DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and alpha-Man-IIa

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	253/921 - (27%)
Similarity:	420/921 - (45%)	Gaps:	157/921 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRF 90
            |.:.|:.|     :.:|||||:|.||::|.::||       || ..::|:...:..|..||:.:|
  Fly   139 YNAHHKLK-----VFVVPHSHNDPGWIQTFEEYY-------QH-DTKHILSNALRHLHDNPEMKF 190

  Fly    91 IQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDD 155
            |..|.|:|::::::..|..:..:|.:|..|:|:|:.|.|.|.|||..::::|:.|.|.|..:|..
  Fly   191 IWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQ 255

  Fly   156 TFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIW-DASESL 219
            ...|  .|...|.|||||||.....|..:.||......|..::.|........||.:| ...::.
  Fly   256 FMNV--TPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNK 318

  Fly   220 SQVKLFTGLLYTFYWDTPGFCFDVH-CSDDPII-------DSDSY--------------DNNVKS 262
            ....|||.::..:.:|.|      | |..||.:       ...|:              |.||.:
  Fly   319 GDTALFTHMMPFYSYDIP------HTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAA 377

  Fly   263 RVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYE---DAEVNYKNMDKLIKYVNERQSSGSKYNI-- 322
            |.|..:....:.||.:|||.::||:|.||:::   :.:|...|.::|.:::|    |.:.:|:
  Fly   378 RSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHIN----SQAHFNVQA 438

  Fly   323 IYSTPTCYLNSVHKSVQS----YPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVA 383
            .:.|...|.::||::.::    :|..:.|||.|...::::|:|||||||..||.:|...|.::.|
  Fly   439 QFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAA 503

  Fly   384 KQLSAFAELSSTQQ-KEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDA 447
            :.|||:.......: :|.||..|..:.:.||||.||||.|.||..||::.:.:|:.........:
  Fly   504 EMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQS 568

  Fly   448 LRKLTNLPNGEFESCLQLNISECAFTKD------------------GAD---NVVVTLYNALAHT 491
            :.:|...|     |....:.|...||.|                  |.|   :..|.::|.|.|.
  Fly   569 VYRLLTKP-----SIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHW 628

  Fly   492 TKQYVRVPVKNENYQVTDEKGRVVASEIVPV-----PAEVLALEFRDSDTQHELVFKASVDK--I 549
            .:|.|...|.:....|||.....|.:::.||     ......:..:.|.|::.::|||.|..  :
  Fly   629 REQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGL 693

  Fly   550 ANYYIKKVDSKE-----SSNGVRVISQPKANAETYDDEETIVQTSLIKLVLDN-------KTGLL 602
            |.|.:...|||.     :||.:...:........|.::........|.|.:.|       :.|||
  Fly   694 ATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLL 758

  Fly   603 KRVEMNGVSENIE-----QSYGLYRTYD-SGAYVFR--------QYNQGDFVIQEDGVEFTVYDG 653
            |.:::...|.::.     ..||:....| ||||:|.        :..|...::.:..:|.:|..|
  Fly   759 KSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVG 823

  Fly   654 ALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSN 718
             |...|||......:..||...|         :|.:.     .||:|....:.|.|..:||||.|
  Fly   824 -LPSVVHQTIMRGGAPEIRNLVD---------IGSLD-----NTEIVMRLETHIDSGDIFYTDLN 873

  Fly   719 GRELIRREK-DKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIEL 782
            |.:.|:|.: ||          .|...|||||.|.:.::|:|.||.:|..:..||:|:..|::|:
  Fly   874 GLQFIKRRRLDK----------LPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEI 928

  Fly   783 MLHRRLVRDDGYGVGEALNEEKYGQPLIARGKVFL----------ILNAADESTSAEREAEKEFH 837
            |..|||..||..|:|:.:.:.|   |::...::.|          .|:.|...|||..:|.:...
  Fly   929 MQDRRLASDDERGLGQGVLDNK---PVLHIYRLVLEKVNNCVRPSELHPAGYLTSAAHKASQSLL 990

  Fly   838 LPLWKF-FSKN 847
            .||.|| |::|
  Fly   991 DPLDKFIFAEN 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	85/299 (28%)
		Alpha-mann_mid	358..433	CDD:286360	33/75 (44%)
		Glyco_hydro_38C	481..977	CDD:285047	110/412 (27%)
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	100/363 (28%)
		Alpha-mann_mid	478..554	CDD:214875	33/75 (44%)
		Glyco_hydro_38C	744..1103	CDD:285047	81/286 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450141
Domainoid	1	1.000	50	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I462
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790