DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and MAN2A2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001307906.1	Gene:	MAN2A2 / 4122	HGNCID:	6825	Length:	1175	Species:	Homo sapiens

Alignment Length:	1101	Identity:	282/1101 - (25%)
Similarity:	450/1101 - (40%)	Gaps:	236/1101 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 HETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVE 94
            |:..:..:.:.:|||||:|.||:||.|:||...        .|:|:::::|:|.::|.|||:..|
Human   159 HDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAE 215

  Fly    95 TSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGV 159
            .|||:|||:..:...||.|:.||..|:|:...|.|.|.|||..:|.::|||...|.::|:...|
Human   216 VSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLG- 279

  Fly   160 CGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDAS-ESLSQVK 223
             ..||.||.:||||:|.....:..:.........|:.:..|.......:||.:|..: :|.|...
Human   280 -ATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTD 343

  Fly   224 LFTGLLYTFYWDTPGFCFDVH-CSDDPIIDSDSYD--------NNVKSRVDDFIAYAAQVAEK-- 277
            :|..::..:.:|.|      | |..||.| ...:|        .|...:|.......|.|||:
Human   344 IFCHMMPFYSYDVP------HTCGPDPKI-CCQFDFKRLPGGRINCPWKVPPRAITEANVAERAA 401

  Fly   278 ------------FRTNHIMIPMGGDFQY---EDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTP 327
                        ||:|.:::|:|.||:|   ::.:..:.|..:|..:.|.|.:...:..  :.|.
Human   402 LLLDQYRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQ--FGTL 464

  Fly   328 TCYLNSVHKSV--------QSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAK 384
            :.|.::::|..        ..:|..:.|||.|....:.:|||||||||..|..:|.....|:.|:
Human   465 SDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAE 529

  Fly   385 QLSAFAE-------LSSTQQKEDLEYL---REIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVG 439
            .|.:.|.       |:......|...|   |..:|:.|||||||||.|:.|..||
Human   530 VLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDY---------- 584

  Fly   440 GVKTAGDALRKLTNL----------------------PNGEFESCLQLNISECAFTK------DG 476
            ||:    .||.|.||                      |...|.......:|..|..:      |.
Human   585 GVR----LLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDS 645

  Fly   477 ADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEI----------------VPVPAE 525
            :...|| |:|.|.......|.:.|.:...:|..|:|:.:|.:|                |.||..
Human   646 SPRFVV-LFNPLEQERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVR 709

  Fly   526 VLALEFRDSDTQHELVFKASVDKIANYYI--KKVD-SKESSNGVRVISQPKANAETYDDEETIVQ 587
            :.||.......|..|....::......|:  :::. |:..:..:|||..        ...:..:.
Human   710 LPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDS--------GTSDFALS 766

  Fly   588 TSLIKLVLDNKTGLLKRVEMNGVSENIEQS-------YGLYRTYD-SGAYVFRQYNQGDFVIQED 644
            ...:::.....|||||.:..  |.|..||.       ||...:.| ||||:|....:....:.::
Human   767 NRYMQVWFSGLTGLLKSIRR--VDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKE 829

  Fly   645 GVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWL--VGPIPVEEEFGTEVVTIFSSEI 707
            .....|.:|....|| ..:.|:|.|.:|: .:.|.||...|  ...:.:.:....|:.....::|
Human   830 PPVLRVTEGPFFSEV-VAYYEHIHQAVRL-YNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDI 892

  Fly   708 ASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILNDRAQGG 772
            .|.|:|:||.||.::..|...|:         .|...|:||:.....:||:.|||.:...:|.|.
Human   893 DSQGIFFTDLNGFQVQPRRYLKK---------LPLQANFYPMPVMAYIQDAQKRLTLHTAQALGV 948

  Fly   773 TSMKDGQIELMLHRRLVRDDGYGVGEALNEEK--------------------YGQPLIA--RGKV 815
            :|:||||:|::|.|||::||..|:|:.|.:.|                    :...|.|  ||.:
Human   949 SSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEPDFFSKLAAMFRGLI 1013

  Fly   816 FLILNAADESTSAEREAEKEFHLPLWKFFSKNTGS-TTAAAKSVP------------SF----DD 863
            |      ..|.|..||.:...........|..|.. ..|.|.::|            ||    ..
Human  1014 F------HSSRSGNREVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASS 1072

  Fly   864 FPKSVHLLTLEPFNDDE---------ILLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLD 919
            .|...|||.|.....:|         ::|..:.|...:|.|.:.||.              ||..
Human  1073 LPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNC--------------TTSQ 1123

  Fly   920 GNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIK 980
            |.:.|..:    ||  |..:...:|...|..:...|.:.:.|     |.|.||:|.||.::
Human  1124 GKVALGSL----FH--GLDVVFLQPTSLTLLYPLASPSNSTD-----VYLEPMEIATFRLR 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	89/300 (30%)
		Alpha-mann_mid	358..433	CDD:286360	33/84 (39%)
		Glyco_hydro_38C	481..977	CDD:285047	135/572 (24%)
MAN2A2	NP_001307906.1	PLN02701	136..1174	CDD:178304	282/1101 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810