DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and Man2b2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001128443.2	Gene:	Man2b2 / 360955	RGDID:	1308840	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	1078	Identity:	282/1078 - (26%)
Similarity:	457/1078 - (42%)	Gaps:	239/1078 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 INIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKW 101
            |...:|||||.||||:.||.:....:..|        :..||:.||::...||||.||..||..|
  Rat    27 IRAFVVPHSHMDVGWVYTVQESMRAYAAN--------VYTTVVEELVRGRQRRFIAVEQEFFRLW 83

  Fly   102 WN-EQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRV 165
            |: ..||..:..|:.|::||||:|:.|...|:|||..:....|.|.|.|..||.:|||:  ||:.
  Rat    84 WDGVASEQQKQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQF 146

  Fly   166 GWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLS-QVKLFTGLL 229
            .|.:||||.|....:::|..||:....||:|::.|........|:.:|..|.||| |.:::|.::
  Rat   147 SWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVWHGSPSLSEQQEIYTHVM 211

  Fly   230 YTFYWDTP---------GFCFD-VHCSDDPIIDSDSYDN--------NVKSRVDDFIAYAAQVAE 276
            ..:.:.||         ||.:: |....:|..|. .|.|        |:....:..:|...|.|.
  Rat   212 DLYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDG-VYPNMSEPVTVDNIHLYAEALVANVKQRAA 275

  Fly   277 KFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLNSVHK----- 336
            .|||.|::.|.|.|.|:.:|.|.:.|||.|::|:|.| |:....::.|:|...|..::|.
  Rat   276 WFRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNR-SAQFGISVQYATLNDYFQALHDFNVTW 339

  Fly   337 SVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFAE---------L 392
            .::.:.    ||.||.|:....|||::|||.|.|...|..:.:|...:  |.|..         |
  Rat   340 DIRDHH----DFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGE--SMFTRYMWPHPRGTL 398

  Fly   393 SSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVK-TAGDALRKLTNLPN 456
            ..|...:.|:.||..:..:||||||||||...|.:.|...|...:.|..| .|..||.:    |.
  Rat   399 DPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMRGVHKLMASIALDR----PP 459

  Fly   457 GEFESCLQLNISECAFTKDGADNVVV----TLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVAS 517
            |                 .|.|...|    ::||.||......:.:.|...:..||||.||.|::
  Rat   460 G-----------------SGTDTRPVGYSASVYNPLAWKITTIITLTVAFPSVSVTDELGRPVSA 507

  Fly   518 EIVPVPAEVLALEFRDSDTQHELVFKASVDKIANYYIKKVDSKESSNGVRVISQPKANA------ 576
            :|.....:..|         ::|:...::..::..:.|...::....|.|.:..|:||.
  Rat   508 QIQNSTKDPSA---------YDLLILTTIPGLSYRHYKVRRTRGDQAGTRELVTPRANTLKFSRK 563

  Fly   577 ---ETYDDEETI--VQTSLIKLVLDNKTGLLKRVE--MNGVSENIEQSYGLYRTYD-------SG 627
               :|..:.:.:  |......|:.|..|.:|..::  .:..:.::.|.:..||...       |.
  Rat   564 LRNQTSQEGKLLVPVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMTQEFLEYRANGDVKQGPISD 628

  Fly   628 AYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRF------SEYISQV-IRISEDKP------- 678
            .|:|...:..:...:..|:|..|  |.|..:|.|.|      ..||..: .|::...|
  Rat   629 NYLFASNDTAEPSWEAVGMEMVV--GTLATDVRQYFYRNITDQGYIYSIHTRLAHVHPSLAGELL 691

  Fly   679 --YVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQ- 740
              .:|.::.|||:    :...|.:...||::.|..|.|:|:||.::.||         |..|.:
  Rat   692 CRRIEQQYQVGPL----DLNREAILRTSSDLNSQQVLYSDNNGYQMQRR---------PYKAFKS 743

  Fly   741 -PTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRR----LVRDDGYGVGEAL 800
             |...||||:.....::|...||.:|.:|..|.:|.::||:|:|||||    ||.|..|.:  .|
  Rat   744 NPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQVEVMLHRRLWNNLVWDLNYNL--TL 806

  Fly   801 NEEKYGQPLIARGKVFLILNAADESTSAE-------------------REAEKEFH--------- 837
            |:.....|::     :|:|.....:|:..                   .|.|...|
  Rat   807 NDTSVVHPVL-----WLLLGPKSTTTALRPRSGVALQHRPVVLLKELTDEEETAIHRPHHPWPVT 866

  Fly   838 -----------LPLWKFFSKNTGSTTAAAKSVPSFDDFPKSVHLLTLE-------PFNDDEILLR 884
                       ||.|: :|:|                  .:.||..|:       ..|...:|||
  Rat   867 LPPSLHLQVLSLPGWQ-YSRN------------------HAQHLKNLQRGHPEKPQVNLQRVLLR 912

  Fly   885 VENFKDHIEGKVVSFNIRP----IFDYLNG----VEIRETTLDGNLPLSDMKQFKFHAEGSGIRG 941
            :.:..:..|..|:|   ||    :...|.|    |.:.|.:|.|...:..::::.:..:...::|
  Rat   913 LHHLYEAGEDPVLS---RPATVDLKIALRGLGSVVAVEERSLTGTWDVQTLQRWHWRTKIGQLKG 974

  Fly   942 SEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFII 979
                      .|.|..::...:  .:|:||.:||||.|
  Rat   975 ----------HPTSPPRSPGGS--IITVYPKEIRTFFI 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	101/293 (34%)
		Alpha-mann_mid	358..433	CDD:286360	29/83 (35%)
		Glyco_hydro_38C	481..977	CDD:285047	127/595 (21%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	234/827 (28%)
Man2b2	NP_001128443.2	GH38N_AMII_Epman_like	27..352	CDD:212122	112/340 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020