTKQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNTARDGLRKLTN 454
            .|.|.:::.|.||:|||::||||||||||||||||.|||||||::|:||:|..|.|||.||.|||
  Fly   390 LANLTSEEHKIDLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDALRLLTN 454

  Fly   455 LPNGEFESCLQLNISECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASE 519
            :|.|||||||:|||||||||||.||||:|||||||||:||||||:|||.|||:|||||||.|.||
  Fly   455 MPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQVTDEKGRTVPSE 519

  Fly   520 VVPVAWQVLALEFRNNDTQHELVFKASVDKIANYYIKKVASQETKNVAAHTKSKRSIKAEEANLE 584
            ||||.|||||||:|:|||||||||||:|:|:::|.||||.|.|.|:
  Fly   520 VVPVPWQVLALEYRSNDTQHELVFKATVNKVSSYSIKKVESSEVKH------------------- 565

  Fly   585 VPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTVEMNGVSENIDQSYGVYRTY 649
              ...||::..       :|:..||||:.|.||||:||.||.||:||||||||.|.|::|||:::
  Fly   566 --SSIKKINPR-------EDNNSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIVQNFGVYKSH 621

  Fly   650 DSGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIYEGKNLVEIEWQVGPI 714
            .|.||.|||  ..|..:.....|||||:|:|||||||..:::||||||||||.:.||:||.||||
  Fly   622 TSCAYTFRQ--DGDIELFENDFEFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPI 684

  Fly   715 EREEEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIA 779
            ..:::.|.|.|..|.|.|:|:||.||||||||::|||||:||.|...|.|||.:.|:||||||||
  Fly   685 PIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIA 749

  Fly   780 LQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLVRDDGYGVGEALNEEKYGQPMIARGKVYLIL 844
            |||..||:.:||||:|||||:.:|.||:::|||.:.:||.||||||||.:||:.:|||||:||||
  Fly   750 LQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLIL 814

  Fly   845 -SPSDESTAAEREAEKEIHLPFWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTLEPFNDDEVLL 908
             |.:|..|..||:.|||:.|||||||||..|.....:||:|.|||.|:||||||||.|::.|:|:
  Fly   815 DSATDGDTVTERKTEKELFLPFWKFFSKTGGVEITPSKSLPDFNDLPQSVHLLTLEFFSEQEILI 879

  Fly   909 RVENFLDHTEGQVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFT 973
            |.|:|||.:||:|:|||||.|||.|.|:.|||||||||:|||||||||||...||.||.:|||.|
  Fly   880 RFEHFLDKSEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTKPSSVEYST 944

  Fly   974 SAHKPLAAEQSQEASEFSVTLHPMQIRTFIIKTE 1007
            :.||||.|.:|.|||.|:|||:||||||||||||
  Fly   945 AQHKPLEAVKSDEASLFAVTLYPMQIRTFIIKTE 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	193/273 (71%)
		Alpha-mann_mid	359..434	CDD:286360	59/74 (80%)
		Glyco_hydro_38C	482..1002	CDD:285047	312/520 (60%)
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	193/272 (71%)
		Alpha-mann_mid	359..434	CDD:214875	59/74 (80%)
		Glyco_hydro_38C	483..973	CDD:285047	312/519 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450118
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	12	11.810