Protein Alignment LManVI and MAN2B2

DIOPT Version :9

• Sequence 1: NP_609253.1
• Gene: LManVI / 34206
• FlyBaseID: FBgn0032069
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_056089.1
• Gene: MAN2B2 / 23324
• HGNCID: 29623
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 1118
• Identity: 304/1118 - (27%)
• Similarity: 473/1118 - (42%)
• Gaps: 228/1118 - (20%)

  Fly     1 MKYLCGIVLFVALLAISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHRS 65
            |..||.:.|...||.:. .|..::.|          .|...:|||||.||||:.||.:....:.:
Human     1 MGQLCWLPLLAPLLLLR-PPGVQSAG----------PIRAFVVPHSHMDVGWVYTVQESMRAYAA 54

  Fly    66 NIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWW-AEQSETAKQVVRKLVNEGRLEFTGGA 129
            |        :..:|:.||.:...||||.||..||..|| ...|:..|..||:|:.||||||..|.
Human    55 N--------VYTSVVEELARGQQRRFIAVEQEFFRLWWDGVASDQQKYQVRQLLEEGRLEFVIGG 111

  Fly   130 WSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFA 194
            ..|:|||..:....|.|.|.|..||.:|||  .||:..|.:||||.|....::||..|::....:
Human   112 QVMHDEAVTHLDDQILQLTEGHGFLYETFG--IRPQFSWHVDPFGASATTPTLFALAGFNAHLGS 174

  Fly   195 RMDHRDKNDRIDNLGMEMIWDASDSLS-NDEIFTGLLYRH-YSAPPGYCFDVHCG---------- 247
            |:|:..|....:..|::.:|..|.||| ..||||.::.:: |..|....|....|
Human   175 RIDYDLKAAMQEARGLQFVWRGSPSLSERQEIFTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFP 239

  Fly   248 -----------DDPIIDTKSYDNNVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNF 301
                       .:|:...     |:....:..::.|...|..:|:.|::.|.|.|.|:.:|.|.|
Human   240 KPPQDGVYPNMSEPVTPA-----NINLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQF 299

  Fly   302 KNMDKLIKYVNERQAEGSTFNLFYSTPACYLNSLHEGLQTWPNKT-QDFFPYGSDDNSYWTGYFT 365
            .|||.|:.::|...||... ::.|:|...|..:||....||..:. .||.||.::....|||::|
Human   300 ANMDPLLDHINSHAAELGV-SVQYATLGDYFRALHALNVTWRVRDHHDFLPYSTEPFQAWTGFYT 363

  Fly   366 SRPTQKRFERDGNHILQVAKQLSVF---------AELNTKQQKEDLEYLREIMGVMQHHDAITGT 421
            ||.:.|...|..:.:|...:  |:|         ..|:.....:.|:.||..:..:|||||||||
Human   364 SRSSLKGLARRASALLYAGE--SMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGT 426

  Fly   422 EKQHVSDDYDRILYDAILGGVNTARDGLRKL-TNLPNGEFESCLQLNISECAFTKDDADNVVVTL 485
            |...|.|.|...|...:|        |:||| .::...|    ||......|.:.........::
Human   427 ESPKVRDMYATHLASGML--------GMRKLMASIVLDE----LQPQAPMAASSDAGPAGHFASV 479

  Fly   486 YNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNNDTQ----HELVFKAS 546
            |||||.|.|..|.:.|......||||.|..|.|::             .|.|:    ::|:...:
Human   480 YNPLAWTVTTIVTLTVGFPGVRVTDEAGHPVPSQI-------------QNSTETPSAYDLLILTT 531

  Fly   547 VDKIA--NYYIKKVA-SQE-TKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEG 607
            :..::  :|.|:..| :|| |:..||...|         .|:..:|.::..|          ..|
Human   532 IPGLSYRHYNIRPTAGAQEGTQEPAATVAS---------TLQFGRRLRRRTS----------HAG 577

  Fly   608 ETVVQTSQ--VKLVIDNKTGLLKTV--EMNGVSENIDQSYGVYRTYD-------SGAYVFRQYHQ 661
            ..:|..:.  ..:::|..|.|:.::  ..:..:..:.|.:..|....       |..|:|.....
Human   578 RYLVPVANDCYIVLLDQDTNLMHSIWERQSNRTVRVTQEFLEYHVNGDVKQGPISDNYLFTPGKA 642

  Fly   662 ADFIVQYEGVEFTVYDGALVKEVHQQF------SEY-------ISQVIRIYEGKNL---VEIEWQ 710
            |  :..:|.||..:..|.||.|:.|.|      ..|       ::.|.:.::|:.|   :|.|:|
Human   643 A--VPAWEAVEMEIVAGQLVTEIRQYFYRNMTAQNYTYAIRSRLTHVPQGHDGELLCHRIEQEYQ 705

  Fly   711 VGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVT 775
            .||:    |..||.|:..::.:.|..|.|:|:||.:|      ||..:...::.. .|.||||:.
Human   706 AGPL----ELNREAVLRTSTNLNSQQVIYSDNNGYQM------QRRPYVSYVNNS-IARNYYPMV 759

  Fly   776 SRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLVR----DDGYGVGEALNEEKYGQPMIA 836
            ....::|.|.|:.:|::||.|.:|..|||:|:||||||..    |.||.:  .||:.....|::
Human   760 QSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNL--TLNDTSVVHPVL- 821

  Fly   837 RGKVYLILSPSDESTA-AEREAEKEIHLPFWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTLEP 900
                :|:|.....:|| .:|.|....|.|...|     |.....|..:|.    |:....:||.|
Human   822 ----WLLLGSWSLTTALRQRSALALQHRPVVLF-----GDLAGTAPKLPG----PQQQEAVTLPP 873

  Fly   901 ---------------FNDDE-------------------VLLRVENFLDHTE----GQVVSFNIR 927
                           .|..|                   ||||:.:..:..|    .|.|:.|:.
Human   874 NLHLQILSIPGWRYSSNHTEHSQNLRKGHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVTVNLE 938

  Fly   928 PIFDYLNG-VEIRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFS 991
            .:...|.. |.:.|.:|.|...||.:.|:.:.......:.|.    ||..:|....        .
Human   939 AVLQALGSVVAVEERSLTGTWDLSMLHRWSWRTGPGRHRGDT----TSPSRPPGGP--------I 991

  Fly   992 VTLHPMQIRTFII 1004
            :|:||.:||||.|
Human   992 ITVHPKEIRTFFI 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	96/297 (32%)
		Alpha-mann_mid	359..434	CDD:286360	28/83 (34%)
		Glyco_hydro_38C	482..1002	CDD:285047	145/598 (24%)
MAN2B2	NP_056089.1	GH38N_AMII_Epman_like	27..352	CDD:212122	110/340 (32%)
		Alpha-mann_mid	358..439	CDD:214875	28/82 (34%)
		Glyco_hydro_38C	581..1002	CDD:285047	113/461 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..991		4/30 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7020
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870