DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and man2a1

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001103497.2	Gene:	man2a1 / 560219	ZFINID:	ZDB-GENE-060526-31	Length:	1150	Species:	Danio rerio

Alignment Length:	1072	Identity:	268/1072 - (25%)
Similarity:	438/1072 - (40%)	Gaps:	207/1072 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 HETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVE 94
            :|..:..:.:.:|||||:|.|||||.|.||   |:..||     |::.::.:|.::..|:.|..|
Zfish   157 NEWDNEPLQVFVVPHSHNDPGWLKTFDDYY---RDQTQH-----ILNNMVVKLHEDSRRKMIWSE 213

  Fly    95 TSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGV 159
            .|:|:|||:......:..|:.||..|:|:...|.|.|.|||..:|.::|||...|.::|:...||
Zfish   214 ISYFAKWWDSIDGQKQDAVRRLVENGQLEVATGGWVMPDEANAHYFAMIDQLVEGHQWLERNLGV 278

  Fly   160 CGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDAS-ESLSQVK 223
              :|:.||.:|||||:..||.:....|.......|:.::.|....:...||..|..: :..|...
Zfish   279 --KPKTGWAVDPFGHTATQAYLLKLAGLSNMLIQRVHYSVKKHFSSQKTLEFFWRQNWDQDSSTD 341

  Fly   224 LFTGLLYTFYWDTPGFCFDVH-CSDDP---------------------IIDSDSYDNNVKSRVDD 266
            :...::..:.:|.|      | |..||                     |......||||:.|...
Zfish   342 ILCHMMPFYSYDVP------HTCGPDPKICCQFDFKRLPGGRISCPWRIPPQAITDNNVQERAQT 400

  Fly   267 FIAYAAQVAEKFRTNHIMIPMGGDFQYEDA---EVNYKNMDKLIKYVNERQSSGSKYNIIYSTPT 328
            .:....:.::.|||..::.|:|.||:|.:|   :..::|..||..|:|.......|..  :.|.:
Zfish   401 LLDQYRKKSKLFRTKVLLAPLGDDFRYTEAVEWDQQFENYQKLFDYMNSHPELHVKAQ--FGTIS 463

  Fly   329 CYLNSVHKSV-----------QSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQV 382
            .|..::.||.           .:.|..:.|||.|....:.:|:||:||||..||.:|.....|:.
Zfish   464 DYFQALRKSTGMDPVGMNVGHLALPVVSGDFFTYADRDDHYWSGYFTSRPFYKRMDRMLESYLRA 528

  Fly   383 AKQLSA--FAELSSTQQKED---------LEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDA 436
            |:.|.:  .|.:....|..|         |...|..:|:.||||||.||.|..|..||...|:.:
Zfish   529 AEVLYSLTLANIQKYGQPSDYPAGENYKLLTEARRNLGLFQHHDAIAGTGKDWVVVDYGTRLFHS 593

  Fly   437 IVGGVKTAGDALRKLT--------NLPNGEFESCLQLNISECAFTKDGADNV-----VVTLYNAL 488
            |:...:....:...|.        |.|:..|.....:..|:.|..:.....|     ::.:.|.|
Zfish   594 ILNVKRVIVSSAHWLVLKDKQTYHNDPSKAFLQMDDVQQSQDALPRKNVLEVHGKPRLLVVSNPL 658

  Fly   489 AHTTKQYVRVPVKNENYQVTDEKGRVVASEIVPV-------PAEVLALEFRDSDTQHELVFKASV 546
            .......|.|.|...|.:|....|:||.:::..|       .|:|..|.|    ..|......||
Zfish   659 EQARTSMVTVYVNTPNVRVVSALGQVVRAQVSAVWKDASHATADVFQLSF----VAHAAPLGLSV 719

  Fly   547 DKIANYYIKKVDSKE---SSNGVRVISQPKAN--AETYDDE--ETIVQTSLIKLVLDNKTGLLKR 604
            .::......:.|:.:   ...| |.:|..|..  .:.|.|:  ..:::...::|.:...||||::
Zfish   720 YQLIEVMEPRTDASKYMFLQEG-RQLSDSKLEHFRQFYQDDGAPVVIENPHLRLSISGATGLLEK 783

  Fly   605 VEMNGVSENIEQS------YGLYRTYD-SGAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQR 662
            : |....|:..|.      ||...:.| ||||:|....:.............|..|.|..||...
Zfish   784 M-MLKEDESEHQMKVEFVWYGTTSSKDKSGAYLFLPDKEATIYSPSQPPVIRVTKGTLFSEVTTT 847

  Fly   663 FSEYISQVIRI----SEDKPYVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELI 723
            |: :|:..:|:    ..:...||   :...:.:..|...|:....:|::.|...|:||.||.::.
Zfish   848 FA-HITHTLRLYNTQGVEGQSVE---ICNTVDIRGETNREIAMRITSDLNSKDRFFTDLNGYQVQ 908

  Fly   724 RREKDKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRRL 788
            .|:         .:|..|...|:||:||.:.||||:.||::|..::.|..|:|.||:|:::.|||
Zfish   909 PRK---------TMAKLPLQANFYPMTSMLYLQDSSARLSLLTAQSLGAASLKSGQLEVIMDRRL 964

  Fly   789 VRDDGYGVGEALNEEK------------------------YGQPLIARGKVFLILNAADESTSAE 829
            .:||..|:|:.:.:.|                        |..|.|.....::.||....|.:..
Zfish   965 NQDDNRGLGQGVLDNKITANSFRLLLEKRISVEENEATAPYSYPSILSHMSYMYLNHPLISMAVS 1029

  Fly   830 REAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFDDFPKSVHLLTLEPFNDDEILLRVENFKDHIEG 894
            :..|....:|    :|             |....||..:||:.|......|            ||
Zfish  1030 QHLEAPSVVP----YS-------------PLKASFPCDMHLVNLRAIQSKE------------EG 1065

  Fly   895 KVVSFNI-----RPIFDYLNGVEIRETTL---------DGNLPLSDMKQFKFHAEGSGIRGSEPE 945
            ...|...     |..||.  |...|.|.|         |....|:|:|          ::...|.
Zfish  1066 GAASEQAALILHRKGFDC--GFSNRNTGLLCTSTRGKIDLEKLLTDLK----------VKSITPV 1118

  Fly   946 YYTSSHKPLSANQTQDAAEFAVTLYPMQIRTF 977
            ..:..|...|.::.|:     ::|..|:|||:
Zfish  1119 SLSLMHTLSSESRPQE-----ISLKAMEIRTY 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	88/299 (29%)
		Alpha-mann_mid	358..433	CDD:286360	31/85 (36%)
		Glyco_hydro_38C	481..977	CDD:285047	127/558 (23%)
man2a1	NP_001103497.2	PLN02701	127..1149	CDD:178304	268/1072 (25%)
		GH38N_Man2A1	163..509	CDD:212131	101/363 (28%)
		Alpha-mann_mid	504..590	CDD:214875	31/85 (36%)
		Glyco_hydro_38C	763..1145	CDD:285047	102/441 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910