DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and man2a2

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_009296075.1	Gene:	man2a2 / 100333987	ZFINID:	ZDB-GENE-110331-1	Length:	1174	Species:	Danio rerio

Alignment Length:	1099	Identity:	273/1099 - (24%)
Similarity:	452/1099 - (41%)	Gaps:	223/1099 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 INIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKW 102
            :.:.:|||||:|.||:||.|:|:     |.|   .|:|::.::.::.:||.|:||..|.|:||||
Zfish   166 LQVFVVPHSHNDPGWIKTFDKYY-----NDQ---TQHILNNMVTKMAEDPRRKFIWSEISYFAKW 222

  Fly   103 WAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIG 167
            |.......::|:|||:..|:||...|.|.|.|||..:|.::|||...|.::|:...|  ..||.|
Zfish   223 WESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLG--VTPRSG 285

  Fly   168 WQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIW-DASDSLSNDEIFTGLLY 231
            |.:||||||.....:..:.........|:.:..|........:|.:| .|.|..|:.::|..::
Zfish   286 WAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMM- 349

  Fly   232 RHYSAPPGYCFDV-H-CGDDPII----DTKSY-----------------DNNVKSRVDDFLSYVT 273
                  |.|.:|| | ||.||.|    |.|..                 |.||..|....|....
Zfish   350 ------PFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYR 408

  Fly   274 SVAQHYRSNHIMIPMGDDFQYEDA---QVNFKNMDKLIKYVNER-----QAEGSTFNLFYSTPAC 330
            ..::.:||..:::|:||||:|:.|   ...:.|..||..|:|..     :|:.:|.:.::.  |.
Zfish   409 KKSKLFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPEMHVKAQFATLSDYFD--AV 471

  Fly   331 Y-LNSLHEGLQ--TWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSVFAE 392
            | .|.:..|.:  .:|..:.|||.|...::.||:||:||||..|..:|.....|:.|:.|...|.
Zfish   472 YKANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLAV 536

  Fly   393 LNTKQQKEDLEY----------LREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILG----GVN 443
            .:.:....:..|          .|..:|:.|||||||||.|:.|..||...|..:::|    .:|
Zfish   537 AHARHAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIIN 601

  Fly   444 TA-------RDGLRKLTNLPNGEFES--CLQLNISECAFTKDDADNVVVTLYNPLAHTSTQYVRV 499
            .|       :|..|.....|..|.:.  ..|.::.:....:.::....:.|:||:.......|.|
Zfish   602 AAHFLIIKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELESSPRYLVLFNPVEQERLCLVTV 666

  Fly   500 PVKNENYEVTDEKGRVVASEVVPV---AWQVLALEFRNNDTQHELVFKASVDKIANYYIKKVASQ 561
            .|.:....|..|.|     :.:||   |..:.|.|......|...:.:.....:|.:::...|.
Zfish   667 LVNSARVRVLTEDG-----QTLPVQLSAQWMSATEMSGEVYQASFMARLPALGLAVFHLYDSAD- 725

  Fly   562 ETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGET-VVQTSQVKLVIDNKTG 625
                      |..::::|.. |.||.|.:.:..|..........:|:. .:|:..:.|.....||
Zfish   726 ----------SPMTLRSETL-LRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSLTLGFSGATG 779

  Fly   626 LLKTVEMNGVSENID-----QSYGVYRTYD-SGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEV 684
            ||:::......:.:.     .:||...:.| ||||:|.....|....|.|.....|.:|.|..||
Zfish   780 LLESIRRKDDPQEVRVQIQFLTYGTRPSKDKSGAYLFLPDGNAKPYSQREAPIVRVVEGPLFAEV 844

  Fly   685 HQQFSEYISQVIRIYEGKNLVEIEWQVGP-IEREEEFGREVVIIFNSTIASDGVSYTDSNGREMI 748
            ...: ::..|.:||:....:..:...:.. ::..::..:|:.:.|.:.|.|....|||.||.::
Zfish   845 VAHY-QHFQQTVRIHNVPGVDGLSLDITTMVDIRDQNNKELAMRFVTDIQSGDTFYTDLNGFQI- 907

  Fly   749 KRVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRL 813
                ..|..|    .:.|..||:||:.|...:|||:.|:.:...:|.|..|:.:||||::|.|||
Zfish   908 ----QPRRYF----QKLPLQANFYPMPSTAYIQDSQYRLTLHTAQALGVTSLASGQLEVILDRRL 964

  Fly   814 VRDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAEREAEKEIHLPFWKFFSKNTGSTTA 878
            ::||..|:|:.|.:.|.     ...:..|:|         ||.:.
Zfish   965 MQDDNRGLGQGLKDNKR-----TANRFRLLL---------ERRSN-------------------- 995

  Fly   879 AAKSVPSFNDFPKSVHLLTLEPFNDDEVLLRVENF---LDHTEGQVVSFNI--RPIFDYLNGVEI 938
            :||...|:.:....:....|....::.|..|..:|   |.|....:::..:  .|:....:||..
Zfish   996 SAKPAGSYANMLNKIIAGILGDGQEEPVDSRPVSFPSLLSHMTSTILNHEVLALPVLPRKHGVPP 1060

  Fly   939 RET--TLDGNLPLSDMKRFKFH--HDSSGQKPDAVEYFTSAHKP--------------------- 978
            ..|  .|.|.||..      ||  :..|.|.|.      .||.|
Zfish  1061 MRTFAPLAGTLPCD------FHLLNLRSIQSPQ------DAHSPSPYMALLLHRLGLDCGLEPQN 1113

  Fly   979 --------------------------------LAAEQSQEASEFSVTLHPMQIRTFIIK 1005
                                            |...|...:::.||:|.||:|..:.:|
Zfish  1114 PGFNCTTTQGQLSVSGLFRGLDLQLLQPMSLSLMHSQPPLSNDSSVSLEPMEISAYKLK 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	96/300 (32%)
		Alpha-mann_mid	359..434	CDD:286360	30/84 (36%)
		Glyco_hydro_38C	482..1002	CDD:285047	125/592 (21%)
man2a2	XP_009296075.1	PLN02701	128..1173	CDD:178304	273/1099 (25%)
		CE4_SF	165..508	CDD:301698	111/360 (31%)
		Alpha-mann_mid	503..588	CDD:214875	30/84 (36%)
		Glyco_hydro_38C	741..1169	CDD:285047	103/483 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910