Protein Alignment LManVI and Man2a2

DIOPT Version :10

• Sequence 1: NP_609253.1
• Gene: LManVI / 34206
• FlyBaseID: FBgn0032069
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001425115.1
• Gene: Man2a2 / 308757
• RGDID: 1310238
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 1134
• Identity: 291/1134 - (25%)
• Similarity: 473/1134 - (41%)
• Gaps: 292/1134 - (25%)

  Fly    38 INIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKW 102
            :.:.:|||||:|.||:||.|:|:...        .|:|:::::::|.:||.|||:..|.||||||
  Rat   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   103 WAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIG 167
            |...|...:..||:||..|:||...|.|.|.|||..:|.:::||...|.::|:...|  |.||.|
  Rat   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   168 WQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDAS-DSLSNDEIFTGLLY 231
            |.:||||||.....:..:.........|:.:..|........:|.:|..: ||.|:.:||..::
  Rat   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMM- 349

  Fly   232 RHYSAPPGYCFDV-H-CGDDPII----DTKSY-----------------DNNVKSRVDDFLSYVT 273
                  |.|.:|| | ||.||.|    |.|..                 :.||..|....|....
  Rat   350 ------PFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYR 408

  Fly   274 SVAQHYRSNHIMIPMGDDFQYE-----DAQVNFKNMDKLIKYVNER-----QAEGSTFNLFYSTP 328
            ..::.:||:.:::|:||||:|:     |||  |.|..:|..::|.:     ||:       :.|.
  Rat   409 KKSRLFRSSVLLVPLGDDFRYDKPQEWDAQ--FFNYQRLFDFLNSKPEFHVQAQ-------FGTL 464

  Fly   329 ACYLNSLHE--GLQT------WPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAK 385
            :.|.::|::  |::.      :|..:.|||.|...::.|||||:||||..|..:|.....|:.|:
  Rat   465 SEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLETHLRGAE 529

  Fly   386 QLSVFAELNTKQQKEDLEY----------LREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILG 440
            .|...|..:.::.....:|          .|..:|:.|||||||||.|:.|..||
  Rat   530 VLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLFQHHDAITGTAKEAVVVDY---------- 584

  Fly   441 GVNTARDGLRKLTNL----------------------PNGEFESCLQLN--------ISECAFTK 475
            ||..    ||.|.:|                      |...|   ||::        :.|....:
  Rat   585 GVRL----LRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPF---LQMDDSRVSHDALPERTVIR 642

  Fly   476 DDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVV----------ASEVVPVAWQV--- 527
            .|:....|.::|||.......|.:.|.:....|..|:|:.:          |:.:||..:||
  Rat   643 LDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVQWSSATNMVPDVYQVSVP 707

  Fly   528 -------LALEFRNNDTQHELVFKASVDKIANYYIKKVASQETKNVAAHTKSKRSIKAEEANLEV 585
                   |.:.....|.......::||....| .:|...|::|      |...|.:.:..::..:
  Rat   708 VRLPALGLGVLQLQPDLDGPYTLQSSVHVYLN-GVKLSVSRQT------TFPLRVVDSGTSDFAI 765

  Fly   586 PKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTVEMNGVSENIDQS-------Y 643
            ..|:.:|.                          ....|||||:|..  |.|..:|.       |
  Rat   766 SNRYMQVW--------------------------FSGLTGLLKSVRR--VDEEQEQQVDMKLFVY 802

  Fly   644 GVYRTYD-SGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIY-----EGK 702
            |...:.| ||||:|...::|...|..:.....|.:|....|| ..:.|:..||||:|     ||.
  Rat   803 GTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEV-AAYYEHFHQVIRLYNLPGVEGL 866

  Fly   703 NLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNG-----REMIKRVKDQRETFTPGL 762
            :| ::.:||   :..:...:|:.:..::.|.|.|..:||.||     |:.:|::
  Rat   867 SL-DVSFQV---DIRDYVNKELALRIHTDIDSQGTFFTDLNGFQVQPRKYLKKL----------- 916

  Fly   763 DRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLVRDDGYGVGEALNE 827
               |..||:||:.....:|||::|:.:...:|.|.:|:.|||||::|.|||::||..|:|:.|.:
  Rat   917 ---PLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKD 978

  Fly   828 EK----YGQPMIARGKVYLILSPS----------------DESTAAEREAEKEIHLPFWKFFSKN 872
            .|    :.:.::.|   ..::||.                ..:|....:.::|....:....|..
  Rat   979 NKITCNHFRLLLER---RTLMSPEPGFFSKLAAMFRGLIFSSNTIRNSKVQQERSTSYPSLLSHM 1040

  Fly   873 TG----------------STTAAAKSV-PSFNDFPKSVHLLTLE--------PFNDDEVLLRVEN 912
            |.                ||:....|. |..:..|...|||.|.        |..|..::|..:.
  Rat  1041 TSMYLNTPPLVLPVAKRESTSPTLHSFHPLASPLPCDFHLLNLRMLPAEDTLPAADAALILHRKG 1105

  Fly   913 FLDHTEGQVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKRFKFHH-DSSGQKPDAVEYFTSAH 976
            |....|.:.:.||.              ||..|.|.|..:    ||. |....:|.::...
  Rat  1106 FDCGLEAKNLGFNC--------------TTSQGKLALGSL----FHGLDVLFLQPTSLTLL---- 1148

  Fly   977 KPLAAEQSQEASEFSVTLHPMQIRTFIIK 1005
            .|||:    .::...::|.||:|.||.::
  Rat  1149 YPLAS----PSNSTDISLEPMEISTFRLR 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	98/302 (32%)
		PLN02701	40..898	CDD:178304	265/1014 (26%)
Man2a2	NP_001425115.1	None