Protein Alignment LManV and MAN2B1

DIOPT Version :10

• Sequence 1: NP_609252.1
• Gene: LManV / 34205
• FlyBaseID: FBgn0032068
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_001427499.1
• Gene: MAN2B1 / 4125
• HGNCID: 6826
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 1024
• Identity: 411/1024 - (40%)
• Similarity: 583/1024 - (56%)
• Gaps: 109/1024 - (10%)

  Fly     8 LCVAFLALQAKSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQ 72
            ||...|.|.|..|:| .|||:|...:.||:|:||:||:|||||||||||||:||.:|:|||||||
Human    35 LCFFLLLLAAAGARA-GGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQ 98

  Fly    73 YIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAV 137
            ||:|:|||.|:.:|.||||.||.:|||:||::|:...:.||:.||.:|||:|.||.|.||||||.
Human    99 YILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAAT 163

  Fly   138 NYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGR 202
            :|.:::||.|:||:||:||||..|||||.|.||||||||||||::|||||||.||.|:|:.||..
Human   164 HYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWV 228

  Fly   203 RMNDLALEMIWDASESLS--QVKLFTGLLYTFYWDTPGFCFDVHCSDDPII-DSDSYDNNVKSRV 264
            ||..|.:|.:|.||.||.  ...||||:|...|......|:||.|.|.|:: |..|.:.|.|..|
Human   229 RMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELV 293

  Fly   265 DDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVN-ERQSSGSKYNIIYSTPT 328
            |.|:..|......:||||.::.||.|||||:|.:.:||:||||:.|| ::|:.||..:::||||.
Human   294 DYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPA 358

  Fly   329 CYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFAELS 393
            |||..::|:..::..|..|||||....:.|||||::|||..||:||...:.|||..||.|...|:
Human   359 CYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLA 423

  Fly   394 ST---QQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAG---------D 446
            :.   ....|...|.|.|.|:|||||::||.:|||::||.|.|         .||         :
Human   424 ANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQL---------AAGWGPCEVLLSN 479

  Fly   447 ALRKLTNLPNGEFESCLQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEK 511
            ||.:|....: .|..|.|||||.|..::..| ...|.:||.|.......||:||....:.|.|..
Human   480 ALARLRGFKD-HFTFCQQLNISICPLSQTAA-RFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPN 542

  Fly   512 GRVVASEIVPVPAEVLALEFRDSDTQ-H--ELVFKASVDKI--ANYYIKKVDS-KESSNGVRVIS 570
            ||.|.|::|..|:         ||:| |  ||:|.||:..:  :.|.:.:|.. |..:...:.|
Human   543 GRTVPSDVVIFPS---------SDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPI- 597

  Fly   571 QPKAN---AETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSEN----IEQSYGLYRT----- 623
             |:.:   |.|.::|.       |:...|..||||  :|:..:::.    :.|::..|..
Human   598 -PRRSWSPALTIENEH-------IRATFDPDTGLL--MEIMNMNQQLLLPVRQTFFWYNASIGDN 652

  Fly   624 ---YDSGAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWL 685
               ..||||:||...|....:.. ..:..:....||:||||.||.:.|||:|:...:.::|.||.
Human   653 ESDQASGAYIFRPNQQKPLPVSR-WAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWS 716

  Fly   686 VGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPIT 750
            ||||||.:.:|.||::.|.:.:.:.|.|||||||||::.|.:|.|..:... ..:|.:|||||:.
Human   717 VGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLN-QTEPVAGNYYPVN 780

  Fly   751 SRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKYGQPLIARGKV 815
            :||.:.|.|.:|.:|.||:|||:|::||.:|||:||||::|||.||.|.|.|.  |.....||:.
Human   781 TRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMEN--GSGAWVRGRH 843

  Fly   816 FLILNAADESTSAER-EAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFD----DFPKSVHLLTLEP 875
            .::|:.|..:.:..| .||:|...|..........:....|.....|.    |.|.|||||||..
Human   844 LVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLAS 908

  Fly   876 FNDDEILLRVENFKDHIEGK--------VVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKF 932
            :..:.:|||:|:  ....|:        .|:.|:|.:|.......::||||..|.......:.|
Human   909 WGPEMVLLRLEH--QFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLK- 970

  Fly   933 HAEGSGIRGSEPEYYTSSHKPLSANQTQ---DAAEFAVTLYPMQIRTFI 978
                          :|::..| :.:||.   |.|.  :||.||:||||:
Human   971 --------------WTTNTGP-TPHQTPYQLDPAN--ITLEPMEIRTFL 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_609252.1	GH38N_AMII_LAM_like	37..311	CDD:212121	155/276 (56%)
		PLN02701	39..873	CDD:178304	366/875 (42%)
MAN2B1	NP_001427499.1	None