DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and man2b2

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_001337519.3	Gene:	man2b2 / 100003570	ZFINID:	ZDB-GENE-140106-166	Length:	1006	Species:	Danio rerio

Alignment Length:	1095	Identity:	304/1095 - (27%)
Similarity:	493/1095 - (45%)	Gaps:	196/1095 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FVALLAISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQY 74
            |..||.::|..::.|           ..|...::||||.||||:.||.:..:.:.||
Zfish     6 FFGLLLMTVSENDAA-----------EKIQAFVIPHSHMDVGWVYTVQESMHAYASN-------- 51

  Fly    75 IIDTVIAELIKDPARRFIQVETSFFAKWWAE-QSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAV 138
            :..||:.||.:...|:||.||..||..||.. .|:..|:.||:|:.||||||..|...|:|||..
Zfish    52 VYSTVVEELTRVKNRKFIAVEQEFFRLWWTNVASDWHKKQVRQLLLEGRLEFIIGGQVMHDEAVT 116

  Fly   139 NYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKND 203
            :....|.|.|.|..||.:|||  .|||..|.:||||.|.....:||..|:|....:|:|:..|:|
Zfish   117 DVDDAILQLTEGHGFLYETFG--VRPRFAWHVDPFGASATTPVLFALAGFDAHLISRIDYDLKDD 179

  Fly   204 RIDNLGMEMIWDASDSL-SNDEIFTGLLYRHYSAPPGYC-FDVHCG---------DDPIIDTKSY 257
            ...|..::.:|..|.:| ...||||..:.:.....|.|. |....|         .||..|.| |
Zfish   180 MQKNKKLQFVWRGSPTLKEKQEIFTHTMDQFSYCTPSYIPFSNRSGFYWNGVALFPDPPKDGK-Y 243

  Fly   258 DN--------NVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVNER 314
            .|        .|:......:..:...||.:||:|::.|.|.|.|:.:|.|.|.|||.|:.|:|..
Zfish   244 PNMSLPVTKETVELYAQTMVDNIRLRAQWFRSSHVLWPWGCDKQFYNASVQFSNMDVLMNYINTH 308

  Fly   315 QAE-GSTFNLFYSTPACYLNSLHEGLQTWPNK-TQDFFPYGSDDNSYWTGYFTSRPTQKRFERDG 377
            ..: |.|..  |:|...|..:||:...:|..: .|||.||.::....|||::.||...|...|..
Zfish   309 SDQYGVTVQ--YATLKDYFQTLHQTNLSWDVRGNQDFLPYSTEPFQAWTGFYGSRNVLKGVARRA 371

  Fly   378 NHILQVAKQLSVFAELNTKQ-----QKE----DLEYLREIMGVMQHHDAITGTEKQHVSDDYDRI 433
            :.:|..::  |:|...:...     |:|    .|:.||..:..:||||.|||||...|:|.|
Zfish   372 SSLLYASE--SLFTRYHISYPDGPVQREWALSKLKALRWAVSEVQHHDGITGTESPKVADMY--- 431

  Fly   434 LYDAILGGVNTARDGLRKLTNLPNGEFESCLQLNISECAFT-KDDADNVV---VTLYNPLAHTST 494
             .:.:|.|:..|.:.|..:..||. ...:.:...|.....| :.|::||.   :.:|||||...:
Zfish   432 -MEHLLQGMMGAEELLAAIFLLPQ-TLSNDIYDQIKNTPTTARTDSENVPEQHIFVYNPLAWNIS 494

  Fly   495 QYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNNDTQHELVFKASVDKIANYYIKKVA 559
            .||.|.|:.....|.|:.|:.|.:::.|      ::|   :.|.::|.|   |.::.....:|..
Zfish   495 TYVNVSVQYAMAVVLDDDGKAVPAQIQP------SME---SSTVYDLFF---VVELGGLQYRKYT 547

  Fly   560 SQ------ETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGETV--VQTSQV 616
            .|      :|.:....|...:.:|..:.|:   :::||.              |..:  |.....
Zfish   548 VQFPQSPCDTGSACGATHVAKVVKFNKTNV---RQWKKT--------------GRKLLPVLNECY 595

  Fly   617 KLVIDNKTGLLKTV--EMNGVSENIDQSYGVYRT---YDSGA----YVFRQYHQADFIVQYEGVE 672
            ||:.|.:|.||.::  ....:...:.|.:..|:.   ..||.    |:|.....|  :..|:.|.
Zfish   596 KLMFDQETNLLHSITDRSKKIRVRVQQDFWEYKANGDVQSGPISDNYIFTANGSA--VPAYKSVV 658

  Fly   673 FTVYDGALVKEVHQQF-------SEYISQVIRI---YEGK---NLVEIEWQVGPIEREEEFGREV 724
            ..:..|.::.|:.|.|       :...|.|.|:   ::|:   ..:|..::|||:    |..||.
Zfish   659 MEIVPGKVISEIRQYFYREEEDANHTYSVVTRVPVGFKGRLSCFRLEQSYKVGPL----EVNRET 719

  Fly   725 VIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAV 789
            |....:::.::...:||:||.:|:||      |: .|......|.||||:.....::|...|:..
Zfish   720 VFRTRTSLQNNRTLFTDNNGYQMMKR------TY-KGYANNTVARNYYPMVRVAYMEDESSRVVF 777

  Fly   790 LNDRAQGGASMLNGQLELMLHRRLVR----DDGYGVGEALNEEKYGQPMIARGKVYLIL-SPSDE 849
            |::||.|.||:..||||:||||||..    :.||.:  .||:....:|::     :::| ||...
Zfish   778 LSERAHGVASLSQGQLEVMLHRRLWNNQEWNQGYNL--TLNDSSVVRPVL-----WMMLGSPDSL 835

  Fly   850 STAAEREAEKEIHLPFWKFFSK-----NTGSTTAAAKSVPSFND--FPKSVHLLTL--------- 898
            |:..::||.:..|.|......:     |...|.    |.||.:.  .|:::|:.:|
Zfish   836 SSIYQQEAVELQHRPVVMAIDQPQKLLNQRETF----SGPSVHPVVLPQNLHMQSLSIPGWNYSP 896

  Fly   899 ---------EPFNDDEVLLRVENFLDHTEGQVVS----FNIRPIFDYLNGV-EIRETTLDGNLPL 949
                     ...|.|.:|||:.:..:..|..|:|    .|::.:...:..| :::|.:|.|...:
Zfish   897 EHSSGGDEKSEVNFDRILLRITHLYEEGESPVLSQPTTINLKEVMQGIGKVSKVQECSLTGTWNI 961

  Fly   950 SDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLHPMQIRTFII 1004
            ||::|:.:..|.:.||.|...:            |....:|:||:.|.:||||.|
Zfish   962 SDLQRWNWKTDETMQKTDKSGF------------SGVTQDFNVTISPKEIRTFFI 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	104/293 (35%)
		Alpha-mann_mid	359..434	CDD:286360	27/83 (33%)
		Glyco_hydro_38C	482..1002	CDD:285047	140/587 (24%)
man2b2	XP_001337519.3	PLN02701	20..1002	CDD:178304	297/1077 (28%)
man2b2	XP_001337519.3	GH38-57_N_LamB_YdjC_SF	23..348	CDD:330225	118/337 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920