DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and man2b1

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001072469.1	Gene:	man2b1 / 779924	XenbaseID:	XB-GENE-958698	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	1011	Identity:	412/1011 - (40%)
Similarity:	590/1011 - (58%)	Gaps:	72/1011 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLCVAFLALQA----KSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQ 67
            :|.:..|.|.|    |.|:. ||.:||.:.....:|:||:||:|:||||||||||||||..|:||
Frog     6 LLLLPLLLLGAAGRLKQAEG-CGEQSCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQ 69

  Fly    68 HAGVQYIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMN 132
            |||||||:|:|:|:|:.:|.:|||.||::||.:||.:|.|.:|..|..||.||||:||||.||||
Frog    70 HAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMN 134

  Fly   133 DEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDH 197
            ||||.:|.|:|||.|:||:||..|||.||||||.|.|||||||||||.::||||:||.||.|:|:
Frog   135 DEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDY 199

  Fly   198 NDKGRRMNDLALEMIWDASESLS--QVKLFTGLLYTFYWDTPGFCFDVHCSDDPIIDSDSY-DNN 259
            .||..|.....:||:|.||:.:|  ...||||:|...|....|||:|..|.|.||||..|. |.|
Frog   200 QDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYN 264

  Fly   260 VKSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIY 324
            ....|..|:..|.|.|:|:.::||::.||.|||||:|.:.:||||:|||.||.:|.:|||.|:.|
Frog   265 ADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFY 329

  Fly   325 STPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSA- 388
            |||:|||.|:|::..::|.|..|||||....:.|||||:||||..|.:||..|:.|||..|:.|
Frog   330 STPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEAL 394

  Fly   389 ---------FAELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTA 444
                     :.:.|||       .:|..|||.|||||:|||.||||::||...|.:.........
Frog   395 SGLEARNGPYGQSSST-------VMRRAMGVAQHHDAVTGTAKQHVNNDYSLRLSEGWDSCQVVI 452

  Fly   445 GDALRKLTNLPNGEFESCLQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTD 509
            .::|..||.... .|..|..||||.|..| :.|:|..|.|||.|..:....||:||....|:|..
Frog   453 SNSLSSLTGTKE-NFAFCNLLNISVCHVT-ETANNFKVYLYNPLGRSVTWTVRLPVNGHAYKVIG 515

  Fly   510 EKGRVVASEIVPVPAEVLALEFRDSDTQHELVFKASVDKI--ANYYIKKVDSKESSNGVRVISQP 572
            .....|.||:|.|.....||.|:....:.||:|:..:..:  :::.:.|:...:     |.:.:.
Frog   516 PNDETVPSEVVDVSDFTKALRFQQGGAERELIFQGQIPAVGFSSFTVGKLSLPD-----RFVIKG 575

  Fly   573 KANAETYDDEETIVQTSLIKLVLDNKTGLLKRVE--MNGVSENIEQSYGLYR--------TYDSG 627
            |...:..|.    :|....::..|.:|||:..:.  ...:|..::||:..|.        :..||
Frog   576 KRGKKQPDK----IQNQYYRVDFDPETGLISGIHNLEKKISLPLKQSFYWYNASVGNEESSQPSG 636

  Fly   628 AYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPVE 692
            ||:||. |..|.|.....|...:...:||:||||.||.:.|||:|:..|:.|:|.||.|||:|:.
Frog   637 AYIFRP-NNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIG 700

  Fly   693 EEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQD 757
            :|:|.||:::..:.:.::||||||||||::::|.:|.||.:... ..:|.:|||||:.|||.::.
Frog   701 DEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLN-QTEPIAGNYYPVNSRIYIKG 764

  Fly   758 SNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEE-KYGQPLIARGKVFLILNA 821
            .|.::.:|.||:|||:|::||.:|||:||||:|||..||||.|.|. ..|:.::.||:..|:|:.
Frog   765 KNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDH 829

  Fly   822 ADESTSAEREAEKEFHLPLWKFFSKNTG-----STTAAAKSVPSFDDFPKSVHLLTLEPFNDDEI 881
            |||:....|....:.::......|...|     |.|...|......:.|::.||||......|:|
Frog   830 ADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMHAADKI 894

  Fly   882 LLRVENFKDHIEGK----VVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKFHAEGSGIRGS 942
            |||:|:.....|.|    .::.|:..:|..::.....||||..|:..|.:|:.::..     |..
Frog   895 LLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKRLQWRT-----RTG 954

  Fly   943 EPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFI 978
            .|....|...|:     .|.:.  :||.||:||||:
Frog   955 SPLQMDSPRAPV-----VDPSN--ITLSPMEIRTFL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	158/276 (57%)
		Alpha-mann_mid	358..433	CDD:286360	39/84 (46%)
		Glyco_hydro_38C	481..977	CDD:285047	166/517 (32%)
man2b1	NP_001072469.1	PLN02701	39..987	CDD:178304	402/977 (41%)
man2b1	NP_001072469.1	GH38N_AMII_LAM_like	39..317	CDD:212121	159/277 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I465
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm47730
Panther	1	1.100	-	-	O	PTHR11607
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160