DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and Man2b1

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_006255335.1	Gene:	Man2b1 / 361378	RGDID:	3039	Length:	1021	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	409/1044 - (39%)
Similarity:	602/1044 - (57%)	Gaps:	127/1044 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGI-VLCVAF---LALQAKSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYG--- 61
            ||: ||.::|   |.|.|..||| .||::|..||..|:|:||:||:||||||||||||||||
  Rat    27 LGLPVLSISFLIWLLLAAPGAQA-AGYKTCPTTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGMDP 90

  Fly    62 H--------RNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVN 118
            |        .:::|||.||||:|:||..|:.:|.||||.||.:|||:||.:|:...:..|:.||.
  Rat    91 HLLTFMPIVMSDVQHASVQYILDSVIYSLLNDPTRRFIYVEMAFFSRWWKQQTNVTQDAVRNLVR 155

  Fly   119 EGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYA 183
            :|||:|:||.|.||||||.:|.:::||.|:||:||.||||..|.|||.|.||||||||||||::|
  Rat   156 QGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFA 220

  Fly   184 QMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLS--QVKLFTGLLYTFYWDTPGFCFDVHCS 246
            ||||||.|..|:|:.||..|...|.:|.:|.||.||.  ...||||:|...|......|:||.|:
  Rat   221 QMGFDGFFLGRIDYQDKFNRKRKLKMEELWRASASLKPPAADLFTGVLPNNYNPPKDLCWDVLCT 285

  Fly   247 DDPIIDS-DSYDNNVKSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYV 310
            |.|::|. .|.:.|....||.|:..|:...:.:||||.::.||.|||||:|.:.:|||||||:.|
  Rat   286 DPPVVDDPTSPEFNANKLVDYFLNLASSQKKYYRTNHTVMTMGSDFQYENANMWFKNMDKLIRLV 350

  Fly   311 NE-RQSSGSKYNIIYSTPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFER 374
            || :|::|||.:::||||:|||..::|:..::..|..|||||....:.|||||::|||..||:||
  Rat   351 NEQQQANGSKVHVLYSTPSCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYER 415

  Fly   375 DGNHILQVAKQLSAFAELSSTQQK------EDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRIL 433
            ...:.|||..||.|   |...:.|      .|...|.|.|.|:|||||:|||.:|:|.:||.:.|
  Rat   416 LSYNFLQVCNQLEA---LVGPEAKVGPYGSGDSAPLNEAMAVLQHHDAVTGTARQNVVNDYAKQL 477

  Fly   434 YDAIVGGVKTAG---------DALRKLTNLPNGEFESCLQLNISECAFTKDGADNVVVTLYNALA 489
                     .||         :||.:| :|....|..|.::|||.|..::. :::..|.:||.:.
  Rat   478 ---------AAGWGPCEVLVSNALARL-SLYKQNFSFCREINISICPASQT-SEHFRVIIYNPVG 531

  Fly   490 HTTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPAEVLALEFRDSDT-QHELVFKASVDKI--AN 551
            ......||:||....:.|.|...|.::|.:|.||:..       |.| |.||:|.|||..:  :.
  Rat   532 RKVDLMVRLPVSEGIFLVKDPNDRRISSNVVMVPSAY-------SKTYQWELLFPASVPALGFSI 589

  Fly   552 YYIKKVDSKESSNGVRVISQPKANAETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQ 616
            |.:.|: |..:.....:.::||.:    .....:::...|:...|:.||||:::      ||:||
  Rat   590 YSVNKM-SGHNHQAHNLTARPKKS----KSRVLVIENKYIRATFDSDTGLLRKI------ENLEQ 643

  Fly   617 SYGL-----YRTYD-----------SGAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSE 665
            :..|     :..|:           ||||:||..::....:.. ..:.|:....||:||||.||.
  Rat   644 NISLPVRQGFFWYNASAGDEESPQASGAYIFRPSHRKPLPVSH-WAQVTLVKTNLVQEVHQNFSA 707

  Fly   666 YISQVIRISEDKPYVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKR 730
            :.|||||:.|.:.::|.||.||||||::::|.||::.|::.:.:.|.|:|||||||:::|    |
  Rat   708 WCSQVIRLYEGQRHLELEWTVGPIPVKDDWGKEVISRFNTPMRTRGQFFTDSNGREILKR----R 768

  Fly   731 EDFTPELAV---QPTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDD 792
            :||.|...:   :|.:|||||:.:||.:.|.:.:|.:|.||:|||:|:.||.:|||:||||:.||
  Rat   769 DDFRPTWTLNQTEPVAGNYYPVNTRIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHRRLLVDD 833

  Fly   793 GYGVGEALNEEKYGQPLIARGKVFLILNAADESTSAER-EAEKEFHLPLWKFFSKNTGSTTAAAK 856
            ..||.|.|.|...|..:  ||:..:||::..::.:..| .||:|...|  :....:.||:...::
  Rat   834 ERGVAEPLLETDTGDKV--RGRHLVILSSVSDAAARHRLLAEQEVLAP--QVVLAHGGSSPYHSQ 894

  Fly   857 SVPSFD------DFPKSVHLLTLEPFNDDEILLRVEN---FKDHIEGKV---VSFNIRPIFDYLN 909
            : |...      :.|..||||||..:....:|||:|:   .|:.....:   |:.|::.:|....
  Rat   895 A-PKMQFSALRRELPPQVHLLTLARWGPKMLLLRLEHQFAVKEDSNRNLSSPVTLNLQNLFKTFT 958

  Fly   910 GVEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQI 974
            ...::||||..|.|||.:.:.|:..:...|....|    |...|.|           :||.||||
  Rat   959 INYLQETTLAANQPLSRVSRLKWMTDTGPISYPAP----SRLDPTS-----------ITLQPMQI 1008

  Fly   975 RTFI 978
            |||:
  Rat  1009 RTFL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	149/287 (52%)
		Alpha-mann_mid	358..433	CDD:286360	37/80 (46%)
		Glyco_hydro_38C	481..977	CDD:285047	170/530 (32%)
Man2b1	XP_006255335.1	GH38N_AMII_LAM_like	63..351	CDD:212121	149/287 (52%)
		Alpha-mann_mid	399..477	CDD:214875	37/80 (46%)
		Glyco_hydro_38C	617..1011	CDD:285047	142/424 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341786
Domainoid	1	1.000	85	1.000	Domainoid score	I7978
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I460
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm44691
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770