DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and LManI

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	964	Identity:	586/964 - (60%)
Similarity:	734/964 - (76%)	Gaps:	35/964 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSK 100
            |||:||||||||||||||||||||||.:|.|||||||||:|||:.||:|:..||||||||.||:|
  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65

  Fly   101 WWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRV 165
            |::||:||::..||.||.:|||:|..|||||||||.|:||||:|||.:||::|.||||.||||.|
  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130

  Fly   166 GWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLSQVKLFTGLLY 230
            ||||||||||||.|||:|||.|:||||:|||:.||.:||.||.:||||.:||||....:|||:||
  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKNSNIFTGMLY 195

  Fly   231 TFYWDTPGFCFDVHCSDDPIIDSDSYDNNVKSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYED 295
            ..|...||||||::|.|.||||.:||||||.:||.:||.|...:::.:|:.|||:|||.||||||
  Fly   196 NHYSAPPGFCFDINCEDAPIIDGESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQYED 260

  Fly   296 AEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWT 360
            |.||:|||||||||||:|||:||:.|:.||||:|||..:|:..|::||||.|||||.||::|:||
  Fly   261 AAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSHSYWT 325

  Fly   361 GYYTSRPTQKRFERDGNHILQVAKQLSAFAELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHV 425
            ||:|||||||||.|||||..|..||||..|.||.||..|||:.|.:.||:||||||:||||||.|
  Fly   326 GYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAV 390

  Fly   426 SDDYDRILYDAIVGGVKTAGDALRKLTNLPNGEFESCLQLNISECAFTKDGADNVVVTLYNALAH 490
            :.||||:|:.||||...:|.||||.||||.:|||||||:||||.||||:|.|:||:|||.|.|||
  Fly   391 ASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVTLVNPLAH 455

  Fly   491 TTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPAEVLALEFRDSDTQHELVFKASVDKIANYYIK 555
            ::.||||||.|||||.|||||||.|.||:||||.:|||||.|.:||||||||:||||||||:.|
  Fly   456 SSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIANFLI- 519

  Fly   556 KVDSKESSNGVRVISQPKANAETY-------DDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSEN 613
                       ||:..||..||..       ..:|..|:|||:||..|..||.||.|:|||.:||
  Fly   520 -----------RVLPSPKNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFTEN 573

  Fly   614 IEQSYGLYRTY----------DSGAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYIS 668
            |:|::|:|:.|          .|||||||.|  ||..|..:.||.:.|:|..||||||..:|:||
  Fly   574 IQQTFGIYKGYRGNNGESKNRSSGAYVFRPY--GDIEIVNNKVELSFYNGTKVKEVHQHVNEWIS 636

  Fly   669 QVIRISEDKPYVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDF 733
            |||||.||...|||||||||||.:::.|.|::|.|||.|:|.|.|||||||||::.||:::||.|
  Fly   637 QVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHF 701

  Fly   734 TPELAVQPTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGE 798
            ||::: :..||||||:|.:|:|||..||:.:||||||||||:|||::||||||||:.||.:||||
  Fly   702 TPDMS-EAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGVGE 765

  Fly   799 ALNEEKYGQPLIARGKVFLILNAADESTSAEREAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFDD 863
            ||||.:||..||||||::|||:|.|...: :|..:.:.....||||||:.|..:.....:|.|..
  Fly   766 ALNETQYGTGLIARGKIYLILDAVDGKPN-QRLLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFG 829

  Fly   864 FPKSVHLLTLEPFNDDEILLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMK 928
            .|:||.||:|||::.|:||:|:|||  :.||.||||||.|:|:.|:|.:|.|||||||:.|.|:|
  Fly   830 IPESVELLSLEPYSKDQILIRLENF--NTEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVK 892

  Fly   929 QFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIKHE 982
            :|||..:|:|...|..|||.:.|.||:||.|.:|:.|.|||.|||||||||:.:
  Fly   893 RFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRTFIIQQK 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	187/273 (68%)
		Alpha-mann_mid	358..433	CDD:286360	51/74 (69%)
		Glyco_hydro_38C	481..977	CDD:285047	281/512 (55%)
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	187/273 (68%)
		Alpha-mann_mid	323..398	CDD:286360	51/74 (69%)
		Glyco_hydro_38C	536..941	CDD:285047	220/410 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450124
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	13	12.760