DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and man2b2

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001106515.1	Gene:	man2b2 / 100127706	XenbaseID:	XB-GENE-1006292	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	1109	Identity:	312/1109 - (28%)
Similarity:	471/1109 - (42%)	Gaps:	234/1109 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVLFVALLAISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAG 71
            |||.|.|.|...     .|.:.|.|      |...::||||.||||:.||.:..:.:.:|
Frog     2 IVLLVLLSAWGC-----VCTHSAQP------IQAFVIPHSHMDVGWVYTVQESMHAYAAN----- 50

  Fly    72 VQYIIDTVIAELIKDPARRFIQVETSFFAKWW-AEQSETAKQVVRKLVNEGRLEFTGGAWSMNDE 135
               :..||:.||::...||||.||..||..|| .......||.|.:|:.||||||..|...|:||
Frog    51 ---VYTTVVEELMRGDRRRFIVVEQEFFRLWWKLFAGNVEKQQVHQLMREGRLEFVIGGQVMHDE 112

  Fly   136 AAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRD 200
            |.......|.|.|.|..|:.:|||  .|||..|.:||||.|....::||..|::|...:|:|:..
Frog   113 ALTTIDDQILQLTEGHGFIYETFG--VRPRFSWHVDPFGASAASPTLFAMAGFNGHLISRIDYDT 175

  Fly   201 KNDRIDNLGMEMIWDASDSLSN-DEIFTGLLYRHYSAPPGYC-FDVHCG---------DDPIIDT 254
            |.|..:...::.||.||.|||: .||||.::.::....|.|. |....|         .||..|.
Frog   176 KADMQNGKELQFIWRASPSLSDKQEIFTHVMDQYSYCTPSYIPFSDRSGFYWNGIAVFPDPPKDG 240

  Fly   255 KSYDNNVKSRVDDFLSYVTSVAQH-------YRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVN 312
            ...:.::....|....|..::.::       :||:.::.|.|.|.|:.:|.|.|.|||.|:.|:|
Frog   241 MYPNMSLPVTADTIHPYAETMVKNIKERAAWFRSSDVLWPWGCDKQFFNASVQFNNMDLLLDYIN 305

  Fly   313 ERQAEGSTFNLFYSTPACYLNSLHEGLQTWPNK-TQDFFPYGSDDNSYWTGYFTSRPTQKRFERD 376
            :....|.|..  |||...|..:|:....||..: :|||.||.||.:..|||::|||...|...|.
Frog   306 KHTEFGVTVQ--YSTLGDYFKNLYNRNLTWGLRGSQDFLPYSSDSSQAWTGFYTSRNVLKGVARR 368

  Fly   377 GNHILQVAKQLSVFAELNTKQ---------QKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDR 432
            .:.:|..|:  |.||:...|.         ..|.|..||..:..:||||.|||||...|.|.|
Frog   369 ASSLLYAAE--SAFAQHLLKHPTGSVEKVWAMEQLRSLRWAVSEVQHHDGITGTESPKVRDMY-- 429

  Fly   433 ILYDAILGGVNTARDGLRKL-----TNLPNGEFESCLQLNISECAFTKDDADNVVVTLYNPLAHT 492
             :.:.:.|..     |:|||     .:|.:.:..||....|:             :|:|||||..
Frog   430 -IANLLQGAA-----GVRKLMAAIVMDLYSSQANSCGNGYIN-------------ITVYNPLAWD 475

  Fly   493 STQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNNDTQHELVFKASVDKIANY--YI 555
            .|.:|.||:.|....|.|:.|:.|.:::..      |.|..|....|.||    ..|..:|  |.
Frog   476 VTTFVLVPMNNSVSGVYDKFGQPVPAQIQN------ATEPSNAFDLHILV----TLKGLSYGRYS 530

  Fly   556 KKVASQETKN--------VAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGETVVQ 612
            .|:.|.:..|        :....:.||: ||:..||..|                        :.
Frog   531 IKLGSCDAANDRLVTGRKITFVRQPKRN-KAKRQNLVTP------------------------IM 570

  Fly   613 TSQVKLVIDNKTGLLKTVEMNGVSENIDQSYGVYRTYDSG---------AYVFRQYHQADFIVQY 668
            .....:|||..|.||.::.....::.:..:......:.:|         .|:|.....|  |..|
Frog   571 NDCYTVVIDQNTNLLHSITARESNQTVQVTQEFLEYHSNGDISKGPISDNYLFTSTGPA--ISAY 633

  Fly   669 EGVEFTVYDGALVKEVHQQFSEYI----------SQVIRIYEG--KNLV----EIEWQVGPIERE 717
            :.|...:..|.||.|:.|.|...|          |::..:.||  |:||    |..::|||:
Frog   634 KAVGLEIIAGKLVTEIRQYFYSNITAQTYLYAVYSRIYNVPEGYDKSLVCHHIEQSYRVGPM--- 695

  Fly   718 EEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIALQD 782
             :..||.:|..::.:.:|.:.|||:||.:|      ||..| ...|....|.||||:.....::|
Frog   696 -DLNRESIIRTSTDLRTDRLIYTDNNGYQM------QRRQF-KNYDTNTVARNYYPMVRTAYIED 752

  Fly   783 SKKRIAVLNDRAQGGASMLNGQLELMLHRRLVR----DDGYGVGEALNEEKYGQPMI-------- 835
            :..|:..|::||.|.:|..||::|:||||||..    |..|.:  .||:....:|.|
Frog   753 NSTRLVFLSERAHGVSSQDNGEVEIMLHRRLWNNLEWDLNYNL--TLNDTSVVRPTIWLMLGSRA 815

  Fly   836 ARGKVYLILSPSDESTAAEREAEKEIHLPFWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTL-- 898
            ..|.:|..|..:.|            |.|. ..:|.:||....:.|:.......|.::||..|
Frog   816 LAGALYQRLGMALE------------HRPL-VIYSLHTGQEKRSYKTTDLPITLPDNIHLQILSI 867

  Fly   899 ----------EPFND-------------DEVLLRVENFLDHTEGQV----VSFNIRPIFDYLNGV 936
                      |...|             ..||||:::..:..|..|    |:.|::.:...|..|
Frog   868 PGWFYSSRHHEHMQDIHTGNIRDNVADFHRVLLRLQHLYETNEDPVLSKPVTINLQSLLKGLGTV 932

  Fly   937 E-IRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLHPMQIR 1000
            . :.|.:|.|...:..:||:|:..:..|..              ..|.:...|:|::||.|.:||
Frog   933 SLVEERSLTGTWDIHTLKRWKWKANIKGTD--------------QREHTLGTSDFTITLSPKEIR 983

  Fly  1001 TFII 1004
            |..:
Frog   984 TLFV 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	100/292 (34%)
		Alpha-mann_mid	359..434	CDD:286360	30/83 (36%)
		Glyco_hydro_38C	482..1002	CDD:285047	146/596 (24%)
man2b2	NP_001106515.1	GH38N_AMII_Epman_like	22..346	CDD:212122	115/335 (34%)
		Alpha-mann_mid	352..433	CDD:214875	30/85 (35%)
		Glyco_hydro_38C	567..985	CDD:285047	113/483 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020