DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and LManII

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	1083	Identity:	483/1083 - (44%)
Similarity:	671/1083 - (61%)	Gaps:	129/1083 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGIVLCVAFL-ALQAKSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQ 67
            ||.::..|.| ::|.|::|  |||:|||.||.||:|:|||.|:||||||||||||||||....||
  Fly    15 LGCLIHDADLRSIQPKASQ--CGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQ 77

  Fly    68 HAGVQYIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMN 132
            .||||||||:|:..|:::|::|||.||::||.|||.||...::..|||||.:|||:||.||||||
  Fly    78 KAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWWKEQKPKVQEAVKMLVEQGRLEFIGGAWSMN 142

  Fly   133 DEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDH 197
            |||..:||||||||:.||:.|:||||.||||||||||||||||||.||::|||||||.||.|:|:
  Fly   143 DEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDY 207

  Fly   198 NDKGRRMNDLALEMIWDASESL-SQVKLFTGLLYTFYWDTPGFCFDVHCSDDPIID-SDSYDNNV 260
            .||..|:.....||||..|.:| .:..||:|.||..|....|||||:.|:|.|||| ..|.||||
  Fly   208 QDKDERLMTKNAEMIWHGSANLGEEADLFSGALYNNYQAPDGFCFDILCNDAPIIDGKHSPDNNV 272

  Fly   261 KSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYS 325
            |.|:|.|:.:|...::.:|||:|::.|||||.|:.|:|.|||:||||:|.||||::||..|::||
  Fly   273 KERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNINLLYS 337

  Fly   326 TPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFA 390
            ||:|||.|:|.:..::|.|:.|||||.||.:::||||:|||||.|||||||||.|||.|||||.|
  Fly   338 TPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALA 402

  Fly   391 ELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDALRKLT--- 452
            .....:....|.::||.:|:||||||||||||:.|:.||.:.:..|......|..:||.:||
  Fly   403 PKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQLTVQS 467

  Fly   453 --NLPNG------EFESCLQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTD 509
              |:.:.      ||::|..|||:.|. ..:..|...:||||.||||..:|||:||...||::.|
  Fly   468 KDNVKDTSAKYVFEFKTCALLNITSCP-VSEANDRFALTLYNPLAHTVNEYVRIPVPYSNYRIID 531

  Fly   510 EKGRVVASEIVPVPAEVLALEFRDSDTQHELVFKA-SVDKIA--NYYIKKVDSKESSNGVRVISQ 571
            .||..:.|:.||:|..::.::.|:|..::|:||.| ::..:.  .||::|:||.|.:...:.:
  Fly   532 NKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATNIPALGYRTYYVEKLDSTEGNTRSKAL-- 594

  Fly   572 PKANAETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQSYGLYR----------TYDS 626
            ||..:..     |::..|.|:|..|. .|.|..|..:|::..:.|.:..|.          ...|
  Fly   595 PKRTSSV-----TVIGNSHIQLGFDT-NGFLSEVTADGLTRLVSQEFLFYEGAVGNNAEFLNRSS 653

  Fly   627 GAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPV 691
            |||:||. |:.......|.||..||.|.||.||||:|:::||||:|:.....|.||||||||||:
  Fly   654 GAYIFRP-NENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVGPIPI 717

  Fly   692 EEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQ 756
            ::..|.||:|.|:|:|||:|:|.|||||||:|:|:.:.|:.::.::. :..:|||||||::|.::
  Fly   718 DDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKIN-EAVAGNYYPITTKIDVE 781

  Fly   757 DSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKYGQPLIARGKVFLILNA 821
            |...|:|||.||||||:|:|||.:|||:||||::||.:||||||||.:||..||||||..|....
  Fly   782 DDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGK 846

  Fly   822 ADESTSA-----EREAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFDD--------FPKSVHLLTL 873
            :.:....     ||..:.|..||.|||||..  ...:|.:...:|.:        .||.||||||
  Fly   847 STDREGVSLKGIERLTQLEKLLPTWKFFSNM--EDYSADEWQTAFTNIFSGISLVLPKPVHLLTL 909

  Fly   874 EPFNDDEILLR----VENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKF-- 932
            ||::::::|:|    :||.:|....:.|.||::.:....:...|||||||||..|.:.::.:|
  Fly   910 EPWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAWLDESRRLQFAP 974

  Fly   933 --------------------HA-----------------------------------------EG 936
                                |.                                         ||
  Fly   975 DPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRIRRETETRQEKKDEG 1039

  Fly   937 SGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFII 979
            ...:.:|..|  :|.|..|:||     |:.:.|.||:|||||:
  Fly  1040 RSSKSTEGPY--NSFKSDSSNQ-----EYIIELSPMEIRTFIV 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	167/275 (61%)
		Alpha-mann_mid	358..433	CDD:286360	46/74 (62%)
		Glyco_hydro_38C	481..977	CDD:285047	210/588 (36%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	167/275 (61%)
		Alpha-mann_mid	370..445	CDD:214875	46/74 (62%)
		Glyco_hydro_38C	502..957	CDD:285047	186/466 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450128
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	12	11.750